HIV/HCV therapy with ledipasvir/sofosbuvir after randomized switch to emtricitabine-tenofovir alafenamide-based single-tablet regimens.

Autor: Gregory D Huhn, Moti Ramgopal, Mamta K Jain, Federico Hinestrosa, David M Asmuth, Jihad Slim, Deborah Goldstein, Shauna Applin, Julie H Ryu, Shuping Jiang, Stephanie Cox, Moupali Das, Thai Nguyen-Cleary, David Piontkowsky, Bill Guyer, Lorenzo Rossaro, Richard H Haubrich

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0224875 (2020)

IntroductionGuidelines advocate the treatment of HCV in all HIV/HCV co-infected individuals. The aim of this randomized, open-label study (ClinicalTrials.gov identifier: NCT02707601; https://clinicaltrials.gov/ct2/show/NCT02707601) was to evaluate th

Externí odkaz: https://doaj.org/article/17f99115a1574511a445b8925d582138

Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients(♦♦ Grant Support: This study was funded by Roche. The sponsor contributed to study design as well as data collection, analysis, and interpretation with input from the investigators. Writing support was provided by Blair Jarvis of Health Interactions and funded by Hoffman La-Roche Ltd. ClinicalTrials.gov Identifier: NCT00517439)

Autor: David R. Nelson, Stefan Zeuzem, Pietro Andreone, Peter Ferenci, Robert Herring, Donald M. Jensen, Patrick Marcellin, Paul J. Pockros, Maribel Rodríguez-Torres, Lorenzo Rossaro, Vinod K. Rustgi, Thomas Sepe, Mark Sulkowski, Isaac R. Thomason, Eric M. Yoshida, Anna Chan, George Hill

Publikováno v: Annals of Hepatology, Vol 11, Iss 1, Pp 15-31 (2012)

Introduction. Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). This phase 2, double-blind international trial evaluated the optimal treatment re

Externí odkaz: https://doaj.org/article/2d5eecb9e39e415a9b83005ddc1364ab

A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure

Autor: Oliver D. Tavabie, Constantine J. Karvellas, Siamak Salehi, Jaime L. Speiser, Christopher F. Rose, Krishna Menon, Andreas Prachalias, Michael A. Heneghan, Kosh Agarwal, William M. Lee, Mark J.W. McPhail, Varuna R. Aluvihare, W.M. Lee, Anne M. Larson, Iris Liou, Oren Fix, Michael Schilsky, Timothy McCashland, J. Eileen Hay, Natalie Murray, A. Obaid S. Shaikh, Andres Blei, Daniel Ganger, Atif Zaman, Steven H.B. Han, Robert Fontana, Brendan McGuire, Raymond T. Chung, Alastair Smith, Robert Brown, Jeffrey Crippin, Edwin Harrison, Adrian Reuben, Santiago Munoz, Rajender Reddy, R. Todd Stravitz, Lorenzo Rossaro, Raj Satyanarayana, Tarek Hassanein, Jodi Olson, Ram Subramanian, James Hanje, Bilal Hameed, Ezmina Lalani, Carla Pezzia, Corron Sanders, Nahid Attar, Linda S. Hynan, Valerie Durkalski, Wenle Zhao, Jaime Speiser, Catherine Dillon, Holly Battenhouse, Michelle Gottfried

Publikováno v: Journal of hepatology. 75(2)

Background & Aims Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world. Conventional prognostic models, utilising markers of liver injury and organ failure, lack sensitivity for mortality pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a43ba252019ddf9108b71a7986606fe
https://pubmed.ncbi.nlm.nih.gov/33857547

Clinical and Neurologic Outcomes in Acetaminophen-Induced Acute Liver Failure: A 21-Year Multicenter Cohort Study

Autor: Andrew J. MacDonald, Jaime L. Speiser, Daniel R. Ganger, Kathleen M. Nilles, Babak J. Orandi, Anne M. Larson, William M. Lee, Constantine J. Karvellas, Iris Liou, Oren Fix, Michael Schilsky, Timothy McCashland, J. Eileen Hay, Natalie Murray, A. Obaid S. Shaikh, Andres Blei, Daniel Ganger, Atif Zaman, Steven H.B. Han, null Robert Fontana, Brendan McGuire, Raymond T. Chung, Alastair Smith, Robert Brown, Jeffrey Crippin, Edwin Harrison, Adrian Reuben, Santiago Munoz, Rajender Reddy, R. Todd Stravitz, Lorenzo Rossaro, Raj Satyanarayana, Tarek Hassanein, Jodi Olson, Ram Subramanian, James Hanje, Bilal Hameed

Publikováno v: Clinical Gastroenterology and Hepatology. 19:2615-2625.e3

Acetaminophen (APAP)-induced acute liver failure (ALF) is a rare disease associated with high mortality rates. This study aimed to evaluate changes in interventions, psychosocial profile, and clinical outcomes over a 21-year period using data from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cec0126e3bcd44331d5d9d1da4dd41f
https://doi.org/10.1016/j.cgh.2020.09.016

Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver InjurySummary

Autor: Michael L. Schilsky, William M. Lee, Valerie Durkalski, Jody Rule, Raymond T. Chung, Daniel Ganger, Timothy J. Davern, Lorenzo Rossaro, Mary Jeanne Kreek, Joel Correa da Rosa, David G. Koch, Adrian Reuben, Robert J. Fontana, R. Todd Stravitz, Orna Levran, K. Rajender Reddy, Iris Liou, Brendan M. McGuire, Matthew Randesi, Julia D. Hankins, Oren K. Fix

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 3, Pp 500-505 (2017)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims: Acetaminophen-related acute liver injury and liver failure (ALF) result from ingestion of supratherapeutic quantities of this analgesic, frequently in association with other forms of substance abuse including alcohol, opioids, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6090c09696212854e78c08d6f90d26
http://www.sciencedirect.com/science/article/pii/S2352345X17300164