Zobrazeno 1 - 10 of 104 pro vyhledávání: '"Lorenzo, Botta"'
1
Akademický článek
Modulation of the Antimelanoma Activity Imparted to Artemisinin Hybrids by the Monoterpene Counterpart
Autor: Elisa De Marchi, Silvia Filippi, Silvia Cesarini, Beatrice Di Maio, Bruno Mattia Bizzarri, Raffaele Saladino, Lorenzo Botta
Publikováno v: Molecules, Vol 29, Iss 14, p 3421 (2024)
Molecular hybridization is a widely used strategy in drug discovery and development processes that consists of the combination of two bioactive compounds toward a novel entity. In the current study, two libraries of hybrid derivatives coming from the
Externí odkaz: https://doaj.org/article/4ac5421e67b5437ba4624dbbb27031bb
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2
Akademický článek
Serendipitous Identification of Azine Anticancer Agents Using a Privileged Scaffold Morphing Strategy
Autor: Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Silvia Filippi, Eleonora Mancin, Lia Fiaschi, Elisa De Marchi, Federica Giammarino, Chiara Vagaggini, Bruno Mattia Bizzarri, Raffaele Saladino, Elena Dreassi, Maurizio Zazzi, Lorenzo Botta
Publikováno v: Molecules, Vol 29, Iss 7, p 1452 (2024)
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that enable
Externí odkaz: https://doaj.org/article/e3ec79e5c0fa472db93d562a43145464
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3
Akademický článek
Production and identification of two antifungal terpenoids from the Posidonia oceanica epiphytic Ascomycota Mariannaea humicola IG100
Autor: Lorenzo Botta, Raffaele Saladino, Paolo Barghini, Massimiliano Fenice, Marcella Pasqualetti
Publikováno v: Microbial Cell Factories, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Marine fungi are an important repository of bioactive molecules with great potential in different technological fields, the annual number of new compounds isolated from marine fungi is impressive and the general trend indicates th
Externí odkaz: https://doaj.org/article/1aac33c43b3046728c507577647826a8
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4
Akademický článek
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
Autor: Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi
Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 453 (2023)
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual
Externí odkaz: https://doaj.org/article/ccd671932b5b41839203be632d83a138
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6
Akademický článek
Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity
Autor: Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Massimiliano Secchi, Federica Giammarino, Ilenia Varasi, Camilla Lodola, Maurizio Zazzi, Elena Dreassi, Giovanni Maga, Lorenzo Botta, Raffaele Saladino
Publikováno v: Molecules, Vol 27, Iss 24, p 8829 (2022)
Current therapy against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified Nirmatrelvir 3. Unfortunately, these three drugs showed some limitations regar
Externí odkaz: https://doaj.org/article/c0abea2af9b042f980b54cd2f982ba34
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7
Akademický článek
A Green Blue LED-Driven Two-Liquid-Phase One-Pot Procedure for the Synthesis of Estrogen-Related Quinol Prodrugs
Autor: Elisa De Marchi, Lorenzo Botta, Bruno Mattia Bizzarri, Raffaele Saladino
Publikováno v: Molecules, Vol 27, Iss 24, p 8961 (2022)
Quinol derivatives of estrogens are effective pro-drugs in steroid replacement therapy. Here, we report that these compounds can be synthesized in one-pot conditions and high yield by blue LED-driven photo-oxygenation of parent estrogens. The oxidati
Externí odkaz: https://doaj.org/article/87f64effb16a4e4ca739aef2875512bc
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