Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Autor: Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo, Cristina Alli, Giacomo Paonessa, Gianni Colotti, Steven Harper, Annarita Fiorillo, Andrea Ilari, Alberto Bresciani

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008339 (2020)

Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive

Externí odkaz: https://doaj.org/article/6fee285090df47ca90b7a67167e262d5

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Autor: Lorenzo Turcano, Esther Torrente, Antonino Missineo, Matteo Andreini, Marina Gramiccia, Trentina Di Muccio, Ilaria Genovese, Annarita Fiorillo, Steven Harper, Alberto Bresciani, Gianni Colotti, Andrea Ilari

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006969 (2018)

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/trypare

Externí odkaz: https://doaj.org/article/af5f06d4d9594ea4b914709906958f7d

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Autor: Stefania Oliveto, Piera Calamita, Renata Grifantini, Lorenzo Turcano, Stefano Biffo, Elisa Pesce, Massimo Degano, Claudia Minici, Delia Cirino, Sara Ricciardi, Annarita Miluzio, Nicola Manfrini, Alberto Bresciani

Publikováno v: Cells, Vol 9, Iss 1, p 172 (2020)
Cells
Volume 9
Issue 1

Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a52197086b8ed32216cb596ef2c01f
https://doi.org/10.3390/cells9010172

Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells

Autor: Lorenzo Turcano, Adriana Eramo, Stefania Rossi, Ruggero De Maria, Claudio Tabolacci, Roberto Nisini, Giovanni Sette, Simone Beninati, Martina Cordella, Francesco Facchiano, Sabrina Mariotti, Alessandro Lentini, Lucia Piredda

Publikováno v: European Journal of Pharmacology. 762:283-292

Aim of this study was to extend the knowledge on the antineoplastic effect of aloe-emodin (AE), a natural hydroxyanthraquinone compound, both in metastatic human melanoma cell lines and in primary stem-like cells (melanospheres). Treatment with AE ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d93fc055cefaef2fcbbf353a4b994c
https://doi.org/10.1016/j.ejphar.2015.05.057

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Autor: Ilaria Genovese, Antonino Missineo, Annarita Fiorillo, Lorenzo Turcano, Matteo Andreini, Marina Gramiccia, Gianni Colotti, Trentina Di Muccio, Andrea Ilari, Alberto Bresciani, Steven J. Harper, Esther Torrente

Publikováno v: 'PLoS Neglected Tropical Diseases ', vol: 12, pages: e0006969-1-e0006969-21 (2018)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006969 (2018)

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/trypare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da35b434ada996357128b355845a587f
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51119