Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lorena Taboada"'
Autor:
Mark G. Bures, David Edward Tupper, Joan H. Carter, James A. Monn, David L. McKinzie, Marijane Russell, Lourdes Prieto, Steven S. Henry, Reinhard Matthew Robert, Alicia Marcos, Lesley Walton, Christopher David Beadle, Bryan G. Johnson, Brian G. Getman, John T. Catlow, Frances Lu, Xushan Wang, Lorena Taboada, S. Richard Baker, Beverly A. Heinz, Helene Rudyk, David B. Shaw, Jaime Blanco, Carlos Lamas, Steven Swanson, David K. Clawson, Junliang Hao, Carlos Montero, Teresa Man, Shane Atwell, Barry Peter Clark, Jing Wang
Publikováno v:
Journal of Medicinal Chemistry. 58:7526-7548
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Autor:
Junliang Hao, Matt R. Reinhard, Barry Peter Clark, Jaime Blanco, Concepción Pedregal, Shane Atwell, Michael P. Johnson, Paul Goldsmith, Carlos Montero, Rosa Maria A. Simmons, James A. Monn, Steven Swanson, Chuanxi Xiang, Bryan G. Johnson, Frances Lu, Lorena Taboada, Teresa Man, David K. Clawson, Marijane Russell, Lesley Walton, Steven S. Henry, Jing Wang, Beverly A. Heinz, S. Richard Baker, Helen E. Sanger, Xushan Wang, David B. Shaw, Lourdes Prieto, Mark G. Bures, Joan H. Carter, Lisa M. Broad, Kelly L. Knopp, Helene Rudyk, David L. McKinzie, David Edward Tupper, Christopher David Beadle, John T. Catlow, Carlos Lamas, Alicia Marcos
Publikováno v:
Journal of Medicinal Chemistry. 58:1776-1794
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Autor:
Gary Gilmour, Dale M. Edgar, Francois Gastambide, Lorena Taboada, Beverly A. Heinz, Elaine Shanks, Brian G. Getman, Lourdes Prieto, Janice W. Smith, Lisa M. Broad, Thomas C. Britton, Keith A. Wafford, Adam M. Fivush, Mark D. Tricklebank, Andrew McCarthy, Ellen M. Colvin
Publikováno v:
Neuropharmacology. 64:224-239
The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Developmen
Autor:
Bernat Vidal, Lorena Taboada, MA López, Cristina Esteve, Pilar Forns, Montserrat Miralpeix, J. A. Alonso, Isabel Ramis, Adelina Orellana, Cristina Carreño, M. I. Maldonado
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2784-2788
A series of aminopyrazines as inhibitors of Syk kinase activity and showing inhibition of LAD2 cells degranulation is described. Optimization of the carboxamide motif with aminomethylpiperidines provided high potency inhibiting Syk but low cellular a
Autor:
James A, Monn, Lourdes, Prieto, Lorena, Taboada, Junliang, Hao, Matthew R, Reinhard, Steven S, Henry, Christopher D, Beadle, Lesley, Walton, Teresa, Man, Helene, Rudyk, Barry, Clark, David, Tupper, S Richard, Baker, Carlos, Lamas, Carlos, Montero, Alicia, Marcos, Jaime, Blanco, Mark, Bures, David K, Clawson, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xushan, Wang, Joan H, Carter, Brian G, Getman, John T, Catlow, Steven, Swanson, Bryan G, Johnson, David B, Shaw, David L, McKinzie
Publikováno v:
Journal of medicinal chemistry. 58(18)
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Autor:
James A, Monn, Lourdes, Prieto, Lorena, Taboada, Concepcion, Pedregal, Junliang, Hao, Matt R, Reinhard, Steven S, Henry, Paul J, Goldsmith, Christopher D, Beadle, Lesley, Walton, Teresa, Man, Helene, Rudyk, Barry, Clark, David, Tupper, S Richard, Baker, Carlos, Lamas, Carlos, Montero, Alicia, Marcos, Jaime, Blanco, Mark, Bures, David K, Clawson, Shane, Atwell, Frances, Lu, Jing, Wang, Marijane, Russell, Beverly A, Heinz, Xushan, Wang, Joan H, Carter, Chuanxi, Xiang, John T, Catlow, Steven, Swanson, Helen, Sanger, Lisa M, Broad, Michael P, Johnson, Kelly L, Knopp, Rosa M A, Simmons, Bryan G, Johnson, David B, Shaw, David L, McKinzie
Publikováno v:
Journal of medicinal chemistry. 58(4)
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Autor:
Gary, Gilmour, Lisa M, Broad, Keith A, Wafford, Thomas, Britton, Ellen M, Colvin, Adam, Fivush, Francois, Gastambide, Brian, Getman, Beverly A, Heinz, Andrew P, McCarthy, Lourdes, Prieto, Elaine, Shanks, Janice W, Smith, Lorena, Taboada, Dale M, Edgar, Mark D, Tricklebank
Publikováno v:
Neuropharmacology. 64
The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Developmen
Publikováno v:
Tetrahedron Letters. 42:1891-1893
The reduction of methionine sulfoxide with Bu4NBr in TFA is reported. The use of this reagent in conjunction with Fmoc chemistry-based acidolytic cocktails and the short reaction times that are needed for sulfoxide reduction (5 min) are the main adva
Publikováno v:
Journal of the American Chemical Society. 127(50)
The study of dividing objects into isometric segments has yielded novel approaches to the synthesis of high-symmetry organic compounds. Reported herein is the first application of this concept to a protein, rabbit uteroglobin (UG). Bisection of UG in
Publikováno v:
Journal of Combinatorial Chemistry. Sep2007, Vol. 9 Issue 5, p748-755. 8p.