Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Lorenzo, Silengo"'
Autor:
Matteo Sorge, Giulia Savoré, Andrea Gallo, Davide Acquarone, Mauro Sbroggiò, Silvia Velasco, Federica Zamporlini, Saveria Femminò, Enrico Moiso, Giampaolo Morciano, Elisa Balmas, Andrea Raimondi, Gabrielle Nattenberg, Rachele Stefania, Carlo Tacchetti, Angela Maria Rizzo, Paola Corsetto, Alessandra Ghigo, Emilia Turco, Fiorella Altruda, Lorenzo Silengo, Paolo Pinton, Nadia Raffaelli, Nathan J Sniadecki, Claudia Penna, Pasquale Pagliaro, Emilio Hirsch, Chiara Riganti, Guido Tarone, Alessandro Bertero, Mara Brancaccio
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2450-2484 (2024)
Abstract Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective approaches to protect the heart. A physiologic level of ROS is produced in the heart by fatty acid oxidation, but stressful events can boost ROS and
Externí odkaz:
https://doaj.org/article/fbbe12027f6940b5871e50bcfc957a2f
Autor:
Monica Maccagno, Marta Tapparo, Gabriele Saccu, Letizia Rumiano, Sharad Kholia, Lorenzo Silengo, Maria Beatriz Herrera Sanchez
Publikováno v:
Medical Sciences, Vol 12, Iss 3, p 43 (2024)
The rise in biological therapies has revolutionized oncology, with immunotherapy leading the charge through breakthroughs such as CAR-T cell therapy for melanoma and B-ALL. Modified bispecific antibodies and CAR-T cells are being developed to enhance
Externí odkaz:
https://doaj.org/article/96f2969096fe4a7292b595a782e2b778
Autor:
Marta Tapparo, Gabriele Saccu, Chiara Pasquino, Valentina Fonsato, Claudio Medana, Valentina Schiavo, Enrica Mecarelli, Monica Maccagno, Lorenzo Silengo, Stefania Bruno, Giovanni Camussi, Maria Beatriz Herrera Sanchez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: The lack of functional hepatocytes poses a significant challenge for drug safety testing and therapeutic applications due to the inability of mature hepatocytes to expand and their tendency to lose functionality in vitro. Previous studi
Externí odkaz:
https://doaj.org/article/2297f9d0135249cba1b41372e9ebb979
Autor:
Arianna Ferro, Gabriele Saccu, Simone Mattivi, Andrea Gaido, Maria Beatriz Herrera Sanchez, Shafiul Haque, Lorenzo Silengo, Fiorella Altruda, Marilena Durazzo, Sharmila Fagoonee
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 277 (2024)
In recent years, EVs have emerged as promising vehicles for coding and non-coding RNAs (ncRNAs), which have demonstrated remarkable potential as biomarkers for various diseases, including chronic liver diseases (CLDs). EVs are small, membrane-bound p
Externí odkaz:
https://doaj.org/article/cbbb247c6ad3487a9e1fd84a390eb318
Autor:
Federica Fusella, Laura Seclì, Elena Busso, Anna Krepelova, Enrico Moiso, Stefania Rocca, Laura Conti, Laura Annaratone, Cristina Rubinetto, Maurizia Mello-Grand, Vijay Singh, Giovanna Chiorino, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Alessandro Morotti, Salvatore Oliviero, Isabella Castellano, Federica Cavallo, Paolo Provero, Guido Tarone, Mara Brancaccio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB a
Externí odkaz:
https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
Autor:
Giada Ingoglia, Can Martin Sag, Nikolai Rex, Lucia De Franceschi, Francesca Vinchi, James Cimino, Sara Petrillo, Stefan Wagner, Klaus Kreitmeier, Lorenzo Silengo, Fiorella Altruda, Lars S. Maier, Emilio Hirsch, Alessandra Ghigo, Emanuela Tolosano
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 69-76 (2017)
The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S
Externí odkaz:
https://doaj.org/article/d01bbc229583449697a09dc1ec64aec6
Autor:
Paola Defilippi, Guido Tarone, Emilia Turco, Fiorella Altruda, Lorenzo Silengo, Marina Glukhova, Guido Forni, Federica Cavallo, Riccardo Arisio, Anna Sapino, Isabella Castellano, Elena Ambrosino, Brigitte Bisarò, Paola Di Stefano, Agata Tinnirello, Sara Cabodi
Supplementary Materials and Figures 1-3 from p130Cas as a New Regulator of Mammary Epithelial Cell Proliferation, Survival, and HER2-Neu Oncogene–Dependent Breast Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f5dec44ea2a881a0be476ae75367a0
https://doi.org/10.1158/0008-5472.22366431.v1
https://doi.org/10.1158/0008-5472.22366431.v1
Autor:
Paola Defilippi, Guido Tarone, Emilia Turco, Fiorella Altruda, Lorenzo Silengo, Marina Glukhova, Guido Forni, Federica Cavallo, Riccardo Arisio, Anna Sapino, Isabella Castellano, Elena Ambrosino, Brigitte Bisarò, Paola Di Stefano, Agata Tinnirello, Sara Cabodi
To investigate the mechanisms through which p130Cas adaptor protein is linked to tumorigenesis, we generated mouse mammary tumor virus (MMTV)-p130Cas mice overexpressing p130Cas in the mammary gland. MMTVp130Cas transgenic mice are characterized by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f6685ec0e6c5f729d1488e4f196b2c
https://doi.org/10.1158/0008-5472.c.6495138.v1
https://doi.org/10.1158/0008-5472.c.6495138.v1
Autor:
Viviana Cernigliaro, Rossella Peluso, Beatrice Zedda, Lorenzo Silengo, Emanuela Tolosano, Rinaldo Pellicano, Fiorella Altruda, Sharmila Fagoonee
Publikováno v:
Cells, Vol 9, Iss 2, p 386 (2020)
Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of donor organs and risk of recidivism re
Externí odkaz:
https://doaj.org/article/439630b955b549daad0d3b6455412f6b
Autor:
Letizia De Chiara, Elvira Smeralda Famulari, Sharmila Fagoonee, Saskia K. M. van Daalen, Stefano Buttiglieri, Alberto Revelli, Emanuela Tolosano, Lorenzo Silengo, Ans M. M. van Pelt, Fiorella Altruda
Publikováno v:
Stem Cells International, Vol 2018 (2018)
Mesenchymal stem cells hold great promise for regenerative medicine as they can be easily isolated from different sources such as adipose tissue, bone marrow, and umbilical cord blood. Spontaneously arising pluripotent stem cells can be obtained in c
Externí odkaz:
https://doaj.org/article/659415803a0e4fbf994885f43924c753