Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lorena Riol Blanco"'
Autor:
Min Jung, Michelle Dourado, James Maksymetz, Amanda Jacobson, Benjamin I. Laufer, Miriam Baca, Oded Foreman, David H. Hackos, Lorena Riol-Blanco, Joshua S. Kaminker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Sensory neurons are critical for maintaining tissue homeostasis. Here, the authors generated a single-nuclei cross-species atlas of the dorsal root ganglia, revealing conserved programs for sensory function that could inform therapeutic hypotheses.
Externí odkaz:
https://doaj.org/article/45364aef1d7b4294b20a95c973a19812
Autor:
Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La
Publikováno v:
Journal of Medicinal Chemistry. 64:3843-3869
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023
https://doi.org/10.1021/acs.jmedchem.0c02023
Autor:
Søren Warming, Lorena Riol-Blanco, Shannon D. Shields, Wyne P. Lee, David H. Hackos, Michelle Dourado, Keith R. Anderson, Rebecca M. Reese, Alessia Balestrini, Kimberly L. Stark, Eric Suto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP channels showing high levels of expression in sensory neurons such as TRPV1, TRPA1, and TRPM8, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f8f5bf529a1f99b921b19ca00a4b27
http://link.springer.com/article/10.1038/s41598-020-57936-5
http://link.springer.com/article/10.1038/s41598-020-57936-5
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637
https://doi.org/10.1084/jem.20201637
Publikováno v:
Cell, 181(3), 517. Cell Press
Some children with autism spectrum disorder (ASD) show behavioral improvements when experiencing inflammation accompanied by fever; however, little is known about the mechanisms that underlie these beneficial effects. In a recent issue of Nature, Ree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a9bbc6237bb03e8c651c014cfd3302
https://dspace.library.uu.nl/handle/1874/409832
https://dspace.library.uu.nl/handle/1874/409832
Autor:
Alexander R. Abbas, Brian L. Yaspan, Fang Cai, Jens Reeder, John G. Matthews, David F. Choy, Joseph Lin, Diana Chang, Bill Forrest, Tracy Staton, Art Wuster, Timothy W. Behrens, Cecile T.J. Holweg, Kiran Mukhyala, Tangsheng Yi, Lorena Riol Blanco, Tushar Bhangale, Matt Brauer, Rajita Pappu, Daniel Lafkas, Amy Cowgill, Julie Olsson, Joseph R. Arron, Amy Dressen, Hubert Chen, Julie Hunkapiller, Karen Cuenco, Dorothy Cheung, Jennifer Tom, Robert R. Graham, Zia Khan, Mark S. Wilson, Rebecca N. Bauer, Jan Vogel
Publikováno v:
Genes and environment.
Introduction: Genome-wide association studies (GWAS) have discovered >30 loci associated with asthma risk. Despite the characterization of asthma as a heterogeneous disorder, most GWAS evaluate asthmatics as a single population. To explore whether ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::085d86fd2e25be637fd303f884b69d93
https://doi.org/10.1183/13993003.congress-2018.oa2194
https://doi.org/10.1183/13993003.congress-2018.oa2194
Autor:
Lorena Riol-Blanco, Nazila Kamaly, Jun Wu, Sangyong Jon, Mi Kyung Yu, Ulrich H. von Andrian, Ira Tabas, In Hyun Lee, Archana Swami, Jinjun Shi, Won Il Choi, Basit Yameen, Omid C. Farokhzad, Cristian Vilos
Publikováno v:
Nano Letters
Technical University of Denmark Orbit
Technical University of Denmark Orbit
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cd462f849466b2efe87529aef4b025
http://europepmc.org/articles/PMC4245989
http://europepmc.org/articles/PMC4245989
Autor:
Brent S. McKenzie, Eric Suto, Lawren C. Wu, Ivan Peng, Jeffrey Eastham-Anderson, Connie Chan, Lorena Riol-Blanco, Kate Senger, Ali A. Zarrin, Tracy Staton, Janet Jackman, Justin Lesch, Allan Jaochico, Surinder Jeet, Nico Ghilardi, Jason DeVoss, Joshua D. Webster, Joseph R. Arron, Hai Ngu, Jason Burch, Yonglian Sun, Kathy Barrett, Charles Havnar, Yuan Chen, Zhonghua Pei, Cary D. Austin, Jenna L. Collier, Olga Li, George Francis, Meijuan Zhou, Wyne P. Lee, David F. Choy, Xiumin Wu, Moulay Hicham Alaoui Ismaili
Publikováno v:
Science Signaling. 8
Interleukin-2 (IL-2)-inducible T cell kinase (ITK) mediates T cell receptor (TCR) signaling primarily to stimulate the production of cytokines, such as IL-4, IL-5, and IL-13, from T helper 2 (TH2) cells. Compared to wild-type mice, ITK knockout mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7056f2713b1883d81b6f5ffac8f941c1
https://doi.org/10.1126/scisignal.aab0949
https://doi.org/10.1126/scisignal.aab0949
Autor:
Paloma Sánchez-Mateos, María Rodríguez-Martínez, Lucía Sánchez-Ruiloba, José Luis Rodríguez-Fernández, Miguel R. Campanero, Roberto Martín Jean-Mairet, Sandra Sacristán, Celia López-Menéndez, Francisco Sánchez-Madrid, Lorena Riol-Blanco, Teresa Iglesias
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
12 páginas, 7 figuras.-- et al.
Kinase D interacting substrate of 220kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is a protein that is mainly expressed in brain and neural cells where its function is only startin
Kinase D interacting substrate of 220kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is a protein that is mainly expressed in brain and neural cells where its function is only startin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8930b99960a5a38b2fcd04f3a0c9bd
https://doi.org/10.1002/eji.201040513
https://doi.org/10.1002/eji.201040513
Autor:
Bernhard Hemmer, Lorena Riol Blanco, Vijay K. Kuchroo, Veit Rothhammer, Immo Prinz, Malte C. Claussen, Sylvia Heink, Jan D. Haas, Franziska Petermann, Thomas Korn, Mohamed Oukka
Publikováno v:
Immunity. 33(3):351-363
Summary Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of γδ T cells expresses the IL-23 receptor (IL-23R) constitutively. Using IL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9987cdcb19e0cea3e6135c0c6a04bd81