Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Lorena S. Beese"'
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Fluorescent labeling of proteins is a powerful tool for probing structure-function relationships with many biosensing applications. Structure-based rules for systematically designing fluorescent biosensors require understanding ligand-mediat
Externí odkaz:
https://doaj.org/article/4ede28d421394daea94e2600cf48249d
Autor:
Niyo Kato, Yoshitaka Kawasoe, Hannah Williams, Elena Coates, Upasana Roy, Yuqian Shi, Lorena S. Beese, Orlando D. Schärer, Hong Yan, Max E. Gottesman, Tatsuro S. Takahashi, Jean Gautier
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1375-1385 (2017)
Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription
Externí odkaz:
https://doaj.org/article/e9515601f53a4fa7831ca182a70819ab
Publikováno v:
Nucleic Acids Research.
DNA polymerases are essential for nucleic acid synthesis, cloning, sequencing and molecular diagnostics technologies. Conditional intein splicing is a powerful tool for controlling enzyme reactions. We have engineered a thermal switch into thermostab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d00be0b4fe607c91f6a2ed0432655e6
https://doi.org/10.1093/nar/gkad368
https://doi.org/10.1093/nar/gkad368
Autor:
You Wang, Feng Xu, Connie B. Nichols, Yuqian Shi, Homme W. Hellinga, J. Andrew Alspaugh, Mark D. Distefano, Lorena S. Beese
Publikováno v:
Journal of medicinal chemistry. 65(20)
Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently. We have developed compounds that prevent farnesylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d9a22577ce09ce6f157a9c9f1a6793
https://pubmed.ncbi.nlm.nih.gov/36218371
https://pubmed.ncbi.nlm.nih.gov/36218371
Autor:
Kimberly T. Lane, Lorena S. Beese
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 4, Pp 681-699 (2006)
More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation). Prenylated proteins include members of the Ras, Rab,
Externí odkaz:
https://doaj.org/article/b81207d7b6b54ca9a8cd61fdd9ae6022
High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of single-stranded DNA bound to the 3'-5' exonuclease act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6a4d436291c2496dd23b430b168fa6
https://doi.org/10.1142/9789811215865_0024
https://doi.org/10.1142/9789811215865_0024
Publikováno v:
Proceedings of the National Academy of Sciences. 114:6010-6015
Human exonuclease 1 (hExo1) is a member of the RAD2/XPG structure-specific 5'-nuclease superfamily. Its dominant, processive 5'-3' exonuclease and secondary 5'-flap endonuclease activities participate in various DNA repair, recombination, and replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0f59cc423ecd87e3e9f1c086d62580
https://doi.org/10.1073/pnas.1704845114
https://doi.org/10.1073/pnas.1704845114
Autor:
Yoshitaka Kawasoe, Jean Gautier, Lorena S. Beese, Elena Lauren Coates, Orlando D. Schärer, Hannah Williams, Maxwell E. Gottesman, Yuqian Shi, Niyo Kato, Tatsuro S. Takahashi, Upasana Roy, Hong Yan
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1375-1385 (2017)
Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87161a831a9f678f93660d79312af353
https://europepmc.org/articles/PMC5806701/
https://europepmc.org/articles/PMC5806701/