Cu(bta)(1,10-phen)ClO4 copper complex modulates the carcinogenicity of carboplatin in somatic cells of Drosophila melanogaster

Autor: Paula Marynella Alves Pereira Lima, Priscila Capelari Orsonlin, Nayane Moreira Machado, Rosiane Gomes Silva Oliveira, Lorena Polloni, Raquel Pereira Cruz, Janaína do Couto Almeida, Robson José de Oliveira Júnior, Wendell Guerra, Thaise Gonçalves Araújo

Publikováno v: Genetics and Molecular Biology, Vol 47, Iss 3 (2024)

Abstract Chemotherapy stands out as the main systemic treatment strategy against cancer and still faces problems related to multidrug resistance and severe side effects. Copper-based drugs have been widely explored in medicinal chemistry, since coppe

Externí odkaz: https://doaj.org/article/7596ba358ab84b0aa68758f53923bca8

A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA2-Asp-49 from Bothrops jararacussu Venom

Autor: Fernanda Van Petten de Vasconcelos Azevedo, Daiana Silva Lopes, Mariana Alves Pereira Zóia, Lucas Ian Veloso Correia, Natieli Saito, Belchiolina Beatriz Fonseca, Lorena Polloni, Samuel Cota Teixeira, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues Ávila

Publikováno v: Biomolecules, Vol 12, Iss 2, p 258 (2022)

Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living organisms, with a broad spectrum of pharmacological activities and therapeutic potential. Anti-angiogenic strategies have become one of the main tools in fightin

Externí odkaz: https://doaj.org/article/f1398483b1784a228e46457ca5a58c17

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death

Autor: Lorena Polloni, Ana Carolina de Seni Silva, Samuel Cota Teixeira, Fernanda Van Petten de Vasconcelos Azevedo, Mariana Alves Pereira Zóia, Marcelo Santos da Silva, Paula Marynella Alves Pereira Lima, Lucas Ian Veloso Correia, Janaina do Couto Almeida, Claudio Vieira da Silva, Veridiana de Melo Rodrigues Ávila, Luiz Ricardo Filho Goulart, Sandra Morelli, Wendell Guerra, Robson José de Oliveira Júnior

Publikováno v: Biomedicine & Pharmacotherapy, Vol 112, Iss , Pp - (2019)

This work reports the biological evaluation of a copper complex of the type [Cu(O–O)(N–N)ClO4], in which O–O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N–N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic e

Externí odkaz: https://doaj.org/article/14f13384d15e43d98acc5b392c6971f5

Biochemical characterization and assessment of leishmanicidal effects of a new L-amino acid oxidase from Crotalus durissus collilineatus snake venom (CollinLA AO-I)

Autor: Vitor de Freitas, Tássia Rafaella Costa, Amanda Rodrigues Nogueira, Lorena Polloni, Thales Alves de Melo Fernandes, Lucas Ian Veloso Correia, Bruna Cristina Borges, Samuel Cota Teixeira, Marcelo José Barbosa Silva, Fernanda Gobbi Amorim, Loïc Quinton, André Lopes Saraiva, Foued Salmen Espindola, Leo Kei Iwai, Renata Santos Rodrigues, Kelly Aparecida Geraldo Yoneyama, Veridiana de Melo Rodrigues Ávila

Publikováno v: Toxicon. 230:107156

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de95259c758dca8f4188291c5dcefbd
https://doi.org/10.1016/j.toxicon.2023.107156

DNA interactions, antitubercular and cytotoxic activity of heteroleptic Cu-II complexes containing 1,10-phenanthroline

Autor: Wendell Guerra, Raphael T. C Silva, Lorena Polloni, Janaina do Couto Almeida, Ana Maria da Costa Ferreira, Mariete Barbosa Moreira, Karyn Fernanda Manieri, Marcelo Cecconi Portes, Veridiana de Melo Rodrigues Ávila, Adelino Vieira de Godoy Netto, Fernanda Van Petten de Vasconcelos Azevedo, Gustavo Von Poelhsitz, Marcos Pivatto, Fernando Rogério Pavan, Renan D. Zanetti

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f5869407b68a16aa2ee7b5c3478b2d