Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Lorenzo Brunetti"'
Autor:
Lorenzo Brunetti, Giulia Pianigiani, Michael C. Gundry, Margaret A. Goodell, Brunangelo Falini
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 1028-1032 (2024)
Abstract Background NPM1‐mutated acute myeloid leukemia (AML) is the most frequent AML subtype. As wild‐type NPM1 is known to orchestrate ribosome biogenesis, it has been hypothesized that altered translation may contribute to leukemogenesis and
Externí odkaz:
https://doaj.org/article/18edd592c10b4daa81f70a17f80356e0
Autor:
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113484- (2023)
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent
Externí odkaz:
https://doaj.org/article/c6187d86919640fc8c826a912248ef14
Autor:
Brunangelo Falini, Maria Paola Martelli, Riccardo Rossi, Fabio Facchetti, Stefania Zini, Erica Borlenghi, Elena Sabbatini, Lorenzo Brunetti, Daniele Sorcini, Vincenzo Perriello, Enrico Tiacci, Bjorn Gjertsen, Vibeke Andresen
Publikováno v:
HemaSphere, Vol 7, p e7351787 (2023)
Externí odkaz:
https://doaj.org/article/2ff73fb54447455a87a3171c37fae5e5
Autor:
Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and t
Externí odkaz:
https://doaj.org/article/dac8c6aa736f4598a4966ab084bf32fc
Autor:
Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations
Externí odkaz:
https://doaj.org/article/6079e5ab657743e3ae91733b02a811e1
Publikováno v:
HemaSphere, Vol 4, Iss 6, p e499 (2020)
Externí odkaz:
https://doaj.org/article/f401fc3bb80e4e5ca6e73aef264892ed
Autor:
Yung-Hsin Huang, Jianzhong Su, Yong Lei, Lorenzo Brunetti, Michael C. Gundry, Xiaotian Zhang, Mira Jeong, Wei Li, Margaret A. Goodell
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background DNA methylation has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methyla
Externí odkaz:
https://doaj.org/article/9ad400dffd3b4ef1a26a5cb5c03bc9b5
Autor:
Michael C. Gundry, Lorenzo Brunetti, Angelique Lin, Allison E. Mayle, Ayumi Kitano, Dimitrios Wagner, Joanne I. Hsu, Kevin A. Hoegenauer, Cliona M. Rooney, Margaret A. Goodell, Daisuke Nakada
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1453-1461 (2016)
Summary: Our understanding of the mechanisms that regulate hematopoietic stem/progenitor cells (HSPCs) has been advanced by the ability to genetically manipulate mice; however, germline modification is time consuming and expensive. Here, we describe
Externí odkaz:
https://doaj.org/article/a84ef1ca22b448db80fbb63ddf1b86b6
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Autor:
Hannah J. Uckelmann, Elena L. Haarer, Reina Takeda, Eric M. Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei Chen, Scott A. Armstrong
Publikováno v:
Cancer Discovery. 13:746-765
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas