Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Lori, Sussel"'
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 6, Pp 649-655 (2024)
Abstract The β‐cell relies predominantly on glucose utilization to generate adenosine triphosphate, which is crucial for both cell viability and insulin secretion. The β‐cell has evolved remarkable metabolic flexibility to productively respond
Externí odkaz:
https://doaj.org/article/0aeab2e82b2048ada4c369c416364dc8
Autor:
Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. Nakayasu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-c
Externí odkaz:
https://doaj.org/article/6b57b4f4064a4390ae8f0840effa40ac
Autor:
Nicole D. Moss, Kristen L. Wells, Alexandra Theis, Yong-Kyung Kim, Aliya F. Spigelman, Xiong Liu, Patrick E. MacDonald, Lori Sussel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly
Externí odkaz:
https://doaj.org/article/699bd74104664f538706facd9bf80e73
Autor:
Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101632- (2022)
Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT
Externí odkaz:
https://doaj.org/article/1c21859e313c4bbbb1ba43957ea7e539
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Diabetes is an epidemic with increasing incidence across the world. Most individuals who are afflicted by this disease have type 2 diabetes, but there are many who suffer from type 1, an autoimmune disorder. Both types of diabetes have complex geneti
Externí odkaz:
https://doaj.org/article/eab46d67dad4410db458dc19325f9ef2
Autor:
Melissa S. Putman, Andrew W. Norris, Rebecca L. Hull, Michael R. Rickels, Lori Sussel, Scott M. Blackman, Christine L. Chan, Katie Larson Ode, Tanicia Daley, Arlene A. Stecenko, Antoinette Moran, Meagan J. Helmick, Sharon Cray, Jessica A. Alvarez, Virginia A. Stallings, Katherine L. Tuggle, John P. Clancy, Thomas L. Eggerman, John F. Engelhardt, Andrea Kelly
Publikováno v:
Diabetes. 72:677-689
Cystic fibrosis (CF) is a recessive disorder arising from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is expressed in numerous tissues, with high expression in the airways, small and lar
Autor:
Nicole D. Moss, Lori Sussel
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Robust endocrine cell function, particularly β cell function, is required to maintain blood glucose homeostasis. Diabetes can result from the loss or dysfunction of β cells. Despite decades of clinical and basic research, the precise regulation of
Externí odkaz:
https://doaj.org/article/54abc3dba03445d5a46bb06673e85ca6
Autor:
Elliott P Brooks, Lori Sussel
Publikováno v:
Journal of Endocrinology.
Historic and emerging studies provide evidence for the deterioration of pancreatic α cell function and identity in diabetes mellitus. Increased access to human tissue and the availability of more sophisticated molecular technologies have revealed ke
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene tran
Externí odkaz:
https://doaj.org/article/968038a22f9f439b81294cdabbc2f58a
Autor:
Fiona M. Docherty, Lori Sussel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3306 (2021)
Both type 1 and type 2 diabetes are characterized by a progressive loss of beta cell mass that contributes to impaired glucose homeostasis. Although an optimal treatment option would be to simply replace the lost cells, it is now well established tha
Externí odkaz:
https://doaj.org/article/e1f4056081db47dbb702e1fe1fa2d229