Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lorena Simon-Gracia"'
Autor:
Luca Marchetti, Lorena Simon-Gracia, Chiara Lico, Mariateresa Mancuso, Selene Baschieri, Luca Santi, Tambet Teesalu
Publikováno v:
Nanomaterials, Vol 13, Iss 8, p 1428 (2023)
Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse nanocarriers that are biocompatible, biod
Externí odkaz:
https://doaj.org/article/18b33af02b3540639b975bf54f53debc
Autor:
Eric Savier, Lorena Simon-Gracia, Frederic Charlotte, Pierre Tuffery, Tambet Teesalu, Olivier Scatton, Angelita Rebollo
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1631 (2021)
Background: The interfering peptides that block protein–protein interactions have been receiving increasing attention as potential therapeutic tools. Methods: We measured the internalization and biological effect of four bi-functional tumor-penetra
Externí odkaz:
https://doaj.org/article/7defdd8c18624527a50a355652c6e56d
Autor:
Valeria Sidorenko, Pablo Scodeller, Ain Uustare, Ivan Ogibalov, Andrus Tasa, Olga Tshubrik, Liis Salumäe, Kazuki N. Sugahara, Lorena Simón-Gracia, Tambet Teesalu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Cancer treatment with vascular disrupting agents (VDAs) causes rapid and extensive necrosis in solid tumors. However, these agents fall short in eliminating all malignant cells, ultimately leading to tumor regrowth. Here, we investigated whe
Externí odkaz:
https://doaj.org/article/c2c0fe2679b5496d819101b030d83b28
Autor:
Denis Cecchin, Carla Pegoraro, Nicholas J. Warren, Lorena Simon Gracia, Steven P. Armes, Jeppe Madsen, Sheila MacNeil, Giuseppe Battaglia, Andrew Lewis
Publikováno v:
Cancer Letters
We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate that PMPC25-PDPA70 polymersomes can encapsulate doxorubici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f835090d205d20d98eab4faaa38b4090
https://pubmed.ncbi.nlm.nih.gov/23402813
https://pubmed.ncbi.nlm.nih.gov/23402813
Autor:
María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia, Marina Simian
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. With the aim of developi
Externí odkaz:
https://doaj.org/article/5ab1e1b4fce049219d0d2e9885a90591
Autor:
Lorena Simón-Gracia, Kristina Kiisholts, Vilma Petrikaitė, Allan Tobi, Merli Saare, Prakash Lingasamy, Maire Peters, Andres Salumets, Tambet Teesalu
Publikováno v:
Nanomaterials, Vol 11, Iss 12, p 3257 (2021)
The current diagnostic and therapeutic strategies for endometriosis are limited. Although endometriosis is a benign condition, some of its traits, such as increased cell invasion, migration, tissue inflammation, and angiogenesis are similar to cancer
Externí odkaz:
https://doaj.org/article/0ac65f2aa8064ed291a9a93f69582765
Autor:
Kai K. Ewert, Pablo Scodeller, Lorena Simón-Gracia, Victoria M. Steffes, Emily A. Wonder, Tambet Teesalu, Cyrus R. Safinya
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1365 (2021)
Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA (siRNA), have been pursued for decades to realize the promise of gene
Externí odkaz:
https://doaj.org/article/c26ac335137144e4b588566a107610d5
Autor:
Hideki Ikemoto, Prakash Lingasamy, Anne-Mari Anton Willmore, Hedi Hunt, Kaarel Kurm, Olav Tammik, Pablo Scodeller, Lorena Simón-Gracia, Venkata Ramana Kotamraju, Andrew M Lowy, Kazuki N Sugahara, Tambet Teesalu
Publikováno v:
Tumor Biology, Vol 39 (2017)
Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challeng
Externí odkaz:
https://doaj.org/article/b95d5ada078f4996a6118a209360f0d8
Publikováno v:
Molecules, Vol 23, Iss 5, p 1190 (2018)
Over recent decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies—a grim condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to ac
Externí odkaz:
https://doaj.org/article/f52bb84fe15b4e59b57b7e329a852404
Autor:
Peter Fransen, Daniel Pulido, Lorena Simón-Gracia, Ana Paula Candiota, Carles Arús, Fernando Albericio, Miriam Royo
Publikováno v:
Journal of Nanotechnology, Vol 2015 (2015)
In magnetic resonance imaging, contrast agents are employed to enhance the signal intensity. However, current commercial contrast agents are hindered by a low relaxivity constant. Dendrimers can be employed to create higher molecular weight contrast
Externí odkaz:
https://doaj.org/article/da365ff79fc84af286c457f3636f0f6b