Anti-hemagglutinin monomeric nanobody provides prophylactic immunity against H1 subtype influenza A viruses.

Autor: Elena Susana Barbieri, Carla Sosa-Holt, Lorena Itati Ibañez, Josefina Baztarrica, Lorena Garaicoechea, Claire Lindsey Gay, Carlos Joaquin Caceres, Matias Aduriz, Elsa Baumeister, José Angel Escribano, Daniel Perez, Andrés Wigdorovitz, Gladys Viviana Parreño, Mariana Puntel

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0301664 (2024)

Influenza viruses constitute a major threat to human health globally. The viral surface glycoprotein hemagglutinin (HA) is the immunodominant antigen, contains the site for binding to the cellular receptor (RBS), and it is the major target of neutral

Externí odkaz: https://doaj.org/article/5e6a4d89374341c0a34b3abab3a03132

Llama nanoantibodies with therapeutic potential against human norovirus diarrhea.

Autor: Lorena Garaicoechea, Andrea Aguilar, Gabriel I Parra, Marina Bok, Stanislav V Sosnovtsev, Gabriela Canziani, Kim Y Green, Karin Bok, Viviana Parreño

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133665 (2015)

Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages

Externí odkaz: https://doaj.org/article/d915988b38be4917861c49915441810e

Anti-VP6 VHH: An Experimental Treatment for Rotavirus A-Associated Disease

Autor: S. Miño, Celina G. Vega, Lucia Maffey, Viviana Parreño, Lorena Garaicoechea

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS One 11 (9) : e0162351. (2016)
INTA Digital (INTA)
Instituto Nacional de Tecnología Agropecuaria
instacron:INTA
PLoS ONE, Vol 11, Iss 9, p e0162351 (2016)
PLoS ONE

Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody fragments (VHH) -2KD1 and 3B2- as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79063e08e0c60bbf9ccf623aa87e05c8
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162351

Translational fusion and redirection to thylakoid lumen as strategies to improve the accumulation of a camelid antibody fragment in transplastomic tobacco

Autor: Lorena Garaicoechea, Andrés Wigdorovitz, Viviana Parreño, E. Federico Alfano, Fernando Bravo-Almonacid, Ezequiel Lentz

Publikováno v: Planta. 236:703-714

Fragments from camelid single-chain antibodies known as VHHs or nanobodies represent a valuable tool in diagnostics, investigation and passive immunity therapy. Here, we explored different strategies to improve the accumulation of a neutralizing VHH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac116ef7b77f4e8b788fccddfb116171
https://doi.org/10.1007/s00425-012-1642-x

Milk supplemented with immune colostrum: Protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus

Autor: Celina G. Vega, Gisela Ariana Marcoppido, F. Fernandez, Lorena Garaicoechea, Daniela Rodriguez, Linda J. Saif, Viviana Parreño

Publikováno v: Veterinary Immunology and Immunopathology. 136:12-27

Group A bovine rotavirus (BRV) is the major cause of neonatal calf diarrhea worldwide. As a preventive strategy, we evaluated the protection and immunomodulation in two groups of BRV-inoculated calves. All calves received control colostrum (CC; VN =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e4529761ac6a6f279bfa32ad0f1fa9
https://doi.org/10.1016/j.vetimm.2010.01.003