Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lorenza Di Ianni"'
Autor:
David Ruano-Gallego, Daniel A Yara, Lorenza Di Ianni, Gad Frankel, Stephanie Schüller, Luis Ángel Fernández
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1008031 (2019)
Enterohemorrhagic E. coli (EHEC) is a human intestinal pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. No vaccines or specific therapies are currently available to prevent or treat these infections. EHEC tightly attaches to th
Externí odkaz:
https://doaj.org/article/aeff96fc35b6470bac31e0e62c5345ca
Autor:
Marcella Manerba, Lorenza Di Ianni, Marzia Govoni, Antonietta Comparone, Giuseppina Di Stefano
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202588 (2018)
mTOR kinase and the A isoform of lactate dehydrogenase (LDH-A) are key players controlling the metabolic characteristics of cancer cells. By using cultured human breast cells as a "metabolic tumor" model, we attempted to explore the correlation betwe
Externí odkaz:
https://doaj.org/article/8a727c6be80f4c339fb3c55736e3ea6b
Publikováno v:
Future Medicinal Chemistry. 8:713-725
Lactate dehydrogenase (LDH) inhibition is considered a worthwhile attempt in the development of innovative anticancer strategies. Unfortunately, in spite of the involvement of several research institutions and pharma-companies, the discovery of LDH i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee345d4631574bb56b65ab4fb7ecc4a6
https://doi.org/10.4155/fmc.16.10
https://doi.org/10.4155/fmc.16.10
Autor:
Marzia Govoni, Giuseppina Di Stefano, Marcella Manerba, Antonietta Comparone, Lorenza Di Ianni
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 8, p e0202588 (2018)
PLoS ONE, Vol 13, Iss 8, p e0202588 (2018)
mTOR kinase and the A isoform of lactate dehydrogenase (LDH-A) are key players controlling the metabolic characteristics of cancer cells. By using cultured human breast cells as a “metabolic tumor” model, we attempted to explore the correlation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18a875a6e8b07c5759c0910244aecd7
http://europepmc.org/articles/PMC6107208
http://europepmc.org/articles/PMC6107208
Autor:
Tiziana Masini, Janet Robertson, Giuseppina Di Stefano, Andrea Cavalli, Federico Falchi, Saverio Minucci, Elisa Giacomini, Marinella Roberti, Roberto Pellicciari, Marcella Manerba, Isabella Pallavicini, Fulvia Farabegoli, Lorenza Di Ianni, Nicolas Boutard, Lara Rossini
Publikováno v:
ACS chemical biology. 12(10)
In BRCA2-defective cells, poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors can trigger synthetic lethality, as two independent DNA-repairing mechanisms are simultaneously impaired. Here, we have pharmacologically induced synthetic letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140415f3064e0bf0136b2916c785959b
https://pubmed.ncbi.nlm.nih.gov/28841282
https://pubmed.ncbi.nlm.nih.gov/28841282
Autor:
Marinella Roberti, Marzia Govoni, Maurizio Recanatini, Lorenza Di Ianni, Marcella Manerba, Giuseppina Di Stefano
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 105
In normal cells, heat shock response (HSR) is rapidly induced in response to a variety of harmful conditions and represents one of the most efficient defense mechanism. In cancer tissues, constitutive activation converts HSR into a life-threatening p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86b35cf4c325b0c3df050f95875194a
https://pubmed.ncbi.nlm.nih.gov/28501492
https://pubmed.ncbi.nlm.nih.gov/28501492
Autor:
Maurizio Recanatini, Marinella Roberti, Marcella Manerba, Marzia Govoni, Lorenza Di Ianni, Giuseppina Di Stefano
The inflammatory microenvironment is an essential component of neoplastic lesions and can significantly impact on tumor progression. Besides facilitating invasive growth, inflammatory cytokines were also found to reprogram cancer cell metabolism and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d80c1644e6f9927b80c71dc2bc326e
http://hdl.handle.net/11585/580126
http://hdl.handle.net/11585/580126
Autor:
Stephanie Schüller, Luis Ángel Fernández, David Ruano-Gallego, Gad Frankel, Lorenza Di Ianni, Daniel A Yara
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens, Vol 15, Iss 8, p e1008031 (2019)
PLoS Pathogens
instname
PLoS Pathogens, Vol 15, Iss 8, p e1008031 (2019)
PLoS Pathogens
Enterohemorrhagic E. coli (EHEC) is a human intestinal pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. No vaccines or specific therapies are currently available to prevent or treat these infections. EHEC tightly attaches to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1cf386e7578629b45f015da4a3593
https://doi.org/10.1371/journal.ppat.1008031
https://doi.org/10.1371/journal.ppat.1008031
Autor:
Marinella Roberti, Giuseppina Di Stefano, Marcella Manerba, Sebastiano Rupiani, Elisa Giacomini, Marina Vettraino, Federico Falchi, Matteo Masetti, Rosa Buonfiglio, Maurizio Recanatini, Lorenza Di Ianni
Glycolysis is drastically increased in tumors and it is the main route to energy production with a minor use of oxidative phosphorylation. Among the key enzymes in the glycolytic process, LDH is emerging as one of the most interesting targets for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d856d35197fb21a6b8fed4b0ad3a0c8b
http://hdl.handle.net/11585/517270
http://hdl.handle.net/11585/517270
Autor:
Luigi Fiume, Marinella Roberti, Marcella Manerba, Giuseppina Di Stefano, Lorenza Di Ianni, Maurizio Recanatini
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 74
Up-regulation of glycolysis, a well recognized hallmark of cancer cells, was also found to be predictive of poor chemotherapy response. This observation suggested the attempt of sensitizing cancer cells to conventional chemotherapeutic agents by inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4c1f67958d3032a40622e529dbcfac
https://pubmed.ncbi.nlm.nih.gov/25930121
https://pubmed.ncbi.nlm.nih.gov/25930121