Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Lorenzo Gaetani"'
Autor:
Teresa Zelante, Giuseppe Paolicelli, Francesca Fallarino, Marco Gargaro, Gianluca Vascelli, Marco De Zuani, Jan Fric, Petra Laznickova, Marcela Hortova Kohoutkova, Antonio Macchiarulo, Daniela Dolciami, Giuseppe Pieraccini, Lorenzo Gaetani, Giulia Scalisi, Caterina Trevisan, Barbara Frossi, Carlo Pucillo, Antonella De Luca, Emilia Nunzi, Roberta Spaccapelo, Marilena Pariano, Monica Borghi, Francesca Boscaro, Riccardo Romoli, Andrea Mancini, Lucia Gentili, Giorgia Renga, Claudio Costantini, Matteo Puccetti, Stefano Giovagnoli, Maurizio Ricci, Martina Antonini, Paolo Calabresi, Paolo Puccetti, Massimiliano Di Filippo, Luigina Romani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the underlining mec
Externí odkaz:
https://doaj.org/article/ef3dd28764624aada7153b8839b12acc
Autor:
Harald Hegen, Klaus Berek, Paola Cavalla, Mikael Christiansen, Andreja Emeršič, Massimiliano Di Filippo, Lorenzo Gaetani, Michaela Hassler, Cyra Leurs, Dejan Milosavljevic, Vincent van Pesch, Thor Petersen, Stefan Presslauer, Igal Rosenstein, Uroš Rot, Christine Schnabl, Charlotte Teunissen, Domizia Vecchio, Marco Vercellino, Florian Deisenhammer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundKappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple s
Externí odkaz:
https://doaj.org/article/f2268023c7d1409780b691eaa832cee5
Autor:
Anna Lidia Wojdała, Giovanni Bellomo, Lorenzo Gaetani, Andrea Toja, Elena Chipi, Dandan Shan, Davide Chiasserini, Lucilla Parnetti
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106356- (2023)
CSF-to-plasma transition will open new avenues for molecular phenotyping of Alzheimer's disease (AD). Here we evaluated a panel of AD biomarkers in matched CSF and plasma samples across the AD continuum, from preclinical AD to dementia. The aims were
Externí odkaz:
https://doaj.org/article/5a8d4aa8cf5947eb97ea1bd0c814c472
Autor:
Silvia Paciotti, Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Elena Chipi, Sander R. Piersma, Thang V. Pham, Lorenzo Gaetani, Connie R. Jimenez, Lucilla Parnetti, Davide Chiasserini
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Alzheimer’s disease (AD) cerebrospinal fluid (CSF) core biomarkers (Aβ42/40 ratio, p-tau, and t-tau) provide high diagnostic accuracy, even at the earliest stage of disease. However, these markers do not fully reflect the compl
Externí odkaz:
https://doaj.org/article/8734a334353f401e8bf8593ff2eaad52
Autor:
Federico Paolini Paoletti, Lorenzo Gaetani, Giovanni Bellomo, Elena Chipi, Nicola Salvadori, Chiara Montanucci, Andrea Mancini, Marta Filidei, Pasquale Nigro, Simone Simoni, Nicola Tambasco, Massimiliano Di Filippo, Lucilla Parnetti
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Pathophysiological substrate(s) and progression of Parkinson’s disease (PD) with mild cognitive impairment (PD-MCI) are still matter of debate. Baseline cerebrospinal fluid (CSF) neurochemical profile and cognitive changes after 2 years we
Externí odkaz:
https://doaj.org/article/48e9b6549f95488188b812cdb725fb5f
Autor:
Lorenzo Gaetani, Giovanni Bellomo, Elena Di Sabatino, Silvia Sperandei, Andrea Mancini, Kaj Blennow, Henrik Zetterberg, Lucilla Parnetti, Massimiliano Di Filippo
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 139 (2023)
Early diagnosis of multiple sclerosis (MS) relies on clinical evaluation, magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) analysis. Reliable biomarkers are needed to differentiate MS from other neurological conditions and to define th
Externí odkaz:
https://doaj.org/article/8775af09e86245b9b9de88f06097113f
Autor:
Leonardo Biscetti, Gioacchino De Vanna, Elena Cresta, Ilenia Corbelli, Lorenzo Gaetani, Letizia Cupini, Paolo Calabresi, Paola Sarchielli
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-28 (2021)
Abstract Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly,
Externí odkaz:
https://doaj.org/article/1d77937e284841f9ae9fee0d62d0af8d
Publikováno v:
The Lancet Regional Health. Europe, Vol 22, Iss , Pp 100512- (2022)
Externí odkaz:
https://doaj.org/article/557fe11333fc4d919d6cb670e660e383
Autor:
Lorenzo Gaetani, Nicola Salvadori, Elena Chipi, Lucia Gentili, Angela Borrelli, Lucilla Parnetti, Massimiliano Di Filippo
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 1, Pp 36-42 (2021)
Cognitive impairment is a common clinical manifestation of multiple sclerosis, but its pathophysiology is not completely understood. White and grey matter injury together with synaptic dysfunction do play a role. The measurement of biomarkers in the
Externí odkaz:
https://doaj.org/article/40bf8f6ab4004f8190d15cc00bc68714
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The identification of neurological diseases in their presymptomatic phase will be a fundamental aim in the coming years. This step is necessary both to optimize early diagnostics and to verify the effectiveness of experimental disease modifying drugs
Externí odkaz:
https://doaj.org/article/4653b46123af4ee8a9bd1c7ee2b4d043