Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lorenzo Casal"'
Autor:
Xandra Nuqui, Lorenzo Casalino, Ling Zhou, Mohamed Shehata, Albert Wang, Alexandra L. Tse, Anupam A. Ojha, Fiona L. Kearns, Mia A. Rosenfeld, Emily Happy Miller, Cory M. Acreman, Surl-Hee Ahn, Kartik Chandran, Jason S. McLellan, Rommie E. Amaro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications in the immunodomin
Externí odkaz:
https://doaj.org/article/a704a63cd3eb456bb8ed0bf429600777
Autor:
Nicholas S. Caron, William Casazza, Sara Mostafavi, Galen E.B. Wright, Mahmoud A. Pouladi, Jolene Ooi, Xiaohong Xu, Michael R. Hayden, Colin J. D. Ross, Lorenzo Casal, Bernard Ng
Publikováno v:
Human Molecular Genetics
Huntington disease (HD) is a neurodegenerative disorder that is caused by a CAG repeat expansion in HTT. The length of this repeat, however, only explains a proportion of the variability in age of onset in patients. Genome-wide association studies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e1708862a1779b6ffb575325092366
https://doi.org/10.1093/hmg/ddaa184
https://doi.org/10.1093/hmg/ddaa184
Autor:
Safia Ladha, Lorenzo Casal, Nicholas S. Caron, Dagmar E. Ehrnhoefer, Michael R. Hayden, Xiaofan Qiu
Publikováno v:
Cell Death Discovery, Vol 4, Iss 1, Pp 1-10 (2018)
Cell Death Discovery
Cell Death Discovery
Traditionally, the family of caspases has been subcategorised according to their respective main roles in mediating apoptosis or inflammation. However, recent studies have revealed that caspases participate in diverse cellular functions beyond their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf6a1618f1389023f87011c8489b737
http://link.springer.com/article/10.1038/s41420-018-0043-8
http://link.springer.com/article/10.1038/s41420-018-0043-8
Autor:
Sabine Waltl, Dagmar E. Ehrnhoefer, Boguslaw Felczak, Lorenzo Casal, Amber L. Southwell, Meenalochani Sivasubramanian, Lisa M. Anderson, Anita Fazeli, Xiaofan Qiu, Erika B. Villanueva, Yuanyun Xie, Michelle Tsang, Michael R. Hayden
Publikováno v:
Human Molecular Genetics. 27:239-253
Oxidative stress is a prominent feature of Huntington disease (HD), and we have shown previously that reduced levels of hace1 (HECT domain and Ankyrin repeat containing E3 ubiquitin protein ligase 1) in patient striatum may contribute to the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8162b1e4d2606c1c8c03bb5479382b0d
https://doi.org/10.1093/hmg/ddx394
https://doi.org/10.1093/hmg/ddx394
Autor:
Michael R. Hayden, Nicholas S. Caron, Bernard Ng, Colin J. D. Ross, Lorenzo Casal, Mahmoud A. Pouladi, Sara Mostafavi, Galen E.B. Wright, Jolene Ooi, Xiaohong Xu
Huntington disease (HD) is a neurodegenerative disorder that is caused by a CAG repeat expansion in the HTT gene. In an attempt to identify genomic modifiers that contribute towards the age of onset of HD, we performed a transcriptome wide associatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a524016d413ea801947330120b582b
https://doi.org/10.1101/699033
https://doi.org/10.1101/699033
Autor:
Hailey Findlay-Black, Nicholas S. Caron, Fiona Baine, Jennifer A. Collins, Chris Kay, Dulika S. Sumathipala, Luciana de Andrade Agostinho, Jacquie Greenberg, Amanda Krause, Carmen Lucia Antão Paiva, Ferdinando Squitieri, Vajira H. W. Dissanayake, Lorenzo Casal, Mario Cornejo-Olivas, Michael R. Hayden
Publikováno v:
Am J Hum Genet
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches targeting HTT SNPs now in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef346afafc6f60e7717eac01e5951a4
https://hdl.handle.net/20.500.12866/7499
https://hdl.handle.net/20.500.12866/7499
Publikováno v:
IEEE Access, Vol 11, Pp 84651-84669 (2023)
Masking constitutes a provably-secure approach against side-channel attacks. However, recombination effects (e.g., transitions) severely reduce the proven security. Concerning the software domain, CPU microarchitectures encompass techniques improving
Externí odkaz:
https://doaj.org/article/9b8273b2cb914655942ba5e44f713529
Autor:
Davide Costigliola, Lorenzo Casalino
Publikováno v:
Aerospace, Vol 10, Iss 12, p 1027 (2023)
The development of autonomous guidance control and navigation systems for spacecraft would greatly benefit applications such as debris removals or on-orbit servicing, where human intervention is not practical. Within this context, inspired by Autonom
Externí odkaz:
https://doaj.org/article/8c8fb5ab313344baa92a6586bbc5d7ca
Autor:
Sang Hoon Kim, Fiona L. Kearns, Mia A. Rosenfeld, Lorenzo Casalino, Micah J. Papanikolas, Carlos Simmerling, Rommie E. Amaro, Ronit Freeman
Publikováno v:
ACS Central Science, Vol 8, Iss 1, Pp 22-42 (2021)
Externí odkaz:
https://doaj.org/article/e3faa08be0d846a991916496b85dfe31
Autor:
Lorenzo Casalino, Zied Gaieb, Jory A. Goldsmith, Christy K. Hjorth, Abigail C. Dommer, Aoife M. Harbison, Carl A. Fogarty, Emilia P. Barros, Bryn C. Taylor, Jason S. McLellan, Elisa Fadda, Rommie E. Amaro
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1722-1734 (2020)
Externí odkaz:
https://doaj.org/article/e60b1ddf27e84d1fb235d7cde4477f45