Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lorenz C. Blum"'
Publikováno v:
CHIMIA, Vol 65, Iss 11 (2011)
Organic small molecules are of particular interest for medicinal chemistry since they comprise many biologically active compounds which are potential drugs. To understand this vast chemical space, we are enumerating all possible organic molecules to
Externí odkaz:
https://doaj.org/article/8229694978aa4f2b83a34a98d4f71154
Autor:
Yansheng Liu, Alfonso Buil, Ben C Collins, Ludovic CJ Gillet, Lorenz C Blum, Lin‐Yang Cheng, Olga Vitek, Jeppe Mouritsen, Genevieve Lachance, Tim D Spector, Emmanouil T Dermitzakis, Ruedi Aebersold
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 2, Pp 1-18 (2015)
Abstract The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to d
Externí odkaz:
https://doaj.org/article/1f824790b47942e1aee2d6e5fce7ddf5
Publikováno v:
Environmental science. Processesimpacts. 19(3)
Ozonation of secondary wastewater effluents can reduce the discharge of micropollutants by transforming their chemical structures. Therefore, a better understanding of the formation of transformation products during ozonation is important. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014aa9d9bb4667a9e2e816ef5306a9a4
https://pubmed.ncbi.nlm.nih.gov/28191571
https://pubmed.ncbi.nlm.nih.gov/28191571
Autor:
Lars Malmström, Witold Wolski, Bernd Rinn, Chandrasekhar Ramakrishnan, Adam Srebniak, Franz-Josef Elmer, Lorenz C. Blum, Peter Z. Kunszt, Béla Hullár, Emanuel Schmid, Andreas Quandt
Publikováno v:
Concurrency and Computation: Practice and Experience. 27:433-445
Summary Development of workflow and data management systems are challenging because of the need to provide a service for users with varying degrees of expertise from novices to experts with more knowledge than the developers. We have received feedbac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d43c526c4d6c04da35f7de73735912b
https://doi.org/10.1002/cpe.3294
https://doi.org/10.1002/cpe.3294
Publikováno v:
Journal of Chemical Information and Modeling
The chemical universe database GDB-17 contains 166.4 billion molecules of up to 17 atoms of C, N, O, S, and halogens obeying rules for chemical stability, synthetic feasibility, and medicinal chemistry. GDB-17 was analyzed using 42 integer value desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c12a8df6edc7e2c7f01033664ba3f5
https://doi.org/10.1021/ci300535x
https://doi.org/10.1021/ci300535x
Autor:
Lorenz C. Blum, Milena Mayer, Sonia Bertrand, Jean-Louis Reymond, Daniel Bertrand, Ruud van Deursen, Justus J. Bürgi
Publikováno v:
J. Chem. Inf. Model
The chemical universe database GDB-13 enumerates 977 million organic molecules up to 13 atoms of C, N, O, Cl, and S that are virtually possible following simple rules for chemical stability and synthetic feasibility. Analogs of nicotine were identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb9bf4b48df87255d2655ef78f39ca0
https://doi.org/10.1021/ci200410u
https://doi.org/10.1021/ci200410u
Autor:
Ludovic C Gillet, Wolfram Jochum, Witold Wolski, Markus Joerger, George Rosenberger, Tiannan Guo, Ruedi Aebersold, Silke Gillessen, Lorenz C. Blum, Ching Chiek Koh, Ben C. Collins, Petri Kouvonen, Hannes L. Röst
Publikováno v:
Guo, T, Kouvonen, P, Koh, C C, Gillet, L C, Wolski, W E, Röst, H L, Rosenberger, G, Collins, B C, Blum, L C, Gillessen, S, Joerger, M, Jochum, W & Aebersold, R 2015, ' Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps ', Nature Medicine, vol. 21, no. 4, pp. 407-415 . https://doi.org/10.1038/nm.3807
Nature medicine
