Zobrazeno 1 - 10
of 1 191
pro vyhledávání: '"Lorenzato A"'
Autor:
Giorgio Corti, Kristi Buzo, Enrico Berrino, Martina Miotto, Maria Costanza Aquilano, Marilena Lentini, Sara Erika Bellomo, Annalisa Lorenzato, Alice Bartolini, Gianluca Mauri, Luca Lazzari, Mariangela Russo, Federica Di Nicolantonio, Salvatore Siena, Silvia Marsoni, Caterina Marchiò, Alberto Bardelli, Sabrina Arena
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract The synthetic lethal effect observed with the use of PARP inhibitors (PARPi) with tumors characterized by the loss of key players in the homologous recombination (HR) pathway, commonly referred to as “BRCAness”, is maintaining high inter
Externí odkaz:
https://doaj.org/article/b04b94e061c24ffcaaac8ebf627bb2dd
Autor:
Valeria Pessei, Marco Macagno, Elisa Mariella, Noemi Congiusta, Vittorio Battaglieri, Paolo Battuello, Marco Viviani, Giulia Gionfriddo, Simona Lamba, Annalisa Lorenzato, Daniele Oddo, Fariha Idrees, Alessandro Cavaliere, Alice Bartolini, Simonetta Guarrera, Michael Linnebacher, Laura Monteonofrio, Luca Cardone, Michele Milella, Andrea Bertotti, Silvia Soddu, Elena Grassi, Giovanni Crisafulli, Alberto Bardelli, Ludovic Barault, Federica Di Nicolantonio
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of solid malignancies. Human tumors release cfDNA in the bloodstream th
Externí odkaz:
https://doaj.org/article/769e6f9e67d94058a19f60e264b16a42
Autor:
Dat P. Ha, Woo-Jin Shin, Ze Liu, Michael E. Doche, Roy Lau, Nektaria Maria Leli, Crystal S. Conn, Mariangela Russo, Annalisa Lorenzato, Constantinos Koumenis, Min Yu, Shannon M. Mumenthaler, Amy S. Lee
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Background Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial rol
Externí odkaz:
https://doaj.org/article/41b097963d3a4f95bc528fc71d41ad9c
The Project Optimus initiative by the FDA's Oncology Center of Excellence is widely viewed as a groundbreaking effort to change the $\textit{status quo}$ of conventional dose-finding strategies in oncology. Unlike in other therapeutic areas where mul
Externí odkaz:
http://arxiv.org/abs/2304.06164
Autor:
Elisa Mariella, Gaia Grasso, Martina Miotto, Kristi Buzo, Nicole Megan Reilly, Pietro Andrei, Pietro Paolo Vitiello, Giovanni Crisafulli, Sabrina Arena, Giuseppe Rospo, Giorgio Corti, Annalisa Lorenzato, Carlotta Cancelliere, Ludovic Barault, Giulia Gionfriddo, Michael Linnebacher, Mariangela Russo, Federica Di Nicolantonio, Alberto Bardelli
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1460-1485 (2024)
Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumors. We devised a novel computational workflow for transcriptome‐wide gene expression outlier analysis that allows the systematic identification of
Externí odkaz:
https://doaj.org/article/92bbd1f7992a4959a8ac49d3bf307ec5
Autor:
Ilja Oomen, Amal Abdi, Ricardo M. Camelo, Fábia M.R.A. Callado, Luany E.M. Carvalho, Ilenia L. Calcaterra, Manuel Carcao, Giancarlo Castaman, Jeroen C.J. Eikenboom, Kathelijn Fischer, Vivian K.B. Franco, Martijn W. Heymans, Frank W.G. Leebeek, David Lillicrap, Cláudia S. Lorenzato, Maria Elisa Mancuso, Davide Matino, Matteo N.D. Di Minno, Alex B. Mohseny, Johannes Oldenburg, Suely Meireles Rezende, Georges-Etienne Rivard, Natalia Rydz, Saskia E.M. Schols, Jan Voorberg, Karin Fijnvandraat, Samantha C. Gouw
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 7, Pp 102580- (2024)
Background: Inhibitor eradication to restore factor (F)VIII efficacy is the treatment goal for persons with severe hemophilia A (HA) and inhibitors. Immune tolerance induction (ITI) is demanding and successful in about 70% of people. Until now, it ha
Externí odkaz:
https://doaj.org/article/81986c3b0b0948108260f0f7bf03d9f4
Autor:
I Oomen, RM Camelo, M Carcao, G Castaman, JCJ Eikenboom, K Fischer, WG Frank Leebeek, D Lillicrap, ME Mancuso, D Matino, DMN Di Minno, AB Mohseny, J Oldenburg, SM Rezende, GE Rivard, N Rydz, S Schols, Voorberg Jan, FMRA Callado, LEM Carvalho, VKB Franco, CS Lorenzato, K Fijnvandraat, S Gouw
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S562-S563 (2024)
Background: Eradicating inhibitors to restore the effectiveness of Factor VIII (FVIII) is a desirable treatment goal for People with Severe Hemophilia A (PwSHA) and inhibitors, as this enables treatment of bleeding episodes with FVIII concentrates. H
Externí odkaz:
https://doaj.org/article/9a14647d2e784f2e9ac3886aafab9e62
Autor:
I Oomen, A Abdi, L Broer, RM Camelo, FMRA Callado, LEM Carvalho, IL Calcaterra, M Carcao, G Castaman, JCJ Eikenboom, K Fischer, VKB Franco, J Geissler, TW Kuijpers, FWG Leebeek, D Lillicrap, CS Lorenzato, ME Mancuso, D Matino, MND Di Minno, A Mo, AB Mohseny, SQ Nagelkerke, J Oldenburg, SM Rezende, K Fijnvandraat, S Gouw
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S564- (2024)
Immune Tolerance Induction (ITI) is the only treatment to eradicate inhibitors in people with Severe Hemophilia A (SHA). Successful ITI restores Factor VIII (FVIII) tolerance. ITI is demanding and successful in approximately 70% of people. Therefore,
Externí odkaz:
https://doaj.org/article/8a4854d5cc734792892446f0a32e01ce
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S815- (2024)
Introdução: A dengue é uma das doenças virais transmitidas por vetores mais importantes da atualidade. O Brasil vive sua maior epidemia da doença, onde a infecção pelo vírus da dengue (DENV) causa doenças que variam amplamente em severidade,
Externí odkaz:
https://doaj.org/article/86f9911dee264bbaaf601255eb7936d1
Autor:
Leandro Tavares da SILVA, Carolina Mendes FRUSCA-DO-MONTE, Gabriela Silva ALMEIDA, Victor Cordeiro da SILVA, Claudia Santos LORENZATO, Cristiane Baccin BENDO, José Vítor Nogara Borges MENEZES, Cassius Carvalho TORRES-PEREIRA, Fabian Calixto FRAIZ
Publikováno v:
Brazilian Oral Research, Vol 38 (2024)
Abstract The aim of this study was to evaluate the impact of oral conditions and health-related quality of life (HRQoL) on oral health-related quality of life (OHRQoL) in children and adolescents with blood coagulation disorders and hemoglobinopathie
Externí odkaz:
https://doaj.org/article/c7deb12d149445b9ad3a68b307150907