Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Lori A Coburn"'
Autor:
Jia Li, Alan J. Simmons, Caroline V. Hawkins, Sophie Chiron, Marisol A. Ramirez-Solano, Naila Tasneem, Harsimran Kaur, Yanwen Xu, Frank Revetta, Paige N. Vega, Shunxing Bao, Can Cui, Regina N. Tyree, Larry W. Raber, Anna N. Conner, Jennifer M. Pilat, Justin Jacobse, Kara M. McNamara, Margaret M. Allaman, Gabriella A. Raffa, Alain P. Gobert, Mohammad Asim, Jeremy A. Goettel, Yash A. Choksi, Dawn B. Beaulieu, Robin L. Dalal, Sara N. Horst, Baldeep S. Pabla, Yuankai Huo, Bennett A. Landman, Joseph T. Roland, Elizabeth A. Scoville, David A. Schwartz, M. Kay Washington, Yu Shyr, Keith T. Wilson, Lori A. Coburn, Ken S. Lau, Qi Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Crohn’s disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify a di
Externí odkaz:
https://doaj.org/article/0ba81d63e38741479e8c66302f19cf18
Autor:
Kshipra Singh, Nicole T Al-Greene, Thomas G Verriere, Lori A Coburn, Mohammad Asim, Daniel P Barry, Margaret M Allaman, Dana M Hardbower, Alberto G Delgado, M Blanca Piazuelo, Bruce A Vallance, Alain P Gobert, Keith T Wilson
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005984 (2016)
Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens. We assessed the role of SLC7A2 in murine infection with Citrobacter
Externí odkaz:
https://doaj.org/article/dde25832be474145b30f534c31096627
Autor:
Dawn M Wiese, Sara N Horst, Caroline T Brown, Margaret M Allaman, Mallary E Hodges, James C Slaughter, Jennifer P Druce, Dawn B Beaulieu, David A Schwartz, Keith T Wilson, Lori A Coburn
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156387 (2016)
Ulcerative colitis (UC) is associated with increased dietary intake of fat and n-6 polyunsaturated fatty acids (PUFA). Modification of fat metabolism may alter inflammation and disease severity. Our aim was to assess differences in dietary and serum
Externí odkaz:
https://doaj.org/article/3a55dbd4926142afa64672cf0a83947e
Autor:
Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33838- (2024)
Hypusine is an amino acid synthesized by the enzyme deoxyhypusine synthase (DHPS). It is critical for the activity of eukaryotic translation initiation factor 5A (EIF5A). We reported that hypusination i) in macrophages supports the innate response to
Externí odkaz:
https://doaj.org/article/02fd8b1c2fd24f64a472e36bac86f199
Autor:
Lori A Coburn, Sara N Horst, Rupesh Chaturvedi, Caroline T Brown, Margaret M Allaman, Brooks P Scull, Kshipra Singh, M Blanca Piazuelo, Maithili V Chitnavis, Mallary E Hodges, Michael J Rosen, Christopher S Williams, James C Slaughter, Dawn B Beaulieu, David A Schwartz, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82300 (2013)
Accurate and high-throughput technologies are needed for identification of new therapeutic targets and for optimizing therapy in inflammatory bowel disease. Our aim was to assess multi-analyte protein-based assays of cytokines/chemokines using Lumine
Externí odkaz:
https://doaj.org/article/d4d7f74ea15f44989f08172ba757ae3f
Autor:
Lori A Coburn, Xue Gong, Kshipra Singh, Mohammad Asim, Brooks P Scull, Margaret M Allaman, Christopher S Williams, Michael J Rosen, M Kay Washington, Daniel P Barry, M Blanca Piazuelo, Robert A Casero, Rupesh Chaturvedi, Zhongming Zhao, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33546 (2012)
Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC), results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies are needed. One candidate is the semi-essential amino acid,
Externí odkaz:
https://doaj.org/article/533feca6ab3b4bd2a33c8baf8209e8b6
Autor:
Daniel P Barry, Mohammad Asim, Brooks P Scull, M Blanca Piazuelo, Thibaut de Sablet, Nuruddeen D Lewis, Lori A Coburn, Kshipra Singh, Lesley G Ellies, Alain P Gobert, Rupesh Chaturvedi, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29046 (2011)
Once acquired, Helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. Our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants
Externí odkaz:
https://doaj.org/article/09ba87fccc7840d89038169ee39687b0
Autor:
Justin Jacobse, Zaryab Aziz, Lili Sun, Jasmine Chaparro, Jennifer M. Pilat, Aaron Kwag, Matthew Buendia, Mae Wimbiscus, Motomi Nasu, Tsuyoshi Saito, Shinji Mine, Hajime Orita, Frank Revetta, Sarah P. Short, M. Kay Washington, Girish Hiremath, Michael K. Gibson, Lori A. Coburn, Tatsuki Koyama, Jeremy A. Goettel, Christopher S. Williams, Yash A. Choksi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 961-983 (2023)
Background and Aims: Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown. Methods: Eo
Externí odkaz:
https://doaj.org/article/535c54c9fb8d4824bb0c1da6e4ad6d4b
Autor:
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Publikováno v:
Oncogene. 42:1685-1691
Autor:
Shunxing Bao, Can Cui, Jia Li, Yucheng Tang, Ho Hin Lee, Ruining Deng, Lucas W. Remedios, Xin Yu, Qi Yang, Sophie Chiron, Nathan H. Patterson, Ken S. Lau, Qi Liu, Joseph T. Roland, Lori A. Coburn, Keith T. Wilson, Bennett A. Landman, Yuankai Huo
Publikováno v:
Medical Imaging 2023: Digital and Computational Pathology.