Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lori E. Heath"'
Publikováno v:
Journal of Pediatric Hematology/Oncology. 40:499-503
We evaluated psychometric properties (validity, reliability, and responsiveness) of a modified Faces Pain Scale-Revised (FPS-R) in 257 patients with sickle cell anemia (SCA) 7 to below 18 years old in a randomized, multinational clinical study. The m
Autor:
Lori E. Heath, Carlton Dampier, E. Tsiri Agbenyega, Julie Kanter, Raffaella Colombatti, Joseph A. Jakubowski, Nancy Robitaille, Jack Knorr, Hoda Hassab, Patricia B. Brown, Carolyn Hoppe, Deepa Manwani, Suqin Yao
Publikováno v:
British Journal of Haematology. 184:1058-1061
Autor:
Nicoletta Masera, Carlton Dampier, Tsiri Agbenyega, Joseph A. Jakubowski, Chunmei Zhou, Lori E. Heath, Carolyn Hoppe, Samuel Adjei, Matthew M. Heeney, Mohamed M. Badr, Patricia B. Brown
Publikováno v:
Clinical Trials. 14:563-571
Background/Aims: Patients with sickle cell anemia can experience recurrent pain episodes, which affect quality of life. The reported prevalence of pain is higher in studies using patient diaries than in healthcare facility utilization data. Determini
Autor:
Raffaella Colombatti, Suqin Yao, Hoda Hassab, Miguel R. Abboud, Chunmei Zhou, Baba Inusa, Patricia B. Brown, Joseph A. Jakubowski, Lori E. Heath, Matthew M. Heeney, David C. Rees, Bernhards Ogutu, Carolyn Hoppe
Publikováno v:
Journal of Clinical Medicine
Volume 8
Issue 11
Journal of Clinical Medicine, Vol 8, Iss 11, p 2009 (2019)
Volume 8
Issue 11
Journal of Clinical Medicine, Vol 8, Iss 11, p 2009 (2019)
Background: DOVE (Determining Effects of Platelet Inhibition on Vaso-Occlusive Events) was a Phase 3, randomized, double-blind, placebo-controlled study conducted in children with sickle cell anemia at 51 sites in 13 countries across four continents.
Autor:
Neehar Gupta, Lori E. Heath, Shelley M. Mays, Carlton Dampier, Diane M. Turner-Bowker, Emuella Flood, April N. Naegeli
Publikováno v:
The Patient
Background Patient diaries and pain scales can capture the course and complications of pain managed at home in children. The Faces Pain Scale-Revised (FPS-R) is a validated scale showing reliability in children, but it has not been validated in child
Autor:
Sohail Rana, Kenneth J. Winters, Julie Kanter, Darell Heiselman, Joseph A. Jakubowski, Rupa Redding-Lallinger, Brian A. Moser, Charles T. Quinn, Matthew M. Heeney, Lori E. Heath, Lori Styles, Chunmei Zhou, David S. Small
Publikováno v:
Journal of Pediatric Hematology/Oncology. 37:1-9
This phase 2 study was designed to characterize the relationship among prasugrel dose, prasugrel's active metabolite (Pras-AM), and platelet inhibition while evaluating safety in children with sickle cell disease. It was open-label, multicenter, adap
Autor:
Carolyn Hoppe, Baba Inusa, Neehar Gupta, Julie Kanter, Chunmei Zhou, Lori E. Heath, Joseph A. Jakubowski, Brendan E. Smith, Patricia B. Brown, David C. Rees, Suqin Yao, Matthew M. Heeney, David S. Small
Publikováno v:
Thrombosis and haemostasis. 117(3)
SummaryPatients with sickle cell anaemia (SCA) have vaso-occlusive crises resulting from occlusive hypoxic-ischaemic injury. Prasugrel inhibits platelet activation and aggregation involved in SCA pathophysiology. Determining Effects of Platelet Inhib
Autor:
David C. Rees, Raffaella Colombatti, Miguel R. Abboud, Nancy Robitaille, Hoda Hassab, Catherine I. Segbefia, Chunmei Zhou, Julie Kanter, Tsiri Agbenyega, Patricia B. Brown, Dmitry Zamoryakhin, Videlis Nduba, Janet Oyieko, Bernhards Ogutu, Lori E. Heath, Joseph A. Jakubowski, Matthew M. Heeney, Baba Inusa, Carolyn Hoppe
Publikováno v:
Heeney, M M, Hoppe, C C, Abboud, M R, Inusa, B, Kanter, J, Ogutu, B, Brown, P B, Heath, L E, Jakubowski, J A, Zhou, C, Zamoryakhin, D, Agbenyega, T, Colombatti, R, Hassab, H M, Nduba, V N, Oyieko, J N, Robitaille, N & Segbefia, C I & Rees, D C 2016, ' A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events ', New England Journal of Medicine, vol. 374, no. 7, pp. 625-635 . https://doi.org/10.1056/NEJMoa1512021
BACKGROUNDSickle cell anemia is an inherited blood disorder that is characterized by painfulvaso-occlusive crises, for which there are few treatment options. Platelets mediate intercellular adhesion and thrombosis during vaso-occlusion in sickle cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bbb6aa9c565795e55cf15d73bc3734
http://hdl.handle.net/11577/3353240
http://hdl.handle.net/11577/3353240
Autor:
Patricia B. Brown, Carolyn Hoppe, Kenneth J. Winters, Matthew M. Heeney, Lori Styles, Chunmei Zhou, Joseph A. Jakubowski, David C. Rees, Lori E. Heath
Publikováno v:
Pediatric bloodcancer. 63(2)
Background Sickle cell disease (SCD) is an inherited blood disorder characterized by painful vaso-occlusive crises (VOC) with limited treatment options, particularly for children. Emerging knowledge of the pathophysiology of SCD suggests antiplatelet
Autor:
Lori E. Heath, Carolyn Hoppe, Bhatnagar Pallav, Wendra M. Foster, Joseph A. Jakubowski, Sreekumar G. Pillai
Publikováno v:
Blood. 130:962-962
Introduction: Sickle cell disease (SCD) is complex, with marked inter-individual variability in disease severity. The clinical heterogeneity of SCD is largely influenced by genetic factors, including several well-established modifiers of fetal hemogl