Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lorena Garcia Menendez"'
Autor:
Xiaoke Ma, Long Gao, Georgios Karamanlidis, Peng Gao, Chi Fung Lee, Lorena Garcia-Menendez, Rong Tian, Kai Tan
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004332 (2015)
Development of heart diseases is driven by dynamic changes in both the activity and connectivity of gene pathways. Understanding these dynamic events is critical for understanding pathogenic mechanisms and development of effective treatment. Currentl
Externí odkaz:
https://doaj.org/article/22eeffdb28b74fcfb47b6048d241c9a5
Las interacciones de estudiantes que poseen diferentes o similares niveles de conocimientos, mediados por la intervención docente, son una rica fuente de construcción o ampliación de conceptos. Las autoras sostienen que estas diferencias deben pot
Autor:
Marina T. DiStefano, Michael P. Czech, Joseph C. Yawe, Rachel J. Roth Flach, Lorena Garcia Menendez, Mark J. S. Kelly, Ozlem Senol-Cosar, Laura V. Danai
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 313:E303-E313
The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus metabolic function. The lymphatic vasculature regulates fluid and lipid homeostasis, and impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9e6ce5a22ec3952c57aa299293689c
https://doi.org/10.1152/ajpendo.00037.2017
https://doi.org/10.1152/ajpendo.00037.2017
Autor:
Michael P. Czech, Laura V. Danai, Rita Bortell, Lorena Garcia Menendez, Marina T. DiStefano, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rachel J. Roth Flach, Mark J. S. Kelly, Agata Jurczyk, Rohit Sharma, Laura C. Alonso
Publikováno v:
The Journal of Biological Chemistry
Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose toler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d776f28ab8a93f90c55e3824bafea0
http://europepmc.org/articles/PMC4965570
http://europepmc.org/articles/PMC4965570
Autor:
Joseph V. Virbasius, Dae Young Jung, Jason K. Kim, Michael P. Czech, Jong Hun Kim, Rachel J. Roth Flach, Lorena Garcia Menendez, Laura V. Danai
Publikováno v:
Molecular and Cellular Biology. 35:2356-2365
Studies in vitro suggest that mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) attenuates insulin signaling, but confirmation in vivo is lacking since Map4k4 knockout is lethal during embryogenesis. We thus generated mice with floxed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c03c4d0aa4c6e65d4cb6845c211db7
https://doi.org/10.1128/mcb.00150-15
https://doi.org/10.1128/mcb.00150-15
Autor:
Pranitha Vangala, Karen Gallagher-Dorval, Sarah M. Nicoloro, Yuefei Shen, Joseph C. Yawe, Jessica Cohen, Richard A. Perugini, Michaela Tencerova, Olga T. Gupta, David J. Pedersen, Lorena Garcia-Menendez, Michael P. Czech, Myriam Aouadi
Publikováno v:
The FASEB Journal. 29:2959-2969
Obesity promotes insulin resistance associated with liver inflammation, elevated glucose production, and type 2 diabetes. Although insulin resistance is attenuated in genetic mouse models that suppress systemic inflammation, it is not clear whether l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c158a9c64f6ccf893056e8a7c0ab2dc
https://doi.org/10.1096/fj.15-270496
https://doi.org/10.1096/fj.15-270496
Autor:
Wang Wang, Kei Sakamoto, Rong Tian, Jason Xu, Roger W. Hunter, Yu Ying Yang, Guohua Gong, Stephen C. Kolwicz, Lorena Garcia-Menendez, Maengjo Kim
Publikováno v:
Circulation Research. 114:966-975
Rationale: AMP-activated protein kinase is a master regulator of cell metabolism and an attractive drug target for cancer and metabolic and cardiovascular diseases. Point mutations in the regulatory γ2-subunit of AMP-activated protein kinase (encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc82d4046ee1de912e552fdbda86fc7c
https://doi.org/10.1161/circresaha.114.302364
https://doi.org/10.1161/circresaha.114.302364
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H397-H402
The C57BL/6 mouse strain is one of the most commonly used in experimental research. It is known to differ from other strains in baseline cardiovascular phenotypes as well as in response to pressure overload induced by aortic constriction. Since the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed58c103836c963388aa1233d279051
https://doi.org/10.1152/ajpheart.00088.2013
https://doi.org/10.1152/ajpheart.00088.2013
Autor:
Lorena Garcia-Menendez, Young Ah Goo, Nathan D. Roe, John Scott Edgar, David R. Goodlett, Juan D. Chavez, James E. Bruce, Ying Ann Chiao, Yong Seon Choi, Rong Tian, Chi Fung Lee
Background: Impairments of mitochondrial function in the heart are linked intricately to the development of heart failure, but there is no therapy for mitochondrial dysfunction. Methods: We assessed the reduced/oxidized ratio of nicotinamide adenine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45cea5902b359e5b6ae728434a35848
https://europepmc.org/articles/PMC5193133/
https://europepmc.org/articles/PMC5193133/
Autor:
Birthe Roos, Haiwei Gu, Yong Seon Choi, Lauren Abell, Mirjam M.C. Wamelink, Rong Tian, Daniel Raftery, Richard D. Palmiter, Maengjo Kim, Lorena Garcia-Menendez
Publikováno v:
Circulation Research. 119
Mutations in the γ2-subunit of AMPK (encoded by PRKAG2 gene) cause glycogen storage cardiomyopathy. We generated a mouse model with cardiac specific deletion of γ2-AMPK (cKO) to define its function in the heart. The cKO mice were born normal and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae07ac20737e0a4512c316926a2df9
https://doi.org/10.1161/res.119.suppl_1.401
https://doi.org/10.1161/res.119.suppl_1.401