TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

Autor: Berrout, J., Kyriakopoulou, E., Moparthi, L., Hogea, A.S., Berrout, L., Ivan, C., Lorger, M., Boyle, J., Peers, C., Muench, S., Elies, Jacobo, Hu, X., Hurst, C., Hall, T., Umamaheswaran, S., Wesley, L., Gagea, M., Shires, M., Manfield, I., Knowles, M.A., Davies, S., Suhling, K., Gonzalez, Y.T., Carragher, N., Macleod, K., Abbott, N.J., Calin, G.A., Gamper, N., Zygmunt, P.M., Timsah, Z.

Yes
Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD) where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression th

Externí odkaz: http://hdl.handle.net/10454/12962

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Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking

Autor: Taggart, D, Andreou, T, Scott, KJ, Williams, J, Rippaus, N, Brownlie, RJ, Ilett, EJ, Salmond, RJ, Melcher, A, Lorger, M

Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor activity in melanoma patients. Despite high frequency of melanoma brain metastases (BrM) and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7d859d912b19aeb93f6cf71401d725bb

Activated tumor cell integrin alpha v beta 3 cooperates with platelets to promote extravasation and metastasis from the blood stream

Autor: Weber, MR, Zuka, M, Lorger, M, Tschan, M, Torbett, BE, Zijlstra, A, Quigley, JP, Staflin, K, Eliceiri, BP, Krueger, JS, Marchese, P, Ruggeri, ZM, Felding, BH

Publikováno v: Weber, MR; Zuka, M; Lorger, M; Tschan, M; Torbett, BE; Zijlstra, A; et al.(2016). Activated tumor cell integrin alpha v beta 3 cooperates with platelets to promote extravasation and metastasis from the blood stream. THROMBOSIS RESEARCH, 140, S27-S36. doi: 10.1016/S0049-3848(16)30095-0. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6q3277tf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::4ba62f172e47adc6f1d3d622cf101499
http://www.escholarship.org/uc/item/6q3277tf

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

Autor: Abraham, S, Scarcia, M, Bagshaw, R, McMahon, K, Grant, G, Harvey, T, Yeo, M, Esteves, FOG, Thygesen, HH, Jones, PF, Spiers, V, Hanby, AM, Selby, PJ, Lorger, M, Dear, TN, Pawson, T, Marshall, CJ, Mavria, G

Publikováno v: Abraham, S, Scarcia, M, Bagshaw, R D, McMahon, K, Grant, G, Harvey, T, Yeo, M, Esteves, F O G, Thygesen, H H, Jones, P F, Speirs, V, Hanby, A M, Selby, P J, Lorger, M, Dear, T N, Pawson, T, Marshall, C J & Mavria, G 2015, ' A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. ', Nature Communications, vol. 6, 7286 . https://doi.org/10.1038/ncomms8286

During angiogenesis, Rho-GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e5887d439b75c4b51f32ef900b66d270
https://www.research.manchester.ac.uk/portal/en/publications/a-raccdc42-exchange-factor-complex-promotes-formation-of-lateral-filopodia-and-blood-vessel-lumen-morphogenesis(76445d51-ddd6-4605-971a-2b2101e43b86).html