Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Lorenz H Lehmann"'
Autor:
Felix Korell, Lukas Entenmann, Sebastian Romann, Evangelos Giannitsis, Anita Schmitt, Carsten Müller-Tidow, Norbert Frey, Peter Dreger, Michael Schmitt, Lorenz H Lehmann
Publikováno v:
EClinicalMedicine, Vol 69, Iss , Pp 102504- (2024)
Summary: Background: Assessment of cardiovascular risk is critical for patients with cancer. Previous retrospective studies suggest potential cardiotoxicity of CAR T cell therapies. We aimed to prospectively assess cardiotoxicity and the predictive v
Externí odkaz:
https://doaj.org/article/073119b3fda1485ab34c0e1b991554bd
Autor:
Henrike Tscheschner, Eric Meinhardt, Philipp Schlegel, Andreas Jungmann, Lorenz H Lehmann, Oliver J Müller, Patrick Most, Hugo A Katus, Philip W Raake
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215992 (2019)
The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic reticulum (SR) Ca2+ leak. The chaperone Glucose regulated protein 78 (GRP78) is important f
Externí odkaz:
https://doaj.org/article/cba7c602f18643f6a82f9c5e90c7e73f
Autor:
Michael M Kreusser, Lorenz H Lehmann, Markus Haass, Sebastian J Buss, Hugo A Katus, Dirk Lossnitzer
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172070 (2017)
In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release. Re
Externí odkaz:
https://doaj.org/article/e87464356dc84b59b3e089bdcdc29c29
Autor:
Martin Weinreuter, Michael M Kreusser, Jan Beckendorf, Friederike C Schreiter, Florian Leuschner, Lorenz H Lehmann, Kai P Hofmann, Julia S Rostosky, Nathalie Diemert, Chang Xu, Hans Christian Volz, Andreas Jungmann, Alexander Nickel, Carsten Sticht, Norbert Gretz, Christoph Maack, Michael D Schneider, Hermann‐Josef Gröne, Oliver J Müller, Hugo A Katus, Johannes Backs
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1231-1245 (2014)
Abstract CaMKII was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. Here, we investigated the roles of different CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury by the use of new genetic CaMKII
Externí odkaz:
https://doaj.org/article/e4120ad81f884f1e95c8a587fe170563
Autor:
Selina J Hein, Lorenz H Lehmann, Mandy Kossack, Lonny Juergensen, Dieter Fuchs, Hugo A Katus, David Hassel
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122665 (2015)
Translucent zebrafish larvae represent an established model to analyze genetics of cardiac development and human cardiac disease. More recently adult zebrafish are utilized to evaluate mechanisms of cardiac regeneration and by benefiting from recent
Externí odkaz:
https://doaj.org/article/307822938b004fdea97560a06c316575
Autor:
Roland Veltkamp, Stefan Uhlmann, Marilena Marinescu, Carsten Sticht, Daniel Finke, Norbert Gretz, Herrmann‐Josef Gröne, Hugo A. Katus, Johannes Backs, Lorenz H. Lehmann
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 54-62 (2019)
Abstract Background Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimen
Externí odkaz:
https://doaj.org/article/4ee6e77f3fe14839a1616c6e00904b7a
Autor:
Sebastian W. Romann, Daniel Finke, Markus B. Heckmann, Hauke Hund, Evangelos Giannitsis, Hugo A. Katus, Norbert Frey, Lorenz H. Lehmann
AimsOncological patients suspected to have the risk for cardiotoxicity, are recommended to be under intensified cardiological surveillance. We aimed to investigate the value of cardiac biomarker and patient-related risk factors (age, cardiovascular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2406691890611c3c90375a3d139afb4c
https://doi.org/10.1101/2023.05.05.23289440
https://doi.org/10.1101/2023.05.05.23289440
Autor:
Christoph Gumbinger, Lorenz H. Lehmann, Laura Bettina Jäger, Brigitte Wildemann, Florian Andre, Andrea Viehöver, Paul Schnitzler, Norbert Frey, Sven Jarius
Publikováno v:
Journal of Neurology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6598ca27c87ad4a102bf3373d756c11
https://doi.org/10.1007/s00415-021-10779-0
https://doi.org/10.1007/s00415-021-10779-0
Autor:
Yaohua Zhang, Chengcao Sun, Yajuan Li, Juan Qin, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Zilong Zhao, Andrew Wu, Yutao Xi, Jun Yao, Mien-Chie Hung, George A. Calin, Jie Cheng, Bora Lim, Lorenz H. Lehmann, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang, Javid J. Moslehi, Chunru Lin
Publikováno v:
Science translational medicine, vol 14, iss 669
Sci Transl Med
Sci Transl Med
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti–programmed cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4f4f53abc43bc63e2a0e5f1fb52ead
https://escholarship.org/uc/item/3qk6x9mk
https://escholarship.org/uc/item/3qk6x9mk
Autor:
Lorenz H. Lehmann, Markus B. Heckmann, Guillaume Bailly, Daniel Finke, Frederic Stein, John R Power, Marie Bretagne, Stephane Ederhy, Charlotte Fenioux, Adrien Procureur, Omar Hamwy, Bruno Pinna, Emanuela Romano, Yves Allenbach, Nicolas L. Palaskas, Hugo A. Katus, Thomas Similowski, Evangelos Giannitsis, Norbert Frey, Ziya Kaya, Javid Moslehi, Joe-Elie Salem
Background: Immune-checkpoint inhibitors (ICI) are approved for multiple cancers but can result in ICI-associated myocarditis, an infrequent but life-threatening condition. Elevations in cardiac biomarkers, troponin-I (cTnI), troponin-T (cTnT) and cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1126d2ea63054851c07040f5ec80ff
https://doi.org/10.21203/rs.3.rs-2030687/v1
https://doi.org/10.21203/rs.3.rs-2030687/v1