Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Loretta Lau"'
Autor:
Jinhan Xie, Paulette Barahona, Michelle Haber, Emily Mould, Andrew J. Gifford, Loretta Lau, Amit Kumar, Timothy W. Failes, Marie Wong-Erasmus, Dylan Grebert-Wade, Greg M. Arndt, M. Emmy M. Dolman, Dong-Anh Khuong-Quang, Chelsea Mayoh, Kanika Bhatia, Shu-Oi Chow, Alvin Kamili, Roxanne Cadiz, Richard B. Lock, Maria Tsoli, Vanessa Tyrrell, David S. Ziegler, Glenn M. Marshall, Penny Athanasatos
Publikováno v:
Cancer Cytopathology. 129:805-818
Background The development of high-throughput drug screening (HTS) using primary cultures provides a promising, clinically translatable approach to tailoring treatment strategies for patients with cancer. However, this has been challenging for solid
Autor:
Nadine Azzam, Nicole Melong, Lissandra Tuzi, Lisa Pinto, Jamie I. Fletcher, Alvin Kamili, Biljana Dumevska, Loretta Lau, Jennifer A. Chan, Donna L. Senger, Stephanie A. Grover, Michelle Haber, David Malkin, Jason N. Berman
Publikováno v:
Cancer Research. 83:4670-4670
There has been dramatic improvement in treatment outcomes for many pediatric cancers over the last three decades. However, for the 20% of young people with relapsed or refractory cancer, the prognosis remains grim. Canada’s PRecision Oncology For Y
Autor:
Loretta Lau, Janine Vetsch, David S. Ziegler, Brittany C. McGill, David Malkin, Meera Warby, Katherine M. Tucker, Emily Duve, Claire E. Wakefield
Publikováno v:
JCO precision oncology. 3
PURPOSE Children with high-risk cancers have low survival rates because current treatment options are limited. Precision medicine trials are designed to offer patients individualized treatment recommendations, potentially improving their clinical out
Autor:
Loretta Lau, Yuchen Zhang, Sandra Sampl, Robert Lu, Roger R. Reddel, Yuan-Yin Chen, Medina Korkut-Demirbaş, Jeremy D. Henson, Rebecca A. Dagg, Joyce H. Y. Lee, Nancy Martin La Rotta, Klaus Holzmann
Publikováno v:
Cancers
Volume 13
Issue 21
Cancers, Vol 13, Iss 5369, p 5369 (2021)
Volume 13
Issue 21
Cancers, Vol 13, Iss 5369, p 5369 (2021)
Simple Summary A clinical test for alternative-lengthening-of-telomeres (ALT) could assist with cancer diagnosis and monitoring of disease progression. ALT-targeted anticancer treatments are being developed; however, there is no appropriate companion
Autor:
Marie Wong, Neevika Manoharan, Paul G Ekert, Geoff McCowage, Loretta Lau, Pamela Ajuyah, Anna Mullins, Akanksha Senapati, David S. Ziegler, Helen Doyle, Michael Rodriguez
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical course of this disease is variable. A rad
Autor:
Dong-Anh, Khuong-Quang, Lauren M, Brown, Marie, Wong, Chelsea, Mayoh, Alexandra, Sexton-Oates, Amit, Kumar, Mark, Pinese, Sumanth, Nagabushan, Loretta, Lau, Louise E, Ludlow, Andrew J, Gifford, Michael, Rodriguez, Jayesh, Desai, Stephen B, Fox, Michelle, Haber, David S, Ziegler, Jordan R, Hansford, Glenn M, Marshall, Mark J, Cowley, Paul G, Ekert
Publikováno v:
Cold Spring Harbor Molecular Case Studies
The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase (NTRK) family kinases in tumors has become critically important because of the availability of effective, specific inhibitor drugs. Whole-genome sequenci
Autor:
Mustafa Syed, Emmy D.G. Fleuren, Chelsea Mayoh, Velimir Gayevskiy, Richard B. Lock, Toby Trahair, Emilie E. Wilkie, Mark Pinese, Heather Tapp, Michelle Haber, Amit Kumar, Inigo Martincorena, Jonathan Baber, Alexandra Sherstyuk, Dylan Grebert-Wade, Rachel Bowen-James, Tracey A. O'Brien, Frank Alvaro, Marie Wong, Andrew J. Gifford, Luciano Dalla-Pozza, David S. Ziegler, Paul Wood, Murray D. Norris, Glenn M. Marshall, Marie Gauthier, David Thomas, Peter Priestley, Mark J. Cowley, Paul G Ekert, Nicholas G. Gottardo, M. Emmy M. Dolman, Vanessa Tyrrell, Dong Anh Khuong-Quang, Geoffry B. McCowage, Andrew S. Moore, Katherine M. Tucker, Emily Mould, Paulette Barahona, Judy Kirk, Loretta Lau, Seong Lin Khaw, Federico Abascal, Meera Warby, Elodie Manouvrier, Patricia Sullivan, Noemi A. Bolanos, Patrick Strong, Jordan R. Hansford
Publikováno v:
Nature medicine. 26(11)
The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from hi
Autor:
Loretta Lau, Mark J. Cowley, Paul G Ekert, Michael Rodriguez, Chelsea Mayoh, Richard J. Cohn, Velimir Gayevskiy, Marie Wong, Andrew J. Gifford, Mark Pinese, Amit Kumar, Mark Reynolds, Michelle Haber, David S. Ziegler, Vanessa Tyrrell, Michael C. Cox, Glenn M. Marshall, Dong-Anh Khuong-Quang, Emily Mould, Maria Tsoli
Publikováno v:
British Journal of Cancer
Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK fusions have a critical role in tumourigenesis in 40% of infant HGG. Here we report the fir
Autor:
Erdahl Teber, Oliver Holmes, Nicholas K. Hayward, Katia Nones, Loretta Lau, Hilda A. Pickett, Jonathan W. Arthur, Nicola Waddell, Graham J. Mann, James S. Wilmott, Christine E. Napier, Michael Lee, Rebecca A. Dagg, Roger R. Reddel, Sean M. Grimmond, Joyce H. Y. Lee, Ann-Marie Patch, Richard A. Scolyer, Peter Johansson, John V. Pearson
Publikováno v:
Nucleic Acids Research
The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme telomerase, or the Alternative Lengthening of Telomeres (ALT) pathway. Thes
Autor:
Michelle Haber, Marie Wong, Loretta Lau, Rachael L. Terry, Chelsea Mayoh, Dong Anh Khuong-Quang, Joseph A. Trapani, Mark J. Cowley, Paul G Ekert, Marion K. Mateos, David S. Ziegler, Vanessa Tyrrell, Paul J Neeson
Publikováno v:
Cancer Research. 81:3044-3044
In adult cancer, immune signatures such as the T cell-inflamed gene expression profile (GEP) have been developed to predict which patients are likely to respond to immune checkpoint inhibitors (ICIs) beyond high tumor mutation burden (TMB) and PD-L1