Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Loretta Ames Mcquaid"'
Autor:
Nancy B. Stamm, David W. Russell, Blake Lee Neubauer, Stefan Andersson, Loretta Ames Mcquaid, James E. Audia, Richard E. Toomey, Kenneth Steven Hirsch, Pam Pennington, Charles David Jones
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5277-5281
Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT from testosterone is catalyzed by two distinct membrane-bound steroid 5 alpha-reductase [5 al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a570e8637e64d7335a7cfe17488d4c01
https://doi.org/10.1073/pnas.90.11.5277
https://doi.org/10.1073/pnas.90.11.5277
Autor:
Kerry G. Bemis, David Ernest Lawhorn, Kenneth R. Hirsch, James E. Audia, James H. Wikel, Nancy B. Stamm, Pamela A. Pennington, Loretta Ames Mcquaid, Charles David Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1157-1162
QSAR models have been developed with regression analysis that related a specific lipophilic feature of the substituent of the molecule with biological activity. A second important feature of the compounds, the energy of the HOMO, was revealed using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b562b900581da3f589c557f2b660dc48
https://doi.org/10.1016/s0960-894x(00)80306-6
https://doi.org/10.1016/s0960-894x(00)80306-6
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:81-84
A series of 3-substituted acetic and propanoic acid derivatives of 5,7-dichlorokynurenic acid were prepared and evaluated as antagonists of the glycine site on the NMDA receptor complex. They were found to possess reduced affinity for the glycine sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f74e6c47942936b0af57d8fc273ad2a0
https://doi.org/10.1016/s0960-894x(00)80096-7
https://doi.org/10.1016/s0960-894x(00)80096-7
Publikováno v:
ChemInform. 22
Addition de triethylphosphite au (S)-N-(tert-butoxycarbonyl)-3-amino-2-oxetanone (I). L'addition nucleophile de trimethylphosphite a I donne le (S)-methyl N-(tert-butoxycarbonyl)-2-amino-3-(desethylphosphono) propanoate. Confirmation de la purete ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343626a3dc033181e77a5f228c92d0d0
https://doi.org/10.1002/chin.199111247
https://doi.org/10.1002/chin.199111247
Autor:
Charles H. Mitch, Rebecca A. True, Paul L. Ornstein, David O. Calligaro, Kimberly K. South, Darryle D. Schoepp, Edward C. R. Smith, Patrick J. O'Malley, David Lodge, Loretta Ames Mcquaid
Publikováno v:
ChemInform. 24
As part of our program aimed at the development of potent excitatory amino acid antagonists, we synthesized and evaluated a series of substituted 1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-ones, 4, tetrazolo[1,5-a]quinoxalin-4(5H)-ones, 5, and pyrazolo[1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f6f762cb651e39d9ea09af9b7ce2344
https://doi.org/10.1002/chin.199301212
https://doi.org/10.1002/chin.199301212
Autor:
Ann M. McNulty, Vincent Patrick Rocco, Loretta Ames Mcquaid, Blake Lee Neubauer, Edward C. R. Smith, Robin L. Goode, James E. Audia
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68cfa9525faccef994c93ef11ac4542
https://doi.org/10.1002/chin.199821138
https://doi.org/10.1002/chin.199821138
Autor:
Charles H. Mitch, Kimberly K. South, Rebecca A. True, Edward C. R. Smith, Loretta Ames Mcquaid, David Lodge, Darryle D. Schoepp, Patrick J. O'Malley, David O. Calligaro, Paul L. Ornstein
Publikováno v:
Journal of Medicinal Chemistry. 35:3319-3324
As part of our program aimed at the development of potent excitatory amino acid antagonists, we synthesized and evaluated a series of substituted 1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-ones, 4, tetrazolo[1,5-a]quinoxalin-4(5H)-ones, 5, and pyrazolo[1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a027e61b16091627a63521f8851985
https://doi.org/10.1021/jm00096a002
https://doi.org/10.1021/jm00096a002
Autor:
Dennis McNamara, Edward C. R. Smith, David O. Calligaro, Patrick J. O'Malley, Raymond Dingledine, Loretta Ames Mcquaid
Publikováno v:
Neuroscience Letters. 120:17-20
Fourteen substituted derivatives of kynurenic acid were compared for their ability to block ionic currents evoked by N-methyl-D-aspartate (NMDA) plus glycine, or kainate, in voltage-clamped Xenopus oocytes injected with rat brain messenger RNA. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9cf0d34b3a9e8a4f05171935bc26f0
https://doi.org/10.1016/0304-3940(90)90157-5
https://doi.org/10.1016/0304-3940(90)90157-5
Autor:
David M. Lodge, David O. Calligaro, James H. Wikel, Edward C. R. Smith, Etienne Pralong, Loretta Ames Mcquaid, Patrick J. O'Malley
Publikováno v:
Journal of Medicinal Chemistry. 35:3423-3425
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4567ebffc3fd7d6a07c05cf688655c7
https://doi.org/10.1021/jm00096a019
https://doi.org/10.1021/jm00096a019
Publikováno v:
The Journal of Organic Chemistry. 55:4472-4474
Addition de triethylphosphite au (S)-N-(tert-butoxycarbonyl)-3-amino-2-oxetanone (I). L'addition nucleophile de trimethylphosphite a I donne le (S)-methyl N-(tert-butoxycarbonyl)-2-amino-3-(desethylphosphono) propanoate. Confirmation de la purete ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18942688f01e1a5d55adbf783265a3c
https://doi.org/10.1021/jo00301a052
https://doi.org/10.1021/jo00301a052