Výsledky vyhledávání - "Lorenz R. B. Ponce"

Multiple Susceptibility Loci for Radiation-Induced Mammary Tumorigenesis in F2[Dahl S x R]-Intercross Rats

Autor: Victoria L. M. Herrera, Lorenz R. B. Ponce, Nelson Ruiz-Opazo

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e72143 (2013)

Although two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified accounting for 20% of breast cancer genetic risk, identification of other susceptibility genes accounting for 80% risk remains a challenge due to the complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059a0188eb155ce6af3e01cb0a1d6a3d
http://europepmc.org/articles/PMC3743793

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Distinct QTLs cosegregate with worse hypertension and renal disease in ovariectomized F2[Dahl S × R]-intercross rats

Autor: Nelson Ruiz-Opazo, Victoria L. M. Herrera, Lorenz R. B. Ponce, Yuichi Matsubara

Publikováno v: Journal of hypertension. 30(8)

OBJECTIVES Salt-sensitive hypertension is highly prevalent in postmenopausal women, with approximately 75% of postmenopausal women found to be hypertensive in the US. Insight from surgical menopause (ovariectomized) patients directly links the loss o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3fd151a3f4b22d741b8c28114233de
https://pubmed.ncbi.nlm.nih.gov/22688265

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Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats

Autor: Lorenz R. B. Ponce, Nelson Ruiz-Opazo, Victoria L. M. Herrera

Publikováno v: Journal of hypertension. 25(8)

Objective We documented susceptibility in Dahl S rats to coronary atherosclerosis upon the transgenic expression of human cholesteryl ester transfer protein (hCETP) producing severe combined hyperlipidemia, as detected in Tg[hCETP] 53 (Tg53) Dahl S r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e538493ba239f20ebfbe59e5bbb56c
https://pubmed.ncbi.nlm.nih.gov/17620956

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Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats

Autor: Aristides Tsikoudakis, Nelson Ruiz-Opazo, Yuichi Matsubara, Victoria L. M. Herrera, Lorenz R. B. Ponce

Publikováno v: Physiological genomics. 26(3)

Sex-specific differences in polygenic (essential) hypertension are commonly attributed to the role of sex steroid hormone-receptor systems attenuating sex-common disease mechanisms in premenopausal women. However, emerging observations indicate sex-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e524a36f4887c2d0764429fb4bb7e255
https://pubmed.ncbi.nlm.nih.gov/16720678

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Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis

Autor: Pia Bagamasbad, Victoria L. M. Herrera, Lorenz R. B. Ponce, Nelson Ruiz-Opazo, Benjamin D. VanPelt, Tamara Didishvili

Publikováno v: Physiological genomics. 23(3)

The dual endothelin-1/angiotensin II receptor (Dear) binds endothelin-1 (ET-1) and angiotensin II (ANG II) with equal affinities in the Dahl S/JRHSrat strain. To elucidate its physiological significance within the context of multiple receptor isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f91528f9b8c4eded7bf5963b85992f
https://pubmed.ncbi.nlm.nih.gov/16293765

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Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats

Autor: P. I. A. Bagamasbad, Lorenz R. B. Ponce, Nelson Ruiz-Opazo, Lyle V. Lopez, Kenneth S. Kosik, Victoria L. M. Herrera

Publikováno v: Molecular medicine (Cambridge, Mass.). 10(1-6)

Alzheimer's disease (AD) is characterized by increased beta amyloid (Abeta) levels, extracellular Abeta deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the physiological role of normal levels of Abeta and its parent p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a6499528fd14e2df85d51542ef7895
https://pubmed.ncbi.nlm.nih.gov/15502881

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Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model

Autor: Aristides Tsikoudakis, Haya Herscovitz, Nelson Ruiz-Opazo, Victoria L. M. Herrera, Pia Bagamasbad, Donald L. Gantz, Arie van Tol, Lorenz R. B. Ponce, Tamara Didishvili

Publikováno v: Atherosclerosis, 177(1), 9-18. Elsevier Ireland Ltd

Epidemiological and clinical data demonstrate differences in atherosclerotic coronary heart disease prevalence between age-matched men and premenopausal women. Mechanisms underlying relative athero-susceptibility in men and athero-resistance in preme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9814557dfc1228427418c4df46e80812
https://pubmed.ncbi.nlm.nih.gov/15488860

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