The dual nature of DNA damage response in obesity and bariatric surgery-induced weight loss

Autor: David Israel Escobar Marcillo, Valeria Guglielmi, Grete Francesca Privitera, Michele Signore, Valeria Simonelli, Federico Manganello, Ambra Dell’Orso, Serena Laterza, Eleonora Parlanti, Alfredo Pulvirenti, Francesca Marcon, Ester Siniscalchi, Veronica Fertitta, Egidio Iorio, Rosaria Varì, Lorenza Nisticò, Mahara Valverde, Paolo Sbraccia, Eugenia Dogliotti, Paola Fortini

Publikováno v: Cell Death and Disease, Vol 15, Iss 9, Pp 1-11 (2024)

Abstract This novel study applies targeted functional proteomics to examine tissues and cells obtained from a cohort of individuals with severe obesity who underwent bariatric surgery (BS), using a Reverse-Phase Protein Array (RPPA). In obese individ

Externí odkaz: https://doaj.org/article/3578948ccd2843b68609d5962430311e

Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

Autor: Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret I. Boomsma, Thorkild I. A. Sørensen, Tellervo Korhonen, Jaakko Kaprio

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic

Externí odkaz: https://doaj.org/article/a04289e4c6684fb58b460af114fe9ff4

Psychiatric disorders among hospitalized patients deceased with COVID-19 in Italy

Autor: Ilaria Lega, Lorenza Nisticò, Luigi Palmieri, Emanuele Caroppo, Cinzia Lo Noce, Chiara Donfrancesco, Nicola Vanacore, Maria Luisa Scattoni, Angelo Picardi, Antonella Gigantesco, Silvio Brusaferro, Graziano Onder

Publikováno v: EClinicalMedicine, Vol 35, Iss , Pp 100854- (2021)

Background: there is concern about the increased risk for SARS-CoV-2 infection, COVID-19 severe outcomes and disparity of care among patients with a psychiatric disorder (PD). Based on the Italian COVID-19 death surveillance, which collects data from

Externí odkaz: https://doaj.org/article/71bd16990380461880522b734465e43f

Educational attainment of same-sex and opposite-sex dizygotic twins

Autor: Glen E. Duncan, Juan R. Ordoñana, Aline Jelenkovic, Esther Rebato, Amie E. Hwang, Wendy Cozen, Zengchang Pang, Weilong Li, Matthew Hotopf, Sisira Siribaddana, Leonie Helen Bogl, Dedra Buchwald, Robert F. Krueger, Brooke M. Huibregtse, Dorret I. Boomsma, Karri Silventoinen, Catherine Derom, Meike Bartels, Lucía Colodro-Conde, Ruth J. F. Loos, Catharina E. M. van Beijsterveldt, Athula Sumathipala, Jessica Tyler, Sarah E. Medland, Nicholas G. Martin, Fruhling Rijsdijk, Robert Vlietinck, Shandell Pahlen, Tracy L. Nelson, Kauko Heikkilä, Richard J. Rose, Anna K. Dahl Aslan, Thorkild I. A. Sørensen, Virgilia Toccaceli, Patrik K. E. Magnusson, Judy L. Silberg, John L. Hopper, Thomas M. Mack, Emanuela Medda, Grant W. Montgomery, Antti Latvala, Juan F. Sánchez-Romera, Qihua Tan, Dongfeng Zhang, Gonneke Willemsen, Matt McGue, Nancy L. Pedersen, Keith E. Whitfield, Jaakko Kaprio, Eero Vuoksimaa, Lorenza Nisticò, Christian Kandler, Hermine H. Maes, Robin P. Corley

Publikováno v: Silventoinen, K, Bogl, L H, Jelenkovic, A, Vuoksimaa, E, Latvala, A, Li, W, Tan, Q, Zhang, D, Pang, Z, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Willemsen, G, Bartels, M, van Beijsterveldt, C E M, Rebato, E, Corley, R P, Huibregtse, B M, Hopper, J L, Tyler, J, Duncan, G E, Buchwald, D, Silberg, J L, Maes, H H, Kandler, C, Cozen, W, Hwang, A E, Mack, T M, Nelson, T L, Whitfield, K E, Medda, E, Nisticò, L, Toccaceli, V, Krueger, R F, McGue, M, Pahlen, S, Martin, N G, Medland, S E, Montgomery, G W, Heikkilä, K, Derom, C A, Vlietinck, R F, Loos, R J F, Magnusson, P K E, Pedersen, N L, Dahl Aslan, A K, Hotopf, M, Sumathipala, A, Rijsdijk, F, Siribaddana, S H, Rose, R J, Sørensen, T I A, Boomsma, D I & Kaprio, J 2021, ' Educational attainment of same-sex and opposite-sex dizygotic twins : An individual-level pooled study of 19 twin cohorts ', Hormones and Behavior, vol. 136, 105054 . https://doi.org/10.1016/j.yhbeh.2021.105054
Hormones and Behavior, 136:105054, 1-6. Academic Press Inc.
Silventoinen, K, Bogl, L H, Jelenkovic, A, Vuoksimaa, E, Latvala, A, Li, W, Tan, Q, Zhang, D, Pang, Z, Ordoñana, J R, Sánchez-Romera, J F, Colodro-Conde, L, Willemsen, G, Bartels, M, van Beijsterveldt, C E M, Rebato, E, Corley, R P, Huibregtse, B M, Hopper, J L, Tyler, J, Duncan, G E, Buchwald, D, Silberg, J L, Maes, H H, Kandler, C, Cozen, W, Hwang, A E, Mack, T M, Nelson, T L, Whitfield, K E, Medda, E, Nisticò, L, Toccaceli, V, Krueger, R F, McGue, M, Pahlen, S, Martin, N G, Medland, S E, Montgomery, G W, Heikkilä, K, Derom, C A, Vlietinck, R F, Loos, R J F, Magnusson, P K E, Pedersen, N L, Dahl Aslan, A K, Hotopf, M, Sumathipala, A, Rijsdijk, F, Siribaddana, S H, Rose, R J, Sørensen, T I A, Boomsma, D I & Kaprio, J 2021, ' Educational attainment of same-sex and opposite-sex dizygotic twins : An individual-level pooled study of 19 twin cohorts ', Hormones and Behavior, vol. 136, 105054, pp. 1-6 . https://doi.org/10.1016/j.yhbeh.2021.105054

Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this design can be ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280cfd59d6f88ebb6dfbbb47722353a1
https://hdl.handle.net/1871.1/027eb347-4249-4292-b9e9-2049ed27b368

Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Autor: Mauro D'Amato, Alessia Fabbri, Barbara Porowska, Lorenza Nisticò, Koldo Garcia Etxebarria, Massimo Giambenedetti, Patrizia Spigaglia, Paolo Trentino, Andrea Oddi, Zaira Maroccia, Ida Luzzi, Fabrizio Barbanti, Elisabetta Delibato, Elena Angela Pia Germinario, Massimo Bonucci, Carla Fiorentini, G. Bruno, Slawomir Owczarek, Roberta De Angelis, Lupe Sanchez-Mete, Vittoria Stigliano, Gian Luca Grazi, Fabio Accarpio, Alfonso Piciocchi, Silvia Rossi

Publikováno v: Toxins
Toxins, Vol 13, Iss 569, p 569 (2021)
Volume 13
Issue 8

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ca7992c5a91b60114d535f552d2234
http://europepmc.org/articles/PMC8402601