The Citrus flavanone naringenin prolongs the lifespan in C. elegans and slows signs of brain aging in mice

Autor: Eugenia Piragine, Martina De Felice, Lorenzo Germelli, Vanessa Brinkmann, Lorenzo Flori, Claudia Martini, Vincenzo Calderone, Natascia Ventura, Eleonora Da Pozzo, Lara Testai

Publikováno v: Experimental Gerontology, Vol 194, Iss , Pp 112495- (2024)

Aging is one of the main risk factors for neurodegenerative disorders, which represent a global burden on healthcare systems. Therefore, identifying new strategies to slow the progression of brain aging is a compelling challenge. In this article, we

Externí odkaz: https://doaj.org/article/2aafe5b68c084df8b5bb4c954508caf7

DE NOVO NEUROSTEROIDOGENESIS ENABLES CHOLESTEROL HOMEOSTASIS IN HUMAN MICROGLIA PRESERVING THEIR PROPER FUNCTIONALITY: CRUCIAL ROLE OF 18 KDA TRANSLOCATOR PROTEIN

Autor: Elisa Angeloni, Lorenzo Germelli, Laura Marchetti, Eleonora Da Pozzo, Claudia Martini, Maria Letizia Trincavelli, Barbara Costa

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S359- (2023)

Externí odkaz: https://doaj.org/article/d69b0472d2fe44719ba5d18a2e24340a

Carbonic anhydrase activation profile of indole-based derivatives

Autor: Elisabetta Barresi, Rahul Ravichandran, Lorenzo Germelli, Andrea Angeli, Emma Baglini, Silvia Salerno, Anna Maria Marini, Barbara Costa, Eleonora Da Pozzo, Claudia Martini, Federico Da Settimo, Claudiu Supuran, Sandro Cosconati, Sabrina Taliani

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)

Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a

Externí odkaz: https://doaj.org/article/61803acb569c43b59486f5dce895777a

Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis

Autor: Chiara Tremolanti, Chiara Cavallini, Laurence Meyer, Christian Klein, Eleonora Da Pozzo, Barbara Costa, Lorenzo Germelli, Sabrina Taliani, Christine Patte-Mensah, Ayikoé-Guy Mensah-Nyagan

Publikováno v: Molecular Neurobiology. 59:1744-1765

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells, immune-mediated attack of the myelin sheath, neuroinflammation, and/or axonal/neuronal dysfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5eca6ae35666a3b453e7ae57345b85
https://doi.org/10.1007/s12035-022-02737-2

Carbonic anhydrase activation profile of indole-based derivatives

Autor: Federico Da Settimo, Sandro Cosconati, Claudia Martini, Eleonora Da Pozzo, Claudiu T. Supuran, Andrea Angeli, Elisabetta Barresi, Barbara Costa, Lorenzo Germelli, Rahul Ravichandran, Emma Baglini, Silvia Salerno, Sabrina Taliani, Anna Maria Marini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ab3f3c620e14b64aa7da5388937e37
https://doaj.org/article/61803acb569c43b59486f5dce895777a