Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lorena Martinez Gamboa"'
Publikováno v:
eLife, Vol 10 (2021)
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of
Externí odkaz:
https://doaj.org/article/1e36a8928c5749cab5a929648e5df906
Autor:
Vivian Oliveira Nunes Teixeira, Bárbara Jonson Bartikoski, Rafaela Cavalheiro do Espirito Santo, Paulo Vinícius Gil Alabarse, Khetam Ghannan, Jordana Miranda Souza Silva, Lidiane Isabel Filippin, Fernanda Visioli, Lorena Martinez-Gamboa, Eugen Feist, Ricardo Machado Xavier
Publikováno v:
Advances in Rheumatology, Vol 63, Iss 1, Pp 1-12 (2023)
Abstract Background Rheumatoid arthritis is an autoimmune inflammatory disease that often leads patients to muscle impairment and physical disability. This study aimed to evaluate changes in the activity of proteasome system in skeletal muscles of mi
Externí odkaz:
https://doaj.org/article/eb8e31c54a134de4a87ffe6ab567c7f9
Autor:
Natascha Ingrid Drude, Lorena Martinez-Gamboa, Meggie Danziger, Anja Collazo, Silke Kniffert, Janine Wiebach, Gustav Nilsonne, Frank Konietschke, Sophie K. Piper, Samuel Pawel, Charlotte Micheloud, Leonhard Held, Florian Frommlet, Daniel Segelcke, Esther M. Pogatzki-Zahn, Bernhard Voelkl, Tim Friede, Edgar Brunner, Astrid Dempfle, Bernhard Haller, Marie Juliane Jung, Lars Björn Riecken, Hans-Georg Kuhn, Matthias Tenbusch, Lina Maria Serna Higuita, Edmond J. Remarque, Servan Luciano Grüninger-Egli, Katrin Manske, Sebastian Kobold, Marion Rivalan, Lisa Wedekind, Juliane C. Wilcke, Anne-Laure Boulesteix, Marcus W. Meinhardt, Rainer Spanagel, Simone Hettmer, Irene von Lüttichau, Carla Regina, Ulrich Dirnagl, Ulf Toelch
Publikováno v:
Translational Medicine Communications, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinical evidence often lacks desired
Externí odkaz:
https://doaj.org/article/bf47b97f5e2949fb928a3da8d60cd224
Autor:
Natascha Drude, Lorena Martinez-Gamboa, Tamarinde Haven, Constance Holman, Martin Holst, Silke Kniffert, Sarah McCann, Torsten Rackoll, Robert Schulz, Sarah Weschke
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Increasing the reproducibility and trustworthiness of biomedical research requires engaging stakeholders from all levels in an institutional setting. The QUEST Center for Responsible Research aims to develop and implement new approaches to i
Externí odkaz:
https://doaj.org/article/635e6c052ea643a588bcfdb1446fb35f
Autor:
Pedro López-Romero, Lorena Martinez-Gamboa, Holger Bang, Inmaculada de la Torre, Thorsten Holzkämper, Eugen Feist
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Background The development of autoantibodies in patients with rheumatoid arthritis (RA) has potential as a marker of treatment response. This analysis assessed the association of an autoantibody response to carbamylated vimentin (anti-CarbV)
Externí odkaz:
https://doaj.org/article/a337b6a4d90d4f478c63c9c573fd7175
Autor:
Sarah Weschke, Sarah McCann, Torsten Rackoll, Martin Holst, Constance Holman, Robert Schulz, Tamarinde Haven, Silke Kniffert, Natascha Drude, Lorena Martinez-Gamboa
Publikováno v:
BMC Research Notes. 15
Increasing the reproducibility and trustworthiness of biomedical research requires engaging stakeholders from all levels in an institutional setting. The QUEST Center for Responsible Research aims to develop and implement new approaches to improve th
Background: Systematic reviews of health economic evaluations (SR-HEs) provide a critical tool for synthesizing published literature to guide decision makers towards implementing evidence-based policy and healthcare practice. However, the quality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5eb668a1e4e4fd7bb76aca5f38e131c
https://doi.org/10.21203/rs.3.rs-1653645/v1
https://doi.org/10.21203/rs.3.rs-1653645/v1
Autor:
Michael J. Parnham, Pascal Schendel, Marc Bonin-Andresen, Martine C J Hofmann, Anton Bespalov, Ulrich Dirnagl, Olga Arbach, Christoph H. Emmerich, Katja Hempel, Lorena Martinez Gamboa, Björn Gerlach
Publikováno v:
Nature Reviews. Drug Discovery
Academic research plays a key role in identifying new drug targets, including understanding target biology and links between targets and disease states. To lead to new drugs, however, research must progress from purely academic exploration to the ini
Publikováno v:
Aktuelle Rheumatologie. 46:465-473
Zusammenfassung Hintergrund TNF-α-Inhibitoren sind wirksame Medikamente bei vielen chronisch-inflammatorischen Erkrankungen. Trotz eines akzeptablen Wirkansprechens gibt es einen beachtlichen Anteil an Patienten, bei denen ein primärer oder sekund
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of