Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Lorenzo, Giacani"'
Autor:
Joseph J. Campo, Emily Romeis, Amit Oberai, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Adam D. Shandling, Amber Phan, Austin M. Haynes, Lorenzo Giacani
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110618- (2024)
Summary: Given the resurgence of syphilis, research endeavors to improve current assays for serological diagnosis and management of this disease are a priority. A proteome-scale platform for high-throughput profiling of the humoral response to Trepon
Externí odkaz:
https://doaj.org/article/a32660fe02d948409d1d2783e262ae2e
Autor:
Austin M. Haynes, Kelika A. Konda, Emily Romeis, Janet Siebert, Silver K. Vargas, Michael Reyes Diaz, Amber Phan, Carlos F. Caceres, Lorenzo Giacani, Jeffrey D. Klausner
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Syphilis is a multistage chronic sexually transmitted infection caused by the spirochete Treponema pallidum subsp. pallidum (T. pallidum). Today, syphilis is still endemic in low- and middle-income nations and has become resurgent in many hi
Externí odkaz:
https://doaj.org/article/3531bc9746234403b18e01808ff79eb2
Autor:
Emily Romeis, Nicole A P Lieberman, Barbara Molini, Lauren C Tantalo, Benjamin Chung, Quynh Phung, Carlos Avendaño, Anastassia Vorobieva, Alexander L Greninger, Lorenzo Giacani
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011259 (2023)
BackgroundThe TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions via non-reciprocal segmental gene conversion. These recombination events transfer
Externí odkaz:
https://doaj.org/article/3637a32b0e5d45cab49823cc0c655e9f
Autor:
Lorenzo Giacani
Publikováno v:
DST, Vol 34 (2022)
Research to identify a syphilis vaccine began shortly after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) strain in 1912 by Nichols and Hough and the identification of several possible animal models for the infection
Externí odkaz:
https://doaj.org/article/8f32d55171f74a1ea54698ee1d48dbe2
Autor:
Nicole A. P. Lieberman, Thaddeus D. Armstrong, Benjamin Chung, Daniel Pfalmer, Christopher M. Hennelly, Austin Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-ichi Nakayama, Kenichi Lee, Makoto Ohnishi, Kelika A. Konda, Silver K. Vargas, Maria Eguiluz, Carlos F. Caceres, Jeffrey D. Klausner, Oriol Mitja, Anne Rompalo, Fiona Mulcahy, Edward W. Hook, Irving F. Hoffman, Mitch M. Matoga, Heping Zheng, Bin Yang, Eduardo Lopez-Medina, Lady G. Ramirez, Justin D. Radolf, Kelly L. Hawley, Juan C. Salazar, Sheila A. Lukehart, Arlene C. Seña, Jonathan B. Parr, Lorenzo Giacani, Alexander L. Greninger
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Sequencing of most Treponema pallidum genomes excludes repeat regions in tp0470 and the tp0433 gene, encoding the acidic repeat protein (arp). As a first step to understanding the evolution and function of these genes and the proteins they encode, we
Externí odkaz:
https://doaj.org/article/f8331bd84d0e47898e3a5a42a1a23551
Autor:
Barbara Molini, Mark C. Fernandez, Charmie Godornes, Anastassia Vorobieva, Sheila A. Lukehart, Lorenzo Giacani
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of Treponema pallidum (Tp). The Tp species encompasses the highly related pallidum, pertenue, and endemi
Externí odkaz:
https://doaj.org/article/27f456d282b546e9908ea8ee2226ec2f
Autor:
Ethan Osias, Phoebe Hung, Lorenzo Giacani, Chrysovalantis Stafylis, Kelika A. Konda, Silver K. Vargas, E. Michael Reyes-Díaz, W. Scott Comulada, David A. Haake, Austin M. Haynes, Carlos F. Caceres, Jeffrey D. Klausner
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogen
Externí odkaz:
https://doaj.org/article/d503aab2ce0c4071902708f36beb001a
Autor:
Nicole A P Lieberman, Michelle J Lin, Hong Xie, Lasata Shrestha, Tien Nguyen, Meei-Li Huang, Austin M Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-Ichi Nakayama, Kenichi Lee, Makoto Ohnishi, Kelika A Konda, Silver K Vargas, Maria Eguiluz, Carlos F Caceres, Jeffrey D Klausner, Oriol Mitjà, Anne Rompalo, Fiona Mulcahy, Edward W Hook, Sheila A Lukehart, Amanda M Casto, Pavitra Roychoudhury, Frank DiMaio, Lorenzo Giacani, Alexander L Greninger
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010063 (2021)
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgen
Externí odkaz:
https://doaj.org/article/f8f88374a8944331bc4a55f2256ab665
Autor:
Michelle J Lin, Austin M Haynes, Amin Addetia, Nicole A P Lieberman, Quynh Phung, Hong Xie, Tien V Nguyen, Barbara J Molini, Sheila A Lukehart, Lorenzo Giacani, Alexander L Greninger
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009753 (2021)
Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of
Externí odkaz:
https://doaj.org/article/93670bd7706c4c12aeb62626826fc333
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009612 (2021)
Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The lack of genetic engineering tools has severely limited understanding of t
Externí odkaz:
https://doaj.org/article/2416de458b6342998c140c10f7ea5636