Nature medicine
Clinical specimens are each inherently unique, limited and nonrenewable. Small samples such as tissue biopsies are often completely consumed after a limited number of analyses. Here we present a method that enables fast and reproducible conversion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4718cd6db681c4d2f4e2a1f4fde94d11
https://pure.qub.ac.uk/en/publications/rapid-mass-spectrometric-conversion-of-tissue-biopsy-samples-into-permanent-quantitative-digital-proteome-maps(dcd4afbc-e579-41f7-af38-52be68273f73).html
https://pure.qub.ac.uk/en/publications/rapid-mass-spectrometric-conversion-of-tissue-biopsy-samples-into-permanent-quantitative-digital-proteome-maps(dcd4afbc-e579-41f7-af38-52be68273f73).html
Autor:
Alfonso Buil, Lin-Yang Cheng, Ruedi Aebersold, Jeppe Mouritsen, Ben C. Collins, Emmanouil T. Dermitzakis, Tim D. Spector, Genevieve Lachance, Yansheng Liu, Olga Vitek, Ludovic C Gillet, Lorenz C. Blum
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, 11 (2)
Liu, Y, Buil, A, Collins, B C, Gillet, L CJ, Blum, L C, Cheng, L-Y, Vitek, O, Mouritsen, J, Lachance, G, Spector, T D, Dermitzakis, E T & Aebersold, R 2015, ' Quantitative variability of 342 plasma proteins in a human twin population ', Molecular systems biology, vol. 11, no. 2, 786 . https://doi.org/10.15252/msb.20145728
Molecular Systems Biology, Vol. 11, No 1 (2015) P. 786
Molecular Systems Biology, 11 (2)
Liu, Y, Buil, A, Collins, B C, Gillet, L CJ, Blum, L C, Cheng, L-Y, Vitek, O, Mouritsen, J, Lachance, G, Spector, T D, Dermitzakis, E T & Aebersold, R 2015, ' Quantitative variability of 342 plasma proteins in a human twin population ', Molecular systems biology, vol. 11, no. 2, 786 . https://doi.org/10.15252/msb.20145728
Molecular Systems Biology, Vol. 11, No 1 (2015) P. 786
The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd58a3a6ec3294b1d6b6e44f11b6b1fe
http://europepmc.org/articles/PMC4358658
http://europepmc.org/articles/PMC4358658
Publikováno v:
Journal of the American Society for Mass Spectrometry, 24 (2)
Nyakas, Adrien; Blum, Lorenz C.; Stucki, Silvan R.; Reymond, Jean-Louis; Schürch, Stefan (2013). OMA and OPA—Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Journal of the American Society for Mass Spectrometry, 24(2), pp. 249-256. Springer-Verlag 10.1007/s13361-012-0529-1
J. Am. Soc. Mass Spectrom.
Nyakas, Adrien; Blum, Lorenz C.; Stucki, Silvan R.; Reymond, Jean-Louis; Schürch, Stefan (2013). OMA and OPA—Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Journal of the American Society for Mass Spectrometry, 24(2), pp. 249-256. Springer-Verlag 10.1007/s13361-012-0529-1
J. Am. Soc. Mass Spectrom.
The platform-independent software package consisting of the oligonucleotide mass assembler (OMA) and the oligonucleotide peak analyzer (OPA) was created to support the analysis of oligonucleotide mass spectra. It calculates all theoretically possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e075f68444e4ff4b39e342ec7027189
https://hdl.handle.net/20.500.11850/64621
https://hdl.handle.net/20.500.11850/64621
Publikováno v:
Journal of chemical information and modeling. 52(11)
Drug, molecules consist of a few tens of atoms connected by covalent bonds. Haw many such molecules are possible in total and what is their structure? This question is of pressing interest in: medicinal. chemistry to help solve the problems of drug p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7784201afa1c09743dd20e2fcf6ed72d
https://pubmed.ncbi.nlm.nih.gov/23088335
https://pubmed.ncbi.nlm.nih.gov/23088335