Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lorenz, Siebenbürger"'
Autor:
Christian Schütz, Duy‐Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Röhrig, Christian Herr, Andreas Martin Kany, Katharina Rox, Stefan Schmelz, Lorenz Siebenbürger, Marius Wirth, Carsten Börger, Samir Yahiaoui, Robert Bals, Andrea Scrima, Wulf Blankenfeldt, Justus Constantin Horstmann, Rebekka Christmann, Xabier Murgia, Marcus Koch, Aylin Berwanger, Brigitta Loretz, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Claus‐Michael Lehr, Martin Empting
Publikováno v:
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Abstract Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional
Externí odkaz:
https://doaj.org/article/e48e16d2f7b2409bac151ac65a104396
Cystobactamid 507: Concise Synthesis, Mode of Action and Optimization toward More Potent Antibiotics
Autor:
Rolf Müller, Rolf W. Hartmann, Mostafa M. Hamed, Jana Krull, Lorenz Siebenbürger, Sascha Baumann, Katarina Cirnski, Andreas Kirschning, Mark Brönstrup, Walid A. M. Elgaher, Jennifer Herrmann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
Germany
Chemistry (Weinheim an Der Bergstrasse, Germany)
Germany
Lack of new antibiotics and increasing antimicrobial resistance are among the main concerns of healthcare communities nowadays, and these concerns necessitate the search for novel antibacterial agents. Recently, we discovered the cystobactamids—a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea8580c05947bbdd3fb0af2eabbf48c
https://hdl.handle.net/10033/622128
https://hdl.handle.net/10033/622128
Autor:
Marius Hittinger, Xabier Murgia, Katherina Sewald, Claus-Michael Lehr, Konrad Schwarzkopf, Laura Müller, Susanne Häussler, Lorenz Siebenbürger, Armin Braun, Carsten Börger, Sabine Wronski
Publikováno v:
The Journal of antimicrobial chemotherapy
England
England
Objectives In the context of cystic fibrosis, Pseudomonas aeruginosa biofilms often develop in the vicinity of airway mucus, which acts as a protective physical barrier to inhaled matter. However, mucus can also adsorb small drug molecules administer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7523ebcfe25639de84e60db0166d118b
https://doi.org/10.1093/jac/dky241
https://doi.org/10.1093/jac/dky241
Autor:
Emmanuel Bey, Chris J. van Koppen, Matthias W. Laschke, Mohamed Salah, Carsten Börger, Martin Frotscher, Ahmed S. Abdelsamie, Lorenz Siebenbürger, Michael D. Menger
Publikováno v:
European Journal of Medicinal Chemistry. 127:944-957
Current endocrine therapeutics for the estrogen-dependent disease endometriosis often lead to considerable side-effects as they act by reducing estrogen action systemically. A more recent approach takes advantage of the fact that the weak estrogen es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681b60c43a98312f9761a0d03b45cfb3
https://doi.org/10.1016/j.ejmech.2016.11.004
https://doi.org/10.1016/j.ejmech.2016.11.004
Autor:
Martin Frotscher, Ahmed S. Abdelsamie, Rolf W. Hartmann, Sebastian Müller, Sandrine Marchais-Oberwinkler, Chris J. van Koppen, Matthias W. Laschke, Lorenz Siebenbürger, Mohamed Salah, Ahmed Merabet, Claudia Scheuer, Oliver Zierau, Michael D. Menger, Günter Vollmer
Publikováno v:
Journal of medicinal chemistry. 62(15)
Osteoporosis is predominantly treated with drugs that inhibit further bone resorption due to estrogen deficiency. Yet, osteoporosis drugs that not only inhibit bone resorption but also stimulate bone formation, such as potentially inhibitors of 17β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab02369095497d2b4ea68f6ffabf214
