Výsledky vyhledávání - "Lorena del Pozo-Acebo"

Akademický článek

Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous miRNAs

Autor: María-Carmen López de las Hazas, Joao Tomé-Carneiro, Lorena del Pozo-Acebo, Andrea del Saz-Lara, Luis A. Chapado, Livia Balaguer, Enrique Rojo, Juan Carlos Espín, Carmen Crespo, Diego A. Moreno, Cristina García-Viguera, José M. Ordovás, Francesco Visioli, Alberto Dávalos

Publikováno v: Pharmacological Research, Vol 198, Iss , Pp 106999- (2023)

Cell-to-cell communication strategies include extracellular vesicles (EVs) in plants and animals. The bioactive molecules in a diet rich in vegetables and fruits are associated with disease-preventive effects. Plant-derived EVs (PDEVs) are biogenetic

Externí odkaz: https://doaj.org/article/5d333e40a2bc4921ac03a35fab16f939

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Connection between miRNA Mediation and the Bioactive Effects of Broccoli (Brassica oleracea var. italica): Exogenous miRNA Resistance to Food Processing and GI Digestion

Autor: M. Carmen Crespo, Andrea del Saz, Wilza Arantes Ferreira Peres, Alberto Dávalos, Lorena Del Pozo-Acebo, Joao Tomé-Carneiro, Luis A. Chapado, María Belén Ruiz-Roso, Roberto Martín-Hernández, Silvia Hernández de la Red, María-Carmen López de Las Hazas, Judit Gil-Zamorano, Gema de la Peña

Publikováno v: Journal of Agricultural and Food Chemistry. 69:9326-9337

Broccoli (Brassica oleracea var. italica) and its bioactive compounds are associated with beneficial health effects, which might be enabled, at least in part, through miRNA regulation, despite recent controversial studies suggesting that exogenous di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f52632fe2583e2dc3cc8d8b6eea02edd
https://doi.org/10.1021/acs.jafc.1c04087

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Therapeutic potential of broccoli-derived extracellular vesicles as nanocarriers of exogenous miRNAs

Autor: Lorena del Pozo-Acebo, María-Carmen López de las Hazas, Joao Tomé-Carneiro, Andrea del Saz-Lara, Judit Gil-Zamorano, Livia Balaguer, Luis A. Chapado, Rebeca Busto, Francesco Visioli, Alberto Dávalos

Publikováno v: Pharmacological research. 185

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression. The wide-ranging biological activities of microRNAs stimulated research on disease mechanisms and is suggesting appealing therapeutic applications. When unprotected, miRNAs su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7de09f1ae882d06d5a06d8a92d80a6
https://pubmed.ncbi.nlm.nih.gov/36182038

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Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression

Autor: Maria Hansen, Diana C. Mantilla-Escalante, Diego Gómez-Coronado, María-Carmen López de Las Hazas, Jan T. Rasmussen, Almudena García-Ruiz, Lorena Del Pozo-Acebo, Judit Gil-Zamorano, Alberto Dávalos, Francisco R. Marín

Publikováno v: European journal of nutrition. 61(2)

Extracellular RNAs are unstable and rapidly degraded unless protected. Bovine-milk extracellular vesicles (EVs) confer protection to dietary miRNAs, although it remains unclear whether this importantly improves their chances of reaching host target c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfa157f0b5df2ac1e5bee3335edc37c
https://pubmed.ncbi.nlm.nih.gov/35192027

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Eating microRNAs: pharmacological opportunities for cross-kingdom regulation and implications in host gene and gut microbiota modulation

Autor: Alberto Dávalos, Abelardo Margolles, Almudena García-Ruiz, María-Carmen López de Las Hazas, Lorena Del Pozo-Acebo

Publikováno v: British journal of pharmacologyREFERENCES. 178(11)

Cross-kingdom communication via non-coding RNAs is a recent discovery. Exogenous microRNAs (exog-miRNAs) mainly enter the host via the diet. Generally considered unstable in the gastrointestinal tract, some exogenous RNAs may resist these conditions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dca39d108c8ea6761fbbf0f33cfa21d
https://pubmed.ncbi.nlm.nih.gov/33644849

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Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy

Autor: Alberto Dávalos, Rodrigo San-Cristobal, Joao Tomé-Carneiro, Almudena García-Ruiz, Lorena Del Pozo-Acebo, María-Carmen López de Las Hazas, Rebeca Busto, Paula Gil-Cabrerizo

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 1105, p 1105 (2021)
Volume 22
Issue 3

MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene expression in crucial biological processes, which converts them into high potential contenders in the ongoing search for effective therapeutic strategies. However, ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe66b470095ae52727d27283f7a9687
https://pubmed.ncbi.nlm.nih.gov/33499350

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Mediterranean diet enriched in extra-virgin olive oil or nuts modulates circulating exosomal non-coding RNAs

Autor: Joao Tomé-Carneiro, María-Carmen López de Las Hazas, M. Carmen Crespo, Roberto Martín-Hernández, Diana C. Mantilla-Escalante, Lorena Del Pozo-Acebo, Alberto Dávalos, Mònica Bulló, Jordi Salas-Salvadó

Publikováno v: European journal of nutrition. 60(8)

Exosomes are extracellular vesicles secreted by cells, which can transport different molecules, including nucleic acids. Dietary habits may induce gene regulation through the modulation of exosomal RNAs. We aimed at characterizing exosomal lncRNAs, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3ceb7c475f3b073d0548b189a96478
https://pubmed.ncbi.nlm.nih.gov/34027583

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Intestinal miRNAs regulated in response to dietary lipids

Autor: Diego Gómez-Coronado, Mónica Castro-Camarero, Joao Tomé-Carneiro, M. Carmen Crespo, María-Jesús Latasa, Olivier Briand, Lorena Del Pozo-Acebo, Luis A. Chapado, Emilio Herrera, Alberto Dávalos, María Belén Ruiz-Roso, Judit Gil-Zamorano, María-Carmen López de Las Hazas

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports

The role of miRNAs in intestinal lipid metabolism is poorly described. The small intestine is constantly exposed to high amounts of dietary lipids, and it is under conditions of stress that the functions of miRNAs become especially pronounced. Approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0619c38c7cf5c467d2ce9d3e860f13a
https://doi.org/10.1038/s41598-020-75751-w

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