Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Lorenzi, Tommaso"'
Populations are heterogeneous, deviating in numerous ways. Phenotypic diversity refers to the range of traits or characteristics across a population, where for cells this could be the levels of signalling, movement and growth activity, etc. Clearly,
Externí odkaz:
http://arxiv.org/abs/2410.13629
Autor:
Jiménez-Sánchez, Juan, Ortega-Sabater, Carmen, Maini, Philip K., Pérez-García, Víctor M., Lorenzi, Tommaso
Evolvability is defined as the ability of a population to generate heritable variation to facilitate its adaptation to new environments or selection pressures. In this article, we consider evolvability as a phenotypic trait subject to evolution and d
Externí odkaz:
http://arxiv.org/abs/2402.06392
A fundamental feature of collective cell migration is phenotypic heterogeneity which, for example, influences tumour progression and relapse. While current mathematical models often consider discrete phenotypic structuring of the cell population, in-
Externí odkaz:
http://arxiv.org/abs/2401.07279
Derivation and travelling wave analysis of phenotype-structured haptotaxis models of cancer invasion
We formulate haptotaxis models of cancer invasion wherein the infiltrating cancer cells can occupy a spectrum of states in phenotype space, ranging from `fully mesenchymal' to `fully epithelial'. The more mesenchymal cells are those that display stro
Externí odkaz:
http://arxiv.org/abs/2310.19933
Autor:
Leschiera, Emma, Al-Hity, Gheed, Flint, Melanie S., Venkataraman, Chandrasekhar, Lorenzi, Tommaso, Almeida, Luis, Audebert, Chloe
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the spheroids. Moreove
Externí odkaz:
http://arxiv.org/abs/2307.12627
Publikováno v:
Commun. Math. Sci., 22(8):2131-2165, 2024
We develop a new structured compartmental model for the coevolutionary dynamics between susceptible and infectious individuals in heterogeneous SI epidemiological systems. In this model, the susceptible compartment is structured by a continuous varia
Externí odkaz:
http://arxiv.org/abs/2306.16432
Many reaction-diffusion models produce travelling wave solutions that can be interpreted as waves of invasion in biological scenarios such as wound healing or tumour growth. These partial differential equation models have since been adapted to descri
Externí odkaz:
http://arxiv.org/abs/2302.11345
Autor:
Almeida, Luis, Denis, Jérôme, Ferrand, Nathalie, Lorenzi, Tommaso, Prunet, Antonin, Sabbah, Michéle, Villa, Chiara
Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of cancer cells in glucose-poor environments, allowing them to reuse lacta
Externí odkaz:
http://arxiv.org/abs/2301.08023
We present a spatial hybrid discrete-continuum modelling framework for the interaction dynamics between tumour cells and cytotoxic T cells, which play a pivotal role in the immune response against tumours. In this framework, tumour cells and T cells
Externí odkaz:
http://arxiv.org/abs/2207.09110
The capacity to aggregate through chemosensitive movement forms a paradigm of self-organisation, with examples spanning cellular and animal systems. A basic mechanism assumes a phenotypically homogeneous population that secretes its own attractant, w
Externí odkaz:
http://arxiv.org/abs/2206.14448