https://pubmed.ncbi.nlm.nih.gov/31343176
https://pubmed.ncbi.nlm.nih.gov/31343176
Autor:
Carsten Börger, Mostafa M. Hamed, Martin Frotscher, Lorenz Siebenbürger, Mohamed Salah, Ahmed S. Abdelsamie, Rolf W. Hartmann, Chris J. van Koppen
Publikováno v:
European journal of medicinal chemistry. 178
Estrogens are the major female sex steroid hormones, estradiol (E2) being the most potent form in humans. Disturbing the balance between E2 and its weakly active oxidized form estrone (E1) leads to diverse types of estrogen-dependent diseases such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edde835d25a608921fa3e010d34f01f
https://pubmed.ncbi.nlm.nih.gov/31176098
https://pubmed.ncbi.nlm.nih.gov/31176098
Autor:
Michael D. Menger, Martin Frotscher, Lorenz Siebenbürger, Matthias W. Laschke, Rolf W. Hartmann, Carsten Börger, Steven C. Herath, Mohamed Salah, Yannik Biskupek, Tim Pohlemann, Ahmed S. Abdelsamie, Claudia Scheuer, Sandrine Marchais-Oberwinkler, Chris J. van Koppen
Publikováno v:
Journal of medicinal chemistry. 62(3)
Current therapies of steroid hormone-dependent diseases predominantly alter steroid hormone concentrations (or their actions) in plasma, in target and nontarget tissues alike, rather than in target organs only. Targeted therapy through the inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936062b4a4834811593a989e57dd5b07
https://pubmed.ncbi.nlm.nih.gov/30645111
https://pubmed.ncbi.nlm.nih.gov/30645111
Autor:
Teresa Röhrig, Marcus Koch, Lorenz Siebenbürger, Carsten Börger, Claus-Michael Lehr, Rolf W. Hartmann, Mostafa M. Hamed, Wulf Blankenfeldt, Robert Bals, Stefan Schmelz, Andrea Scrima, Duy-Khiet Ho, Christian Herr, Brigitta Loretz, Samir Yahiaoui, Justus C Horstmann, Andreas M. Kany, Christian Schütz, Martin Empting, Katharina Rox, Xabier Murgia, Rebekka Christmann, Ahmed S. Abdelsamie, Anna K. H. Hirsch, Marius Wirth, Aylin Berwanger
Publikováno v:
Adv Sci (Weinh)
In article number 2004369, Martin Empting and colleagues describe a new generation of dual‐loaded nanoparticles enabling efficient eradication of Pseudomonas aeruginosa biofilms. The squalene‐based nanocarrier facilitates co‐delivery of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19e4c719c8d14b88b49fe47cd43a07c
https://doi.org/10.1002/advs.202170069
https://doi.org/10.1002/advs.202170069
Autor:
Robert Bals, Andrea Scrima, Christian Herr, Marius Wirth, Xabier Murgia, Teresa Röhrig, Marcus Koch, Justus C Horstmann, Andreas M. Kany, Mostafa M. Hamed, Stefan Schmelz, Claus-Michael Lehr, Ahmed S. Abdelsamie, Duy-Khiet Ho, Christian Schütz, Anna K. H. Hirsch, Samir Yahiaoui, Aylin Berwanger, Rebekka Christmann, Lorenz Siebenbürger, Wulf Blankenfeldt, Katharina Rox, Brigitta Loretz, Rolf W. Hartmann, Carsten Börger, Martin Empting
Publikováno v:
Advanced Science
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)
Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aafcb711c0f8031547c018d1203b94f
https://doi.org/10.1002/advs.202004369
https://doi.org/10.1002/advs.202004369
Autor:
Rolf W. Hartmann, Jennifer Herrmann, Sascha Baumann, Mark Brönstrup, Mostafa M. Hamed, Walid A. M. Elgaher, Jana Krull, Lorenz Siebenbürger, Katarina Cirnski, Andreas Kirschning, Rolf Müller
Publikováno v:
Chemistry – A European Journal. 26:7141-7141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a3c8b76ccbdc68b6b3ce9ac063d078
https://doi.org/10.1002/chem.202002127
https://doi.org/10.1002/chem.202002127