Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lorenzo, Spagnuolo"'
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 10 (2018)
Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells tightly interact with
Externí odkaz:
https://doaj.org/article/34182114361144ec9f4d7df56facc653
Autor:
Jérôme Widmer, Marco Bianchi, Christian Hotz, Noémie Boss, Lorenzo Spagnuolo, Viola Puddinu, Carole Bourquin, Thibaud Spinetti, Anne Oberson, Inès Mottas, Mariagrazia Uguccioni
Publikováno v:
European Journal of Immunology
High mobility group box‐1 protein (HMGB1) is an alarmin that, once released, promotes inflammatory responses, alone and as a complex with the chemokine CXCL12. Here, we report that the HMGB1–CXCL12 complex plays an essential role also in homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae575761a36c95a8a7d90fb832f1a96
http://europepmc.org/articles/PMC8453951
http://europepmc.org/articles/PMC8453951
Autor:
Chiara Secondini, Oriana Coquoz, Lorenzo Spagnuolo, Thibaud Spinetti, Sanam Peyvandi, Laura Ciarloni, Francesca Botta, Carole Bourquin, Curzio Rüegg
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumula
Externí odkaz:
https://doaj.org/article/fbfdb19146b946b08665b8ce3d54a712
Autor:
Olga S, Blomberg, Lorenzo, Spagnuolo, Hannah, Garner, Leonie, Voorwerk, Olga I, Isaeva, Ewald, van Dyk, Noor, Bakker, Myriam, Chalabi, Chris, Klaver, Maxime, Duijst, Kelly, Kersten, Marieke, Brüggemann, Dorien, Pastoors, Cheei-Sing, Hau, Kim, Vrijland, Elisabeth A M, Raeven, Daphne, Kaldenbach, Kevin, Kos, Inna S, Afonina, Paulien, Kaptein, Louisa, Hoes, Willemijn S M E, Theelen, Paul, Baas, Emile E, Voest, Rudi, Beyaert, Daniela S, Thommen, Lodewyk F A, Wessels, Karin E, de Visser, Marleen, Kok
Publikováno v:
Cancer cell.
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::858404ab7e5b5d36c2dd670afa56af35
https://pubmed.ncbi.nlm.nih.gov/36525971
https://pubmed.ncbi.nlm.nih.gov/36525971
Autor:
Emanuela Brunetto, Anna Maria Ferrara, Francesca Rampoldi, Anna Talarico, Elena DalCin, Greta Grassini, Lorenzo Spagnuolo, Isabella Sassi, Antonella Ferro, Lucia Veronica Cuorvo, Mattia Barbareschi, Sara Piccinin, Roberta Maestro, Lorenza Pecciarini, Claudio Doglioni, Maria Giulia Cangi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 6, Pp 579-590 (2013)
The CDC25A-CDK2 pathway has been proposed as critical for the oncogenic action of human epidermal growth factor receptor 2 (HER2) in mammary epithelial cells. In particular, transgenic expression of CDC25A cooperates with HER2 in promoting mammary tu
Externí odkaz:
https://doaj.org/article/1610277cf34842eebbe1fdd3cdb8d5a3
Autor:
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Brüggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A.M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S.M.E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F.A. Wessels, Karin E. de Visser, Marleen Kok
Publikováno v:
CANCER CELL
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad37e511061ec36826986b3010056ea
https://doi.org/10.1016/j.ccell.2022.11.014
https://doi.org/10.1016/j.ccell.2022.11.014
Autor:
Alessandra Cereghetti, Lorenzo Spagnuolo, Francesco Stellacci, Carole Bourquin, Ahmet Bekdemir, Yu-Sang Sabrina Yang, Marie Müller, Darrell J. Irvine, Inès Mottas
Publikováno v:
Biomaterials, Vol. 190-191 (2019) pp. 111-120
Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6fe3f7e2c291666e51ef04ab5b6334
http://doc.rero.ch/record/324118/files/mot_and.pdf
http://doc.rero.ch/record/324118/files/mot_and.pdf
Autor:
Laura Ciarloni, Thibaud Spinetti, Curzio Rüegg, Sanam Peyvandi, Carole Bourquin, Oriana Coquoz, Chiara Secondini, Francesca Botta, Lorenzo Spagnuolo
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf480b8b611d654371fe01262ba3866
https://doi.org/10.1080/2162402x.2017.1316437
https://doi.org/10.1080/2162402x.2017.1316437
Autor:
Carole Bourquin, Anne Oberson, Karola Rittner, Winfried Barchet, Lorenzo Spagnuolo, Viola Puddinu
Publikováno v:
Oncotarget
Oncotarget, Vol. 9, No 5 (2017) pp. 5641-5651
Oncotarget, Vol. 9, No 5 (2017) pp. 5641-5651
Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is crucial for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25b85cf6387b244f19d0f126deceb60
https://pubmed.ncbi.nlm.nih.gov/29464024
https://pubmed.ncbi.nlm.nih.gov/29464024