Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lorenzo Bozzelli"'
Autor:
Daniela Rodrigues-Amorim, P. Lorenzo Bozzelli, TaeHyun Kim, Liwang Liu, Oliver Gibson, Cheng-Yi Yang, Mitchell H. Murdock, Fabiola Galiana-Melendez, Brooke Schatz, Alexis Davison, Md Rezaul Islam, Dong Shin Park, Ravikiran M. Raju, Fatema Abdurrob, Alissa J. Nelson, Jian Min Ren, Vicky Yang, Matthew P. Stokes, Li-Huei Tsai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability of axons to
Externí odkaz:
https://doaj.org/article/8ebed6b59c0b464ab74100e9c4457c3e
Publikováno v:
Neural Plasticity, Vol 2018 (2018)
The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus ap
Externí odkaz:
https://doaj.org/article/0d8823fdc756419a9329d14230c32de1
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 103-104 (2019)
OBJECTIVES/SPECIFIC AIMS: Alzheimer’s disease (AD) is the leading cause of dementia, and a rapidly growing public health crisis as life expectancy increases. Two hallmark symptoms of the disease are memory impairment and the pathological accumulati
Externí odkaz:
https://doaj.org/article/8cd9308e099d40febf01215349a15e19
Autor:
Gwyneth M. Welch, Carles A. Boix, Eloi Schmauch, Jose Davila-Velderrain, Matheus B. Victor, Vishnu Dileep, P. Lorenzo Bozzelli, Qiao Su, Jemmie D. Cheng, Audrey Lee, Noelle S. Leary, Andreas R. Pfenning, Manolis Kellis, Li-Huei Tsai
Publikováno v:
Science Advances. 8
DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation associated with neurodegeneration. Here, we characterize DSB-bearing neurons from the CK-p25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085802828368af110af8132f15e35b9f
https://doi.org/10.1126/sciadv.abo4662
https://doi.org/10.1126/sciadv.abo4662
Autor:
Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsai
SummaryApolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e65379af953ea122df84bcbf9fcdeb2
https://doi.org/10.1101/2022.03.21.484146
https://doi.org/10.1101/2022.03.21.484146
Autor:
Gwyneth Welch, Carles Boix, Eloi Schmauch, Jose Davila-Velderrain, Matheus B. Victor, Vishnu Dileep, Lorenzo Bozzelli, Qiao Su, Jemmie Cheng, Audrey Lee, Noelle Leary, Andreas Pfenning, Manolis Kellis, Li-Huei Tsai
DNA double strand breaks (DSBs) are linked to aging, neurodegeneration, and senescence1,2. However, the role played by neurons burdened with DSBs in disease-associated neuroinflammation is not well understood. Here, we isolate neurons harboring DSBs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f75198fd9deae4fd1c2934c9a6fef54
https://doi.org/10.1101/2021.12.23.474002
https://doi.org/10.1101/2021.12.23.474002
Autor:
Jose Davila-Velderrain, Jun Wang, Fatima Gunter-Rahman, P. Lorenzo Bozzelli, Noah Pollak Milman, David A. Bennett, Fatema Abdurrob, Li-Huei Tsai, Cameron C. Parro, Ravikiran M. Raju, Scarlett J. Barker, Karim Abdelaal, Manolis Kellis
Publikováno v:
Science Translational Medicine. 13
Recent increases in human longevity have been accompanied by a rise in the incidence of dementia, highlighting the need to preserve cognitive function in an aging population. A small percentage of ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388da58599c44e2093eea1ef8cebbb47
https://doi.org/10.1126/scitranslmed.abd7695
https://doi.org/10.1126/scitranslmed.abd7695
Autor:
Chinnakkaruppan Adaikkan, Jun Wang, Karim Abdelaal, Steven J. Middleton, P. Lorenzo Bozzelli, Ian R. Wickersham, Thomas J. McHugh, Li-Huei Tsai
Publikováno v:
Neuron. 110:3091-3105.e9
A major pathological hallmark of neurodegenerative diseases, including Alzheimer's, is a significant reduction in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between anatomically corresponding bilat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2995f059f58697d366f9eb8585cf252
https://doi.org/10.1016/j.neuron.2022.07.023
https://doi.org/10.1016/j.neuron.2022.07.023
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
Much of the research in Alzheimer’s disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of cases. In contrast, this study used a late-onset AD model to examine the interaction between
Externí odkaz:
https://doaj.org/article/f8c9e1953dc446e1a053a508da7384c5
Autor:
Lorenzo Bozzelli, P.1,2, Alaiyed, Seham3, Kim, Eunyoung1, Villapol, Sonia1, Conant, Katherine1,2
Publikováno v:
Neural Plasticity. 2/4/2018, p1-13. 13p.