Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Lorena Varela‐Nallar"'
Autor:
Bastian Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo C. Meza, Nicolas Merino-Veliz, Gino Nardocci, Lorena Varela-Nallar, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Autism spectrum disorders (ASD) are complex neurodevelopmental conditions characterized by impairments in social communication, repetitive behaviors, and restricted interests. Epigenetic modifications serve as critical regulators of gene exp
Externí odkaz:
https://doaj.org/article/14a9f71f10044803956e81a9520de0f0
Autor:
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Brigitte van Zundert
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FT
Externí odkaz:
https://doaj.org/article/70b04753b9844b6f898175dad9993d01
Autor:
Sebastian B. Arredondo, Daniel T. Reyes, Andrea Herrera-Soto, Muriel D. Mardones, Nibaldo C. Inestrosa, Lorena Varela-Nallar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate, induces
Externí odkaz:
https://doaj.org/article/ca4b966c21c9405888f78dead9baf1c9
Autor:
Eva Ramos-Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela-Nallar, Nibaldo C. Inestrosa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO). Trying
Externí odkaz:
https://doaj.org/article/390ac201791347b586eeab76239c7001
Autor:
Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G. Guerrero, Fabian Segovia-Miranda, David M. Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar, Alfonso González
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated
Externí odkaz:
https://doaj.org/article/706d6d1a38ce4746a112602d79945e18
Autor:
Miguel V. Guerra, Matías I. Cáceres, Andrea Herrera-Soto, Sebastián B. Arredondo, Manuel Varas-Godoy, Brigitte van Zundert, Lorena Varela-Nallar
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
In the dentate gyrus of the adult hippocampus new neurons are generated from neural precursor cells through different stages including proliferation and differentiation of neural progenitor cells and maturation of newborn neurons. These stages are co
Externí odkaz:
https://doaj.org/article/62de9ae5e0b1424193784b28f2923b97
Autor:
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela-Nallar
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dent
Externí odkaz:
https://doaj.org/article/64293ae60d764ac59effa6232ee3b4f3
Autor:
Lorena Varela-Nallar, Sebastian B. Arredondo, Cheril Tapia-Rojas, Juan Hancke, Nibaldo C. Inestrosa
Publikováno v:
Neural Plasticity, Vol 2015 (2015)
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), a key
Externí odkaz:
https://doaj.org/article/1d48c9dc7c75488485ffe526985498a3
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 39-44 (2006)
Prion diseases are fatal neurodegenerative disorders associated with the conversion of the cellular prion protein (PrPC) into a pathologic isoform. Although the physiological function of PrPC remains unknown, evidence relates PrPC to copper metabolis
Externí odkaz:
https://doaj.org/article/4ea79e098f4a4831b05d34696ac89af5
Autor:
Fernando J Bustos, Lorena Varela-Nallar, Matias Campos, Berta Henriquez, Marnie Phillips, Carlos Opazo, Luis G Aguayo, Martin Montecino, Martha Constantine-Paton, Nibaldo C Inestrosa, Brigitte van Zundert
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94037 (2014)
Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear. Here we investigate the rol
Externí odkaz:
https://doaj.org/article/51288436b9df4ac6a4cf47d40c73b7ba