Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Loretta A. Cipkus Dubray"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2187-2192
Bioisosteric substitution of the cyanoguanidine group found in pinacidil ( 1 ) with a 3,4-diamino-1,2,5-thiadiazole-1-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326c96c613a3c51b350623e96a7d9390
https://doi.org/10.1016/0960-894x(96)00397-6
https://doi.org/10.1016/0960-894x(96)00397-6
Autor:
Bharat V. Kamdar, William Watt, Mark L. Wolfe, Vincent E. Groppi, Loretta A. Cipkus Dubray, Michael P. Smith, Robert C. Gadwood, Stephen A. Mizsak
Publikováno v:
Journal of Medicinal Chemistry. 36:1480-1487
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of A10 rat aorta cells. This hyperpolarization was blocked by pretreatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57f66c957fa23d8308e33d322ac38c8
https://doi.org/10.1021/jm00062a022
https://doi.org/10.1021/jm00062a022
Publikováno v:
ChemInform. 28
Bioisosteric substitution of the cyanoguanidine group found in pinacidil ( 1 ) with a 3,4-diamino-1,2,5-thiadiazole-1-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8257eceb868b7a78fb78be82aaeb79
https://doi.org/10.1002/chin.199703178
https://doi.org/10.1002/chin.199703178
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:903-912
Using a series of functional criteria, we wished to evaluate the K+ conductance mechanism and the cyclic GMP mechanism implicated in the actions of nicorandil (NIC) as a vasodilator. In rabbit isolated superior mesenteric artery, NIC exhibited two re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7471dff8f82a235b606aeecac5d4a9a8
https://doi.org/10.1097/00005344-199106000-00007
https://doi.org/10.1097/00005344-199106000-00007
Publikováno v:
Journal of pharmacological methods. 24(4)
This study describes a sensitive in vitro relaxation assay using isolated rabbit mesenteric artery to detect the activity of a vasodilator as a K(+)-channel activator. Thus, comparison of several known K(+)-channel activators was made with other vaso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d7efe8f51496fc67cf8b41235e7650
https://pubmed.ncbi.nlm.nih.gov/2292878
https://pubmed.ncbi.nlm.nih.gov/2292878