Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lorenz Herdeis"'
Autor:
Joachim Bröker, Alex G. Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R. Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B. McConnell, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 65:14614-14629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c212d783bab500794ca19ea0996c93
https://doi.org/10.1021/acs.jmedchem.2c01120
https://doi.org/10.1021/acs.jmedchem.2c01120
Autor:
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I. Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y. Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B. McConnell, Norbert Kraut, Piro Lito
Publikováno v:
Nature.
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been the development of covalent allele-specific inhibitors that trap KRAS G1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409e1bd71739f2699717b05ba38036b5
https://doi.org/10.1038/s41586-023-06123-3
https://doi.org/10.1038/s41586-023-06123-3
Publikováno v:
Current Opinion in Structural Biology. 71:136-147
It has taken four decades of research to see the first major breakthrough for KRAS-driven cancers. In particular, the last decade has seen a paradigm shift with the discovery of druggable pockets on KRAS and clinical efficacy with covalent KRASG12C i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bb5b3a1a291685f2e909b51f82521a
https://doi.org/10.1016/j.sbi.2021.06.013
https://doi.org/10.1016/j.sbi.2021.06.013
Autor:
Lorenz Herdeis, Andrea Vasella, Daniel Egli, David Touboul, Martina Schulze-Adams, Bruno Bernet
Publikováno v:
Helvetica Chimica Acta. 97:1244-1268
The G[s]G dinucleoside 6 and the G[s]G* dinucleoside 8 were prepared by alkylation of the guanosine thiols derived from 2 and 5, respectively, by the C(8)-chloromethylated guanosine 4 that was obtained from alcohol 3. Dinucleosides 6 and 8 were deacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe38dc876dc62d8e473596220365ab38
https://doi.org/10.1002/hlca.201400175
https://doi.org/10.1002/hlca.201400175
Publikováno v:
Helvetica Chimica Acta. 96:1235-1265
The protected G*[s]C*[s]U*[s]A*[s]U*[s]A*[s]G*[s]C* octanucleoside 24 was prepared by S-alkylation of the thiolate derived from tetranucleoside 23 with the methanesulfonate 22, and transformed to the silylated and isopropylidenated 25, and further in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06dd7ac5f1946ea1253c053ef421ca90
https://doi.org/10.1002/hlca.201300043
https://doi.org/10.1002/hlca.201300043
Autor:
Bruno Bernet, Lorenz Herdeis, André W. Brändli, Anu Augustine, Andrea Vasella, Roland E. Kälin
Publikováno v:
Helvetica Chimica Acta. 94:545-577
The (chloromethyl)cytidine 7 was obtained from alcohol 4 that was synthesized from the protected cytidine 3 by C(6)-formylation and reduction. Thioacetate 10 was obtained from the cytidine 2, and thioacetate 8 from a Mitsunobu reaction of alcohol 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5e405a4a5ec3474b516a5d9e70ee36
https://doi.org/10.1002/hlca.201000451
https://doi.org/10.1002/hlca.201000451
Autor:
Kay Severin, Peter Mayer, Marie-Line Lehaire, Kurt Polborn, Lorenz Herdeis, Rosario Scopelliti
Publikováno v:
Inorganic Chemistry. 43:1609-1617
The reaction of [(arene)RuCl(2)](2) (arene = cymene, 1,3,5-C(6)H(3)Me(3)) and [CpRhCl(2)](2) half-sandwich complexes with tridentate heterocyclic ligands in the presence of base has been investigated. In all cases, the chloro-ligands were substituted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854ffdb68c46bcbe811993379c896118
https://doi.org/10.1021/ic035328i
https://doi.org/10.1021/ic035328i
Autor:
Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I., Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y., Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben
Publikováno v:
Nature; Jul2023, Vol. 619 Issue 7968, p160-166, 7p
Autor:
Schulze-Adams, Martina1, Bernet, Bruno1, Egli, Daniel1, Herdeis, Lorenz1, Vasella, Andrea1, Touboul, David1,2
Publikováno v:
Helvetica Chimica Acta. Sep2014, Vol. 97 Issue 9, p1244-1268. 25p.
Publikováno v:
Helvetica Chimica Acta. Jul2013, Vol. 96 Issue 7, p1235-1265. 31p.