Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lorenzo de Lichtervelde"'
Autor:
Lorenzo de Lichtervelde, Sophie B. Sun, Vaughn V. Smider, Yong Zhang, Danling Wang, Feng Wang, Peter G. Schultz
Publikováno v:
Angewandte Chemie International Edition. 52:8295-8298
Most mammalian antibodies have complementarity determining region (CDR) loops of 8–16 residues, while some human antibodies have longer, protruding CDR loops that play a role in virus neutralization.[1] The bovine antibody repertoire features a sub
Autor:
Yong Zhang, Danling Wang, Lorenzo de Lichtervelde, Sophie B. Sun, Vaughn V. Smider, Peter G. Schultz, Feng Wang
Publikováno v:
Angewandte Chemie. 125:8453-8456
Autor:
Peter G. Schultz, V. Deshmukh, Jonathan G. Swoboda, Shaomei Wang, Weijun Shen, Bin Lu, Matthew S. Tremblay, Charles Y. Cho, Eric C. Peters, Jimmy Elliott, S.V. Girman, Lorenzo de Lichtervelde
Publikováno v:
ACS Chemical Biology. 8:1407-1411
Retinal pigment epithelial (RPE) cells form a monolayer adjacent to the retina and play a critical role in the visual light cycle. Degeneration of RPE cells results in retinal disorders such as age-related macular degeneration. Cell transplant strate
Autor:
Anthony E. Boitano, Lorenzo de Lichtervelde, Peter G. Schultz, Michael P. Cooke, Philipp Krastel, Frank Petersen, Ying Wang
Publikováno v:
ACS chemical biology. 8(5)
Hematopoietic stem cells (HSCs) are the progenitor cells that give rise to all blood cells. The ability to control HSC differentiation has the potential to improve the success of bone marrow transplants and the production of functional blood cells ex
Autor:
Michael P. Cooke, Lorenzo de Lichtervelde, Peter G. Schultz, Jennifer Snead, Anthony E. Boitano
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(35)
Molecules that control the lineage commitment of hematopoietic stem cells (HSCs) may allow the expansion of enriched progenitor populations for both research and therapeutic uses. In an effort to better understand and control the differentiation of H
Autor:
Peter G. Schultz, Corina E. Antal, Ying Wang, Philipp Krastel, Anthony E. Boitano, Frank Petersen, Alexandra C. Newton, Lorenzo de Lichtervelde, Michael P. Cooke
Publikováno v:
Chemistrybiology. 19(8)
Summary To identify small molecules that selectively control hematopoietic stem cell differentiation, we performed an unbiased screen using primary human CD34 + cells. We identified a plant-derived natural product, euphohelioscopin A, capable of sele
Autor:
Sander van den Heuvel, Murat Cokol, Kevin Drew, Muhammed A. Yildirim, Joram D. Mul, Zoltan Maliga, Haidong Wang, Irma Lemmens, Frederick P. Roth, Fabio Piano, Anne-Lore Schlaitz, Diederik van de Peut, Miyeko D. Mana, Kristin C. Gunsalus, Huey Ling Kao, Anne Sophie de Smet, Jan Tavernier, Changyu Fan, Na Li, Anthony A. Hyman, Lilia M. Iakoucheva, David E. Hill, Kahn Rhrissorrakrai, Tong Hao, David N. Drechsel, Mike Tipsword, Niels Klitgord, Lorenzo de Lichtervelde, Richard Bonneau, Matilde Galli, Marc Vidal, Daphne Koller, Mike Boxem, Stuart Milstein, Maxime Devos, Nicolas Simonis, A. Keith Dunker
Publikováno v:
Cell, 134 (3
Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored this modular organization of proteins. We develope