Validity of a multi-domain computerized cognitive assessment battery for patients with multiple sclerosis

Autor: Glen M. Doniger, Daniel Golan, Timothy Fratto, Robert L. Kane, Jared Srinivasan, Lori Fafard, Jeffrey Wilken, Myassar Zarif, Marijean Buhse, Ilir Topalli, Mark Gudesblatt, Barbara Bumstead

Publikováno v: Multiple Sclerosis and Related Disorders. 30:154-162

Background Computerized cognitive batteries may facilitate the integration of neuropsychological assessments into routine clinical care of patients with multiple sclerosis (PwMS). Objective To assess the construct and criterion validity of a computer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9711daac9a39c0aff07a74c2f9a5a817
https://doi.org/10.1016/j.msard.2019.01.051

The impact of subjective cognitive fatigue and depression on cognitive function in patients with multiple sclerosis

Autor: Glen M. Doniger, Lori Fafard, Daniel Golan, Mark Gudesblatt, Myassar Zarif, Marijean Buhse, Jeffrey Wilken, Karl Wissemann, Idit Lavi, Barbara Bumstead

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England). 24(2)

Background: The association between subjective cognitive fatigue and objective cognitive dysfunction in patients with multiple sclerosis (PwMS) has been studied, with conflicting results. Objective: To explore the impact of fatigue on cognitive funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca022ec0d3f1322deed824c4c26b452
https://pubmed.ncbi.nlm.nih.gov/28273778

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease

Autor: Neila Mendis, Sherali Esmail, Jenna Smith, Emily Christopher, Charles S. Davis, Elaine Sperin, Victor W. Sung, Fredy J. Revilla, Jane S. Paulsen, Thomas Brashers-Krug, Shirley Eberly, Paola Wall, Andrew P. Duker, Clare Gibbons, Emily Houston, Pierre N. Tariot, Eric Molho, Susan R. Criswell, Marie Saint-Hilaire, Ali Samii, Lori Fafard, Joohi Jimenez-Shahed, Monica Beland, Olivia C. Roman, Blair R. Leavitt, Wai Lun Alan Fung, Greg Suter, Jacquelyn Whaley, Andrew Feigin, Mary Jane Ong, Ramon L. Rodriguez, Samuel Frank, Ronda Clouse, Anna Hohler, Elise Kayson, Russell L. Margolis, Erin Neefus, Laura Graffitti, Andrew McGarry, Sharon Evans, Cynthia A. Wong, Frederick C. Nucifora, Shari Kinel, Joseph Jankovic, Daniel Schneider, Arthur Watts, Margaret Herzog, Cory Hackmyer, Denyse Turpin, David Shprecher, Joanne Wojcieszek, Patrick Hickey, David Oakes, Karen Blindauer, Constance Orme, Christina L. Vaughan, Karen E. Anderson, Carlos Singer, Stewart A. Factor, Mary Eglow, Rajeev Kumar, Kathrin La Faver, Brad A. Racett, Victoria Snively, Mark Gudesblatt, Tilak Mendis, Mary Edmondson, Christine Hunter, Rohit Dhall, Christine O'Neill, James T. Boyd, Christopher A. Beck, Sylvain Chouinard, Lina Qi, Jon Edicola, Lynn Wheeler, Sarah Janicki, Burton L. Scott, Amanda Miller, Hilary E. Wilson-Pérez, Claudia M. Testa, Raymond C. James, Jody Goldstein, Pinky Agarwal, Richard Dubinsky, Eric S. Farbman, Jane Kerr, David Stamler, Carolyn Gray, Kevin Klos, Daniel O. Claassen, Kyle Rizer, Alexis Carlson, Hope Heller, Amy Colcher, Scott R. Evans, Monica Quesada, Christina Reeves

Publikováno v: JAMA. 316:40

Importance Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity. Obje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb9776d67c95630906f9e10a5561de6
https://doi.org/10.1001/jama.2016.8655