Výsledky vyhledávání - "Lorenzo, Di Cesare Mannelli"

Akademický článek

New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system

Autor: Laura Micheli, Stefania Nobili, Elena Lucarini, Alessandra Toti, Francesco Margiotta, Clara Ciampi, Daniel Venturi, Lorenzo Di Cesare Mannelli, Carla Ghelardini

Publikováno v: Pharmacological Research, Vol 209, Iss , Pp 107472- (2024)

Growing evidence suggests that opioid analgesics modulate angiogenesis during pathophysiological processes. Vascular endothelial growth factor-A (VEGF-A) was recently proposed to be involved in pain development. To date, no anti-angiogenic drug is us

Externí odkaz: https://doaj.org/article/03522dc81f774717a9f81b9b080149d2

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Akademický článek

Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

Autor: Elena Lucarini, Laura Benvenuti, Clelia Di Salvo, Vanessa D’Antongiovanni, Carolina Pellegrini, Giulia Valdiserra, Clara Ciampi, Luca Antonioli, Christian Lambiase, Lorenzo Cancelli, Antonio Grosso, Lorenzo Di Cesare Mannelli, Massimo Bellini, Carla Ghelardini, Matteo Fornai

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

IntroductionVisceral pain represents the most common digestive issue, frequently resulting from long-term inflammation, such as inflammatory bowel diseases. The lack of effective drugs prompted search of new therapeutic approaches. In this regard, ga

Externí odkaz: https://doaj.org/article/bf1182f9464e427895e057bd023e195d

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Akademický článek

Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

Autor: Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-3 (2024)

Externí odkaz: https://doaj.org/article/d12524d8a88b4fb8a2a5f9618be81508

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Akademický článek

Posidonia oceanica (L.) Delile Is a Promising Marine Source Able to Alleviate Imiquimod-Induced Psoriatic Skin Inflammation

Autor: Laura Micheli, Marzia Vasarri, Donatella Degl’Innocenti, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Antiga Emiliano, Alice Verdelli, Marzia Caproni, Emanuela Barletta

Publikováno v: Marine Drugs, Vol 22, Iss 7, p 300 (2024)

Psoriasis is a chronic immune-mediated inflammatory cutaneous disease characterized by elevated levels of inflammatory cytokines and adipokine Lipocalin-2 (LCN-2). Recently, natural plant-based products have been studied as new antipsoriatic compound

Externí odkaz: https://doaj.org/article/00b55b8320df4b89bc1a81a36962df4d

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Akademický článek

Performance of biomarkers NF-L, NSE, Tau and GFAP in blood and cerebrospinal fluid in rat for the detection of nervous system injury

Autor: Katerina Vlasakova, Takayuki Tsuchiya, Ivy N. Garfinkel, Michael P. Ruth, Cheryl Tyszkiewicz, Theodore J. Detwiler, Christopher J. Somps, Lorenzo Di Cesare Mannelli, Warren E. Glaab

Publikováno v: Frontiers in Neuroscience, Vol 17 (2024)

BackgroundTarget organ toxicity is often a reason for attritions in nonclinical and clinical drug development. Leveraging emerging safety biomarkers in nonclinical studies provides an opportunity to monitor such toxicities early and efficiently, pote

Externí odkaz: https://doaj.org/article/4d8d7f29be7c447e94c5af3685054aa9

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Akademický článek

Investigating epithelial-neuronal signaling contribution in visceral pain through colon organoid-dorsal root ganglion neuron co-cultures

Autor: Francesco Margiotta, Lorenzo Di Cesare Mannelli, Antonino Morabito, Carla Ghelardini, Elena Lucarini

Publikováno v: Neural Regeneration Research, Vol 19, Iss 6, Pp 1199-1200 (2024)

Externí odkaz: https://doaj.org/article/d4ee4ee4d45a40dfb5f195960625bbf3

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Akademický článek

DRG NEURONS SENSITIZATION IS INDUCED BY ALTERED COLON ORGANOIDS: A NOVEL IN VITRO MODEL TO MIMIC DYSBIOSIS-ASSOCIATED PAIN

Autor: Alessandra Toti, Elena Lucarini, Francesco Margiotta, Laura Micheli, Valentina Ferrara, Clara Ciampi, Daniel Venturi, Elisabetta Adamo, Lorenzo Curti, Lorenzo Di Cesare Mannelli, Carla Ghelardini

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S208-S209 (2023)

Externí odkaz: https://doaj.org/article/a32877c7c4d64c77826e91c858f059af

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Akademický článek

INTERFERON-GAMMA: A MASTER CYTOKINE IN ASTROGLIA-MEDIATED NEUROPROTECTION AGAINST OXALIPLATIN-INDUCED NEUROTOXICITY IN ORGANOTYPIC SPINAL CORD SLICES

Autor: Valentina Ferrara, Alessandra Toti, Carmen Parisio, Laura Micheli, Elena Lucarini, Clara Ciampi, Francesco Margiotta, Daniel Venturi, Elisabetta Adamo, Elisabetta Gerace, Gianluca Mattei, Carla Ghelardini, Lorenzo Di Cesare Mannelli

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S225-S226 (2023)

Externí odkaz: https://doaj.org/article/65cb00ebe30f4e44a5e980bcc25ed94e

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Akademický článek

The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

Autor: Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 930-939 (2022)

Human (h) carbonic anhydrase (CAs, EC 4.2.1.1) isoforms IX and XII were recently confirmed as anticancer targets against solid hypoxic tumours. The “three-tails approach” has been proposed as an extension of the forerunner “tail” and “dual-

Externí odkaz: https://doaj.org/article/412ee4b931a947cf9e44dab830b6bc29

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