Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lorenzo Soini"'
Autor:
Marta Westwood, Christian Ottmann, M.A. Redhead, Lorenzo Soini, Seppe Leysen, Jeremy Martin Davis
Publikováno v:
RSC Medicinal Chemistry, 12(9), 1555-1564. Royal Society of Chemistry
RSC Medicinal Chemistry
RSC Medicinal Chemistry
The stabilisation of protein–protein interactions (PPIs) through molecular glues is a novel and promising approach in drug discovery. In stark contrast to research in protein–protein inhibition the field of stabilisation remains underdeveloped wi
Publikováno v:
Acta Crystallographica Section F: Structural Biology Communications, 77, 254-261. Wiley
Acta Crystallographica. Section F, Structural Biology Communications
Acta Crystallographica. Section F, Structural Biology Communications
The structures of two peptide motifs of Schnurri-3 in complex with 14-3-3 are reported.
14-3-3 proteins regulate many intracellular processes and their ability to bind in subtly different fashions to their numerous partner proteins provides attr
14-3-3 proteins regulate many intracellular processes and their ability to bind in subtly different fashions to their numerous partner proteins provides attr
Publikováno v:
Current opinion in chemical biology. 69
Targeting protein–protein interactions (PPIs) has become a common approach to tackle various diseases whose pathobiology is driven by their mis-regulation in important signalling pathways. Modulating PPIs has tremendous untapped therapeutic potenti
Autor:
Tomas Obsil, Huda Y. Zoghbi, Lech-Gustav Milroy, Christian Ottmann, L. Brunsveld, Rebecca Jane Burnley, Carolyn J. Adamski, Jeremy Martin Davis, Rachel Davis, Elizabeth Rodriguez, Larissa Nitschke, Seppe Leysen, Lorenzo Soini, Tom Crabbe
Publikováno v:
Journal of Molecular Biology, 433(19):167174. Academic Press Inc.
Journal of Molecular Biology
Journal of Molecular Biology
Graphical abstract
Highlights • 14-3-3 was postulated to prevent cytoplasmic aggregation of Ataxin-1. • Experimental support for an anti-aggregation effect of 14-3-3 on Ataxin-1 is provided. • Structural studies suggest 14-3-3 reduces Atax
Highlights • 14-3-3 was postulated to prevent cytoplasmic aggregation of Ataxin-1. • Experimental support for an anti-aggregation effect of 14-3-3 on Ataxin-1 is provided. • Structural studies suggest 14-3-3 reduces Atax
Publikováno v:
Journal of Structural Biology, 212(3):107662. Academic Press Inc.
Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2020, 212, pp.107662-. ⟨10.1016/j.jsb.2020.107662⟩
Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2020, 212, pp.107662-. ⟨10.1016/j.jsb.2020.107662⟩
B-cell linker protein (BLNK) is an adaptor protein that orchestrates signalling downstream of B-cell receptors. It has been reported to undergo proteasomal degradation upon binding to 14-3-3 proteins. Here, we report the first biophysical and structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11ab1721082791300cece1132ed79f6
https://research.tue.nl/nl/publications/10b5f58a-95ad-4b63-bb93-7c639a31489b
https://research.tue.nl/nl/publications/10b5f58a-95ad-4b63-bb93-7c639a31489b