Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Lorenz M. Mayr"'
Autor:
Erwin De Genst, Kylie S. Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R. S. Kolstad, William E. Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M. Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson, James Hunt, Kenneth R. Chien
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors use modified RNA and VHH libraries to generate intrabodies that target dysregulated interactions between two calcium handling proteins in failing cardiomyocytes. Heart specific expression of the intrabodies in a murine heart failure
Externí odkaz:
https://doaj.org/article/41820d2e39ea4787978141037e15dc1e
Autor:
Mei Ding, Rajneesh Malhotra, Tomas Ottosson, Magnus Lundqvist, Aman Mebrahtu, Johan Brengdahl, Ulf Gehrmann, Elisabeth Bäck, Douglas Ross-Thriepland, Ida Isaksson, Björn Magnusson, Kris F. Sachsenmeier, Hanna Tegel, Sophia Hober, Mathias Uhlén, Lorenz M. Mayr, Rick Davies, Johan Rockberg, Lovisa Holmberg Schiavone
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Regulatory T cells (Tregs) are the key cells regulating peripheral autoreactive T lymphocytes. Tregs exert their function by suppressing effector T cells. Tregs have been shown to play essential roles in the control of a variety of physiolog
Externí odkaz:
https://doaj.org/article/3192eee1ef58427faaa5eafd5d5b98ec
Autor:
Xabier Osteikoetxea, Andreia Silva, Elisa Lázaro‐Ibáñez, Nikki Salmond, Olga Shatnyeva, Josia Stein, Jan Schick, Stephen Wren, Julia Lindgren, Mike Firth, Alexandra Madsen, Lorenz M. Mayr, Ross Overman, Rick Davies, Niek Dekker
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 5, Pp n/a-n/a (2022)
Abstract Extracellular vesicles (EVs) have shown promise as biological delivery vehicles, but therapeutic applications require efficient cargo loading. Here, we developed new methods for CRISPR/Cas9 loading into EVs through reversible heterodimerizat
Externí odkaz:
https://doaj.org/article/4a8bdd5ba4bc4514895ce03bd1082822
Autor:
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be
Externí odkaz:
https://doaj.org/article/8d05a4aa843b419591409ca746b331db
Autor:
Alba Carreras, Luna Simona Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz M. Mayr, Rosie Perkins, Daniel Lindén, Jan Borén, Mohammad Bohlooly-Y, Marcello Maresca
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeo
Externí odkaz:
https://doaj.org/article/c78e539e95c14e998f30f49acc7e488d
Autor:
Lydia A. Strukova, Dmitriy M. Chudakov, Olga V. Britanova, Lorenz M. Mayr, Thomas Stettler, Marco Meyerhofer, Felix Freuler, May Marsh, Wilhelm Stark, Ekaterina A. Souslova, Lukas Leder
Publikováno v:
Sensors, Vol 10, Iss 9, Pp 8143-8160 (2010)
Here we report the first crystal structure of a high-contrast genetically encoded circularly permuted green fluorescent protein (cpGFP)-based Ca2+ sensor, Case16, in the presence of a low Ca2+ concentration. The structure reveals the positioning of t
Externí odkaz:
https://doaj.org/article/52b012813ad240e49e7016e54c7cfe43
Publikováno v:
BioTechniques, Vol 36, Iss 1, Pp 80-83 (2004)
Recombinant baculoviruses derived from the Autographa californica nuclear polyhedrosis virus (AcNPV) are widely used to express heterologous genes in insect cells, but the use of the baculovirus expression vector system (BEVS) is hampered by slow and
Externí odkaz:
https://doaj.org/article/c801ec1099ed45d79f9d66da2be2c5b6
Autor:
Frank Seeliger, Carla P. Martins, Emily James, Sandra Wimberger, Camilla Johansson, Mohammad Bohlooly-Y, Emma J. Davies, Maryam Clausen, Lukas Badertscher, Michelle J. Porritt, Simon T. Barry, Xiufeng Xu, Anna Schantz, Roberto Nitsch, Amir Taheri-Ghahfarokhi, Marcello Maresca, Himjyot Jaiswal, Elizabeth Hardaker, Jenna Bradley, Babak Alaeimahabadi, Lorenz M. Mayr, Abdel Wahad Bidar, Therese Admyre, Anders Lundin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still expensive and time-consuming, demanding more target flexibility and faster turnaround times
Autor:
Tomas Ottosson, Rick Davies, Elisabeth Bäck, Lovisa Holmberg Schiavone, Mathias Uhlén, Johan Rockberg, Kris Sachsenmeier, Hanna Tegel, Mei Ding, Johan Brengdahl, Ulf Gehrmann, Lorenz M. Mayr, Björn Magnusson, Sophia Hober, Ida Isaksson, Rajneesh Malhotra, Aman Mebrahtu, Magnus Lundqvist, Douglas Ross-Thriepland
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Regulatory T cells (Tregs) are the key cells regulating peripheral autoreactive T lymphocytes. Tregs exert their function by suppressing effector T cells. Tregs have been shown to play essential roles in the control of a variety of physiological and
Autor:
Magnus Althage, Luna Simona Pane, Frank Seeliger, Mikael Bjursell, Ralph Knöll, Daniel Lindén, Katja Madeyski-Bengtson, Marta Perez-Alcazar, Roberto Nitsch, Mohammad Bohlooly-Y, Ryan Hicks, Alba Carreras, Marcello Maresca, Rosie Perkins, Jan Borén, Amir Taheri-Ghahfarokhi, Lorenz M. Mayr, Elke Ericson, Michelle J. Porritt, Pinar Akcakaya
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Biology
BMC Biology
Background Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, h