Výsledky vyhledávání - "Lori, Clarke"

1110. AZD7442 (Tixagevimab/Cilgavimab) Demonstrates Potent In Vitro Activity Against SARS-CoV-2 Spike Variants Identified in Circulation and in Prophylaxis Clinical Studies

Autor: Kevin M Tuffy, Michael E Abram, Tiffany L Roe, Bahar Ahani, Tyler Brady, Nicolette Schuko, Lori Clarke, Carolina Caceres, Tara Kenny, Virginia Takahashi, Tianhui Zhang, David E Tabor, Gustavo H Kijak, Elizabeth J Kelly, Katie Streicher

Publikováno v: Open Forum Infectious Diseases. 9

Background AZD7442 is a combination of extended–half-life SARS-CoV-2–neutralizing monoclonal antibodies (tixagevimab/cilgavimab) that bind to distinct epitopes on the SARS-CoV-2 spike protein. In the PROVENT study, a single 300 mg intramuscular d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f00ad5ab5f006dfffc94566f1d35d046
https://doi.org/10.1093/ofid/ofac492.949

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Computational Predictors in Online Social Deliberations

Autor: Beverly Woolf, Thomas Murray, Xiaoxi Xu, Leon Osterweil, Lori Clarke, Leah Wing, Ethan Katsh

Publikováno v: Proceedings of the International AAAI Conference on Web and Social Media. 6:603-606

This research seeks to identify online participants’ disposition and skills. A prototype dashboard and annotation scheme were developed to support facilitators and several computational predictors were identified that show statistically significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ae7b7d4b00a8c8813cdbe085f930b58
https://doi.org/10.1609/icwsm.v6i1.14325

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Development of a Parallel Reaction Monitoring Mass Spectrometry Assay for the Detection of SARS-CoV-2 Spike Glycoprotein and Nucleoprotein

Autor: Kuishu Ren, Shao Huan Samuel Weng, Sonja Hess, Raffaello Cimbro, Mahboobe Ghaedi, William F Dall'Acqua, Yasuhiro Ikeda, Nicole Kallewaard-Lelay, Lori Clarke, Chelsea C. Boo, Lisa H. Cazares, Sarav Rajan, Patrick M. McTamney, Raghothama Chaerkady, Hsiang En Hsu

Publikováno v: Analytical Chemistry

There is an urgent need for robust and high-throughput methods for SARS-CoV-2 detection in suspected patient samples to facilitate disease management, surveillance, and control. Although nucleic acid detection methods such as reverse transcription po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14781bd8309245636196bf3d31956a37
https://doi.org/10.1021/acs.analchem.0c02288

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Rational design of chimeric antigen receptor T cells against glypican 3 decouples toxicity from therapeutic efficacy

Autor: Maria Letizia Giardino Torchia, Ryan Gilbreth, Ashley Merlino, Erin Sult, Noel Monks, Jon Chesebrough, Ravinder Tammali, Nina Chu, Jessica Tong, John Meekin, Kevin Schifferli, Kapil Vashisht, Karma DaCosta, Lori Clarke, Christina Gesse, Xiao-Tao Yao, Courtney Bridges, Gordon Moody

Publikováno v: Cytotherapy. 24(7)

Chimeric antigen receptor (CAR) T cell therapy has yielded impressive clinical results in hematological malignancies and is a promising approach for solid tumor treatment. However, toxicity, including cytokine-release syndrome (CRS) and neurotoxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242ed3ff5fe04555c688ee511cd68580
https://pubmed.ncbi.nlm.nih.gov/35570170

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Akademický článek

S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo.

Autor: Bo Chen, Allison L Miller, Marlon Rebelatto, Yambasu Brewah, Daniel C Rowe, Lori Clarke, Meggan Czapiga, Kim Rosenthal, Tomozumi Imamichi, Yan Chen, Chew-Shun Chang, Partha S Chowdhury, Brian Naiman, Yue Wang, De Yang, Alison A Humbles, Ronald Herbst, Gary P Sims

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0115828 (2015)

Release of endogenous damage associated molecular patterns (DAMPs), including members of the S100 family, are associated with infection, cellular stress, tissue damage and cancer. The extracellular functions of this family of calcium binding proteins

Externí odkaz: https://doaj.org/article/60f3d5336bb947d188644086d880d193

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Abstract 2837: Synthetic TGFb blockade preserves effector function and maintains stemness of GPC3 CAR-T against hepatocellular carcinoma

Autor: Nina J. Chu, Michael G. Overstreet, Ryan Gilbreth, Lori Clarke, Christina Gesse, Eric Tu, Gordon Moody, Maria Letizia Giardino Torchia

Publikováno v: Cancer Research. 82:2837-2837

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer-related death worldwide. Immune checkpoint inhibitors have been recently approved in the first-line setting, however only 20-30%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce51a115c10522a640b45b7af95bf1d1
https://doi.org/10.1158/1538-7445.am2022-2837

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Preoperative Evaluation of the Entire Hepatic Vasculature in Living Liver Donors with Use of Contrast-enhanced MR Angiography and True Fast Imaging with Steady-state Precession

Autor: Michael Abecassis, R. L. McCarthy, J. Paul Finn, Andrew Blei, Lori Clarke, F. Scott Pereles, James C. Carr, Albert A. Nemcek

Publikováno v: Journal of Vascular and Interventional Radiology. 14:441-449

PURPOSE To preoperatively assess the entire hepatic vasculature in living related liver donors with use of a combination of contrast material–enhanced magnetic resonance (MR) angiography and true fast imaging with steady-state precession (FISP). MA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fdd0f5d303257e37d54fe2b659a2dd
https://doi.org/10.1097/01.rvi.0000064853.87207.42

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