Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Loretta Y Y, Chan"'
Autor:
Hongyu Li, Joseph C. K. Leung, Wai Han Yiu, Loretta Y. Y. Chan, Bin Li, Sarah W. Y. Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C. W. Tang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-15 (2022)
Abstract Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction i
Externí odkaz:
https://doaj.org/article/82f9885eca8b4c88bf8be3fca5551bed
Autor:
Bin Li, Joseph C. K. Leung, Loretta Y. Y. Chan, Wai Han Yiu, Ye Li, Sarah W. Y. Lok, Wing Han Liu, Kam Wa Chan, Hung Fat Tse, Kar Neng Lai, Sydney C. W. Tang
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 898-910 (2019)
Abstract Recent advances in the understanding of lipid metabolism suggest a critical role of endoplasmic reticulum (ER) stress in obesity‐induced kidney injury. Hepatocyte growth factor (HGF) is a pleiotropic cytokine frequently featured in stem ce
Externí odkaz:
https://doaj.org/article/a453fdba754f45889e9cc16ac51176ae
Autor:
Wai Han Yiu, Kam Wa Chan, Loretta Y. Y. Chan, Joseph C. K. Leung, Kar Neng Lai, Sydney C. W. Tang
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase involved in signal transduction in a variety of immune responses. It has been demonstrated that Syk plays a pathogenic role in orchestrating inflammatory responses and cell proliferation
Externí odkaz:
https://doaj.org/article/a4a3de2399374b749e791af0560293a5
Autor:
Sarah W Y Lok, Wai Han Yiu, Yixin Zou, Rui Xue, Hongyu Li, Jingyuan Ma, Jiaoyi Chen, Loretta Y Y Chan, Kar Neng Lai, Sydney C W Tang
Publikováno v:
Nephrology Dialysis Transplantation.
Background Thromboembolic events are prevalent in chronic kidney disease (CKD) patients due to increased thrombin generation leading to a hypercoagulable state. We previously demonstrated that inhibition of protease-activated receptor-1 (PAR-1) by vo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e0d66187142cc9a912265febfa8299
https://doi.org/10.1093/ndt/gfad051
https://doi.org/10.1093/ndt/gfad051
Autor:
Wai Han Yiu, Dickson W L Wong, Loretta Y Y Chan, Joseph C K Leung, Kwok Wah Chan, Hui Yao Lan, Kar Neng Lai, Sydney C W Tang
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88894 (2014)
Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the kallikrein-kinin system (KKS) has been linked to cellular inflammatory p
Externí odkaz:
https://doaj.org/article/461f80e8003f413c9fc02858f4d40d16
Autor:
Hao Jia Wu, Wai Han Yiu, Rui Xi Li, Dickson W L Wong, Joseph C K Leung, Loretta Y Y Chan, Yuelin Zhang, Qizhou Lian, Miao Lin, Hung Fat Tse, Kar Neng Lai, Sydney C W Tang
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90883 (2014)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood. As renal prognosis in CKD is
Externí odkaz:
https://doaj.org/article/57419aea3cdf445aa9cabd84538a4876
Autor:
Joseph Leung, Wai Han Yiu, Ruixi Li, Ai Ing Lim, Loretta Y Y Chan, Kar Neng Lai, Sydney C.W. Tang
Publikováno v:
Immunology and cell biology. 92(5)
Protein overload activates proximal tubule epithelial cells (PTECs) to release chemokines. Bone morphogenetic protein-7 (BMP-7) reduces infiltrating cells and tissue damage in acute and chronic renal injuries. The present study examines the inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758c84397541894f46038d160abe2aad
https://pubmed.ncbi.nlm.nih.gov/24418819
https://pubmed.ncbi.nlm.nih.gov/24418819
Autor:
Sydney C W, Tang, Loretta Y Y, Chan, Joseph C K, Leung, Amy S, Cheng, Miao, Lin, Hui Y, Lan, Kar N, Lai
Publikováno v:
Nephrology (Carlton, Vic.). 16(4)
The authors recently showed that advanced glycation end-products (AGE) in the form of glycated albumin (GA) upregulated renal tubular expression of interleukin (IL)-8 and soluble intercellular adhesion molecule-1 (sICAM-1), but not other important cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb6ecdcf0a4c024993068ec8e488634c
https://pubmed.ncbi.nlm.nih.gov/21143336
https://pubmed.ncbi.nlm.nih.gov/21143336
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 23(1)
Deposition of polymeric IgA1 (pIgA) in kidney mesangium is the hallmark of IgA nephropathy (IgAN). Current consensus is that a fraction of IgA1 molecules in the circulation of IgAN patients exhibit aberrant structures or properties that may lead to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60caa5f2c67eaaee5fef34b5bf32d516
https://pubmed.ncbi.nlm.nih.gov/17898021
https://pubmed.ncbi.nlm.nih.gov/17898021