Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Loreto Martinez-Gonzalez"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractCell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for
Externí odkaz:
https://doaj.org/article/a9474a61b420473c8be3cc0a61492459
Autor:
Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106430- (2024)
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in
Externí odkaz:
https://doaj.org/article/b4e04e092b5c4a59a6337799371bb688
Autor:
Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase
Externí odkaz:
https://doaj.org/article/e4f7366995854e60ba83492f730a9c84
Autor:
M. Lourdes Sciú, Victor Sebastián-Pérez, Loreto Martinez-Gonzalez, Rocio Benitez, Daniel I. Perez, Concepción Pérez, Nuria E. Campillo, Ana Martinez, E. Laura Moyano
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 87-96 (2019)
Numerous studies have highlighted the implications of the glycogen synthase kinase 3 (GSK-3) in several processes associated with Alzheimer’s disease (AD). Therefore, GSK-3 has become a crucial therapeutic target for the treatment of this neurodege
Externí odkaz:
https://doaj.org/article/02eaf3ea1ac54fe49215488f90ef2ccd
Autor:
Francesca Massenzio, Aixa V. Morales, Luis Emiliano Peña-Altamira, Sabrina Petralla, Barbara Monti, Maria Laura Bolognesi, Loreto Martinez Gonzalez, Elisa Uliassi, Ana Martínez, Michele Rossi, Marinella Roberti
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
50 p.-5 fig.
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1c49e2423d5f4c16e430dbc7d165c5
https://pubmed.ncbi.nlm.nih.gov/30253086
https://pubmed.ncbi.nlm.nih.gov/30253086
Autor:
Andrea Canal-Martín, Javier Sastre, María José Sánchez-Barrena, Angeles Canales, Sara Baldominos, Naiara Pascual, Loreto Martínez-González, Dolores Molero, Mª Encarnación Fernández-Valle, Elena Sáez, Patricia Blanco-Gabella, Elena Gómez-Rubio, Sonsoles Martín-Santamaría, Almudena Sáiz, Alicia Mansilla, F. Javier Cañada, Jesús Jiménez-Barbero, Ana Martínez, Ruth Pérez-Fernández
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-
Externí odkaz:
https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa
Autor:
Elisa Rojas-Prats, Carlota Tosat-Bitrián, Loreto Martínez-González, Vanesa Nozal, Daniel I. Pérez, Ana Martínez
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 180 (2021)
A potent cell division cycle 7 (CDC7) kinase inhibitor, known as PHA-767491, has been described to reduce the transactive response DNA binding protein of 43 KDa (TDP-43) phosphorylation in vitro and in vivo, which is one of the main proteins found to
Externí odkaz:
https://doaj.org/article/9a84000b6bc44c8893415a7f0b02f67d