High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

Autor: Donjete Simnica, Simon Schliffke, Christoph Schultheiß, Nicola Bonzanni, Lorenzo F. Fanchi, Nuray Akyüz, Barbara Gösch, Christian Casar, Benjamin Thiele, Janina Schlüter, Ansgar W. Lohse, Mascha Binder

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune system. Using next-generation immunosequencing we profiled 59 T and B cell repertoires (TRB and I

Externí odkaz: https://doaj.org/article/643ce934f7af4395b31790349e5bfbdb

Data from Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells

Autor: Vincenzo Cerundolo, Ton N. Schumacher, Ahmed A. Ahmed, Jose A. Enríquez, Jan Rehwinkel, Siamon Gordon, Zhiyuan Hu, Mara Artibani, Lorenzo F. Fanchi, Vivian Wing Chong Lau, Melissa Bedard, Silvia Galiani, Ji-Li Chen, Ana Victoria Lechuga-Vieco, Margarida Rei, Uzi Gileadi, Gennaro Prota

Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b8d2702174140e28a0bcef05e5da4d
https://doi.org/10.1158/2326-6066.c.6550353

Next‐Generation Immunosequencing Reveals Pathological T‐Cell Architecture in Autoimmune Hepatitis

Autor: Christina Weiler-Normann, Lorenzo F. Fanchi, Christoph Schultheiß, Nicola Bonzanni, Donjete Simnica, Nils H. Wildner, Julian Schulze zur Wiesch, Mascha Binder, Ansgar W. Lohse, Anna Oberle, Edith Willscher

Publikováno v: Hepatology. 73:1436-1448

Background and aims Autoimmune hepatitis (AIH) is a chronic liver disease that regularly relapses when immunosuppression is tapered. It is thought to be driven by T-cells, whereas the etiologic impact of an apparently deregulated B lineage system, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c6d25cc8ec45c80a990b80a77b4b3c
https://doi.org/10.1002/hep.31473

Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells

Autor: Melissa Bedard, Ji-Li Chen, Mara Artibani, Jan Rehwinkel, Silvia Galiani, Vivian W. C. Lau, Zhiyuan Hu, Lorenzo F. Fanchi, M Rei, Ahmed Ashour Ahmed, Ton N. Schumacher, Uzi Gileadi, Vincenzo Cerundolo, Ana Victoria Lechuga-Vieco, Siamon Gordon, Gennaro Prota, José Antonio Enríquez

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)

Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c304d7bc6eb9e45158d754b8320501
https://doi.org/10.1158/2326-6066.cir-19-0467

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Autor: Zhiqin Huang, Pramod K. Srivastava, Song Liu, Jason A. Greenbaum, Dirk Jäger, Jiaqian Wang, Ognjen Milicevic, Willem-Jan Krebber, Barbara Schrörs, Sean Michael Boyle, Michal Bassani-Sternberg, Ana M. Mijalkovic Lazic, Amit A. Lugade, Kristen K. Dang, Han Si, Alessandro Sette, Jeffrey P. Ward, Irsan Kooi, Michael F. Princiotta, Begonya Comin-Anduix, Thierry Schuepbach, Pia Kvistborg, Julia Kodysh, William Chour, Vladimir B. Kovacevic, Jan H. Kessler, Ariella Sasson, Antoni Ribas, Brian Stevenson, Sriram Sridhar, Prateek Tanden, Robert D. Schreiber, Jason Perera, Kathleen C. F. Sheehan, Hira Rizvi, Sachet A. Shukla, Baikang Pei, Han Chang, Bo Li, Ion I. Mandoiu, Cristina Puig-Saus, Beatriz M. Carreno, Si Qiu, Jennifer M. Shelton, Patrick Jongeneel, Qiang Hu, Taha Merghoub, Matthew D. Hellmann, James P. Conway, Francisco Arcila, Ton N. Schumacher, Mathias Vormehr, Christopher A. Morehouse, Patrice Manning, Jonathon Blake, Pornpimol Charoentong, Angela Frentzen, Christopher A. Miller, Michael A. Kuziora, Bin Song, Lei Wei, Martin Löwer, Gabor Bartha, Justin Guinney, Niels Halama, Rolf Hilker, Yinong Sebastian, Veliborka Josipovic, Jason Harris, Geng Liu, Guilhem Richard, Arjun A. Rao, Nikola M. Skundric, Markus Mueller, Daniel K. Wells, Tatiana Shcheglova, Inka Zörnig, Weixuan Fu, John Sidney, Nadine Defranoux, Gabriela Steiner, Joseph D. Szustakowski, Arbel D. Tadmor, Maxim N. Artyomov, Jianmin Wang, George Coukos, Brandon W. Higgs, Milica R. Kojicic, Siranush Sarkizova, Daphne van Beek, Naibo Yang, Robert Ziman, Mignonette H. Macabali, Thomas Yu, Nicolas Guex, Nina Bhardwaj, Lorenzo F. Fanchi, Bjoern Peters, Christian Iseli, Song Wu, Maren Lang, Juliet Forman, Marit M. van Buuren, David Balli, Steven L. C. Ketelaars, Nir Hacohen, Ekaterina Esaulova, Maarten Slagter, Todd Creasy, Robert A. Petit, Yi-Hsiang Hsu, Ravi Gupta, Katie M. Campbell, Pascal Gellert, David Haussler, Jesse M. Zaretsky, Sofie R. Salama, Vanessa M. Hubbard-Lucey, Joel Greshock, Zeynep Kosaloglu Yalcin, Cornelis J. M. Melief, Priyanka Shah, Ioannis Xenarios, Nevena M. Ilic Raicevic, Andrew Lamb, Suchit Jhunjhunwala, Aly A. Khan, David Gfeller, James R. Heath, Richard Chen, Jia M. Chen, Alphonsus H. C. Ng, Elham Sherafat, Ana Belen Blazquez, Leo J. Lee, Beata Berent-Maoz, Cheryl Selinsky, Jasreet Hundal, Eduardo Cortes, Xengie Doan, Sahar Al Seesi, Adam Kolom, Fred Ramsdell, Nicolas Robine, Andrew J. Rech

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the param

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b788124c42a6ace5b9cb5efa2f3572c
https://resolver.caltech.edu/CaltechAUTHORS:20201019-121956456