Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lorenzo Sempere"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Perivascular adipose tissue (PVAT) regulates vascular function due to its capacity to synthesize vasoactive products and its mechanical properties. PVATs most abundant cells are adipocytes, and their populations are maintained by the maturation of ad
Externí odkaz:
https://doaj.org/article/863de7cdede4469aa3fdfcf1802b6846
Autor:
Aixia Sun, MD, PhD, Hanaan Hayat, BS, Elizabeth Kenyon, MS, Tahnia Quadri, BS, Darius Amos, BS, Keenan Perkins, BS, Saumya Nigam, PhD, Deanna Tarleton, BS, Christiane L. Mallett, PhD, Cheri X. Deng, PhD, Zhen Qiu, PhD, Wen Li, PhD, Lorenzo Sempere, PhD, Jinda Fan, PhD, Aitor Aguirre, PhD, Ping Wang, MD, PhD
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1658 (2024)
Background. Transplantation of human-induced pluripotent stem cell (hiPSC)-derived islet organoids is a promising cell replacement therapy for type 1 diabetes (T1D). It is important to improve the efficacy of islet organoids transplantation by identi
Externí odkaz:
https://doaj.org/article/3f037444dfe7407295fe2c837d727b56
Autor:
N. Anna Savan, Paulo Vilar Saavedra, Alan Halim, Vilma Yuzbasiyan-Gurkan, Ping Wang, Byunghee Yoo, Matti Kiupel, Lorenzo Sempere, Zdravka Medarova, Anna Moore
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Ninety percent of deaths from cancer are caused by metastasis. miRNAs are critical players in biological processes such as proliferation, metastasis, apoptosis, and self-renewal. We and others have previously demonstrated that miRNA-10b promotes meta
Externí odkaz:
https://doaj.org/article/08e05b70878c452684172a1cc0482271
Autor:
Alan Halim, N. Anna Savan, Paulo Vilar Saavedra, Vilma Yuzbasiyan-Gurkan, Matti Kiupel, Lorenzo Sempere, Anna Moore
Publikováno v:
Cancer Research. 83:P3-08
Despite many advances in cancer treatment, metastatic disease is estimated to be responsible for 90% of all cancer-related deaths. Current treatments for metastatic disease target various aspects of carcinogenesis but not specifically the metastatic
Autor:
Neil Robertson, Lorenzo Sempere, Elizabeth Kenyon, Christiane Mallet, Kylie Smith, Jeremy Hix, Alan Halim, Jinda Fan, Anna Moore
Publikováno v:
Molecular Imaging and Biology. 25:401-412
Individual imaging modalities have certain advantages, but each suffers from drawbacks that other modalities may overcome. The goal of this study was to create a novel contrast agent suitable for various imaging modalities that after a single adminis
Autor:
Ethan Dmitrovsky, Konstantin H. Dragnev, Sarah J. Freemantle, Yongli Guo, James DiRenzo, Hua Li, Jonathan M. Kurie, Gregory J. Tsongalis, David Johnstone, William Nugent, Bean N. Anyang, Jan H. Beumer, Lorenzo Sempere, Fadzai Chinyengetere, Vincent Memoli, Cherie P. Erkmen, Fabrizio Galimberti, Tian Ma
PDF file - 59K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293233d2b9247ba7f22547e289c26ff4
https://doi.org/10.1158/1535-7163.22499758
https://doi.org/10.1158/1535-7163.22499758
Autor:
Ethan Dmitrovsky, Konstantin H. Dragnev, Sarah J. Freemantle, Yongli Guo, James DiRenzo, Hua Li, Jonathan M. Kurie, Gregory J. Tsongalis, David Johnstone, William Nugent, Bean N. Anyang, Jan H. Beumer, Lorenzo Sempere, Fadzai Chinyengetere, Vincent Memoli, Cherie P. Erkmen, Fabrizio Galimberti, Tian Ma
PDF file - 652K, Supplemental Fig. 1: The structure of vorinostat (SAHA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105a4f3d2ef3685b4cb5999e5e2e61e2
https://doi.org/10.1158/1535-7163.22499770
https://doi.org/10.1158/1535-7163.22499770
Autor:
Ethan Dmitrovsky, Konstantin H. Dragnev, Sarah J. Freemantle, Yongli Guo, James DiRenzo, Hua Li, Jonathan M. Kurie, Gregory J. Tsongalis, David Johnstone, William Nugent, Bean N. Anyang, Jan H. Beumer, Lorenzo Sempere, Fadzai Chinyengetere, Vincent Memoli, Cherie P. Erkmen, Fabrizio Galimberti, Tian Ma
PDF file - 3079K, Supplemental Fig. 3: Paired pre-treatment versus post-vorinostat treatment biopsies from a lung cancer probed for p21 immunohistochemical expression. These representative biopsies from case 7 revealed an increase in p21 levels in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fd67fc10c14250c1ed28aba3c001ed
https://doi.org/10.1158/1535-7163.22499761
https://doi.org/10.1158/1535-7163.22499761
Autor:
Ethan Dmitrovsky, Konstantin H. Dragnev, Sarah J. Freemantle, Yongli Guo, James DiRenzo, Hua Li, Jonathan M. Kurie, Gregory J. Tsongalis, David Johnstone, William Nugent, Bean N. Anyang, Jan H. Beumer, Lorenzo Sempere, Fadzai Chinyengetere, Vincent Memoli, Cherie P. Erkmen, Fabrizio Galimberti, Tian Ma
Histone deacetylase inhibitor (HDACi; vorinostat) responses were studied in murine and human lung cancer cell lines and genetically engineered mouse lung cancer models. Findings were compared with a window of opportunity trial in aerodigestive tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbef3689ed0ad10ea5eb76149024221a
https://doi.org/10.1158/1535-7163.c.6536251
https://doi.org/10.1158/1535-7163.c.6536251
Autor:
Ethan Dmitrovsky, Konstantin H. Dragnev, Sarah J. Freemantle, Yongli Guo, James DiRenzo, Hua Li, Jonathan M. Kurie, Gregory J. Tsongalis, David Johnstone, William Nugent, Bean N. Anyang, Jan H. Beumer, Lorenzo Sempere, Fadzai Chinyengetere, Vincent Memoli, Cherie P. Erkmen, Fabrizio Galimberti, Tian Ma
PDF file - 1690K, Supplemental Fig. 2: Pharmacodynamic effects of vorinostat in (A) murine ED-1 lung cancer cells and (B) human HOP62 lung cancer cells. Vorinostat dose-dependent effects were investigated by immunoblot analyses for Bcl-2 family membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c16ff8bb04d8af2faaa58f1c1e0b76
https://doi.org/10.1158/1535-7163.22499764.v1
https://doi.org/10.1158/1535-7163.22499764.v1