Výsledky vyhledávání - "Lori C. Gowen"

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

Autor: Jennifer A. Griffiths, Lori C. Gowen, Keith D. Anderson, Niels C. Adams, George D. Yancopoulos, Stephanie M. Zabski, Jeffrey Vercollone, David M. Valenzuela, Stanley J. Wiegand, Mark W. Sleeman, Joel C. Reinhardt, Susan D. Croll, Andrew J. Murphy, Richard Torres

Publikováno v: Pain. 130:267-278

Neuromedin U (NMU) has recently been reported to have a role in nociception and inflammation. To clarify the function of the two known NMU receptors, NMU receptor 1 (NMUR1) and NMU receptor 2 (NMUR2), during nociception and inflammation in vivo, we g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06061b906a8a0f8d353a7253c3053b0b
https://doi.org/10.1016/j.pain.2007.01.036

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VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature

Autor: Roger B. Davis, Lori C. Gowen, Hiroya Hashizume, Matthew L. Springer, Shaun O'Brien, Amy Haskell, Donald M. McDonald, Betty Y. Y. Tam, Barbara Sennino, Scott M. Norberg, Gavin Thurston, Calvin J. Kuo, Shuji Joho, Tomomi Kamba, Keith D. Anderson, Michael R. Mancuso

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 290:H560-H576

Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function. However, VEGF is a survival factor for many tumor vessels, and there are clues that some normal blood vessels may also depend on VEGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4656711117b64bf70addd01440abd64b
https://doi.org/10.1152/ajpheart.00133.2005

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Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

Autor: Jane D. Murray, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Aris N. Economides, Stanley J. Wiegand, Katherine E. Wortley, Macdonald Lynn, Keith D. Anderson, Lori C. Gowen, Mark W. Sleeman, William Poueymirou, Mary V. Simmons, Dianna Barber

Publikováno v: Proceedings of the National Academy of Sciences. 102:2496-2501

We identified a glycoprotein hormone β-subunit (OGH, also called GPB5) that, as a heterodimer with the α-subunit GPA2, serves as a second ligand for the thyroid-stimulating hormone receptor. Mice in which the OGH gene is deleted (OGH-/-) are indist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4293b216897787c8c5823dd33d2a41c1
https://doi.org/10.1073/pnas.0409849102

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

Autor: David J. Glass, George D. Yancopoulos, William O. Kline, Mark W. Sleeman, Karen Garcia, Katherine E. Wortley, Jennifer Kintner, Ka-Man V. Lai, Lori C. Gowen, Stanley J. Wiegand, Trevor Stitt

Publikováno v: Nature Medicine. 11:199-205

Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death. In the previous study, the targeting construct left the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b215efee772a1ee775ea09e36a25447e
https://doi.org/10.1038/nm1178

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Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass

Autor: Amy L. Mansolf, Hua Zhu Ke, Lori C. Gowen, Hollis A. Simmons, George T. Tkalcevic, John D. McNeish, Thomas A. Brown, Kristen L. Chidsey-Frink, D.T. Crawford, Hong Qi, Jeffrey L. Stock, Donna N. Petersen

Publikováno v: Journal of Biological Chemistry. 278:1998-2007

We have previously described osteoblast/osteocyte factor 45 (OF45), a novel bone-specific extracellular matrix protein, and demonstrated that its expression is tightly linked to mineralization and bone formation. In this report, we have cloned and ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa726514d701f741436f5d1085d19b0
https://doi.org/10.1074/jbc.m203250200

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BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

Autor: Andrew Xiao, Amy R. Mohn, John N. Snouwaert, Anne M. Latour, Beverly H. Koller, Lauren M. DiBiase, Lori C. Gowen

Publikováno v: Oncogene. 18:7900-7907

BRCA1 is a nuclear phosphoprotein that has been classified as a tumor suppressor based on the fact that women carrying a mutated copy of the BRCA1 gene are at increased risk of developing breast and ovarian cancer. The association of BRCA1 with RAD51

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309c4dc6b86b8051b02a335e493e9ee2
https://doi.org/10.1038/sj.onc.1203334

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BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

Autor: Anna V. Avrutskaya, Beverly H. Koller, Lori C. Gowen, Steven A. Leadon, Anne M. Latour

Publikováno v: Science. 281:1009-1012

The breast and ovarian cancer susceptibility geneBRCA1encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9b33151e4719b7462ca867480087ec3
https://doi.org/10.1126/science.281.5379.1009

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

Autor: K K Sulik, B L Johnson, Lori C. Gowen, Anne M. Latour, Beverly H. Koller

Publikováno v: Nature Genetics. 12:191-194

The breast and ovarian cancer susceptibility gene, BRCA1, has been cloned and shown to encode a zinc-finger protein of unknown function. Mutations in BRCA1 account for at least 80% of families with both breast and ovarian cancer, as well as some non-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef02066d8266d56f8461bad69b0ef0b
https://doi.org/10.1038/ng0296-191

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Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse

Autor: Jason G. Weinger, Katrina K. Hoyer, Joshua J. Troke, Michael A. Teitell, Christian Raphalides, Jun Xu, Mark W. Sleeman, Irwin J. Kurland, Mathilde Renard, W.N. Paul Lee, Mohammed F. Saad, Bhavapriya Vaitheesyaran, Lori C. Gowen

Publikováno v: Diabetes. 55(12)

Despite altered regulation of insulin signaling, Pten(+/-) heterodeficient standard diet-fed mice, approximately 4 months old, exhibit normal fasting glucose and insulin levels. We report here a stable isotope flux phenotyping study of this "silent"

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82091f6e91c253add559280f77210456
https://pubmed.ncbi.nlm.nih.gov/17130482

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