A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance

Autor: Hyeong-Min Lee, M. Bram Kuijer, Nerea Ruiz Blanes, Ellen P. Clark, Megumi Aita, Lorena Galiano Arjona, Agnieszka Kokot, Noah Sciaky, Jeremy M. Simon, Sanchita Bhatnagar, Benjamin D. Philpot, Andrea Cerase

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-11 (2020)

Abstract Background Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological

Externí odkaz: https://doaj.org/article/f1d6c74a535f4002b4d27d4a54f485ae

Effects of Climate Change on Water Quality in the Jucar River Basin (Spain)

Autor: Miguel A. Pérez-Martín, César Paradinas Blázquez, Emma Gaitán, María Pedro-Monzonís, Toni Rubio, Javier Macián Cervera, Robert Monjo, Sergio Ferriz-Sánchez, Lorena Galiano, Miguel Añó Soto, Gabriel Gómez-Martínez, Pura Almenar Llorens, Darío Redolat, Carlos Prado-López

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
Water, Vol 13, Iss 2424, p 2424 (2021)
Water
Volume 13
Issue 17

[EN] The Mediterranean region is a climate change hotspot, especially concerning issues of hydrological planning and urban water supply systems. In this context, the Jucar River Basin (Spain) presents an increase of frequency, intensity and duration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d84a258c68073b8161c6c1321ed4f31
http://hdl.handle.net/10251/176486

A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance

Autor: Agnieszka Kokot, Noah Sciaky, Jeremy M. Simon, Hyeong-Min Lee, Lorena Galiano Arjona, Nerea Ruiz Blanes, M. Bram Kuijer, Andrea Cerase, Benjamin D. Philpot, Ellen P. Clark, Sanchita Bhatnagar, Megumi Aita

Publikováno v: Journal of Neurodevelopmental Disorders
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-11 (2020)
Journal of neurodevelopmental disorders, vol 12, iss 1

Background Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological defects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1756507511338468812543b6ec88c8da
http://hdl.handle.net/11568/1121003

Additional file 1 of A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance

Autor: Hyeong-Min Lee, M. Bram Kuijer, Blanes, Nerea Ruiz, Clark, Ellen P., Aita, Megumi, Arjona, Lorena Galiano, Kokot, Agnieszka, Sciaky, Noah, Simon, Jeremy M., Sanchita Bhatnagar, Philpot, Benjamin D., Cerase, Andrea

Additional file 1: Supplementary figure 1. Compound validation under different treatment regimens. A) AG490 validation in 6-well plate format. Relative Luminescence Units (RLU) is shown in function of the drug treatment for the clone Xi8. B) qRT-PCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a84c8c80bd061be84b65e28e2999d9

Genetic and phenotypic associations between root architecture, arbuscular mycorrhizal fungi colonisation and low phosphate tolerance instrawberry (Fragaria × ananassa)

Autor: Helen Maria Cockerton, Bo Li, Eleftheria Stavridou, Abigail Johnson, Amanda Karlström, Andrew Douglas Armitage, Ana Martinez-Crucis, Lorena Galiano Arjona, Richard Jonathan Harrison

BackgroundPhosphate is an essential plant macronutrient required to achieve maximum crop yield. Roots are able to uptake soil phosphate from the immediate root area, thus creating a nutrient depletion zone. Many plants are able to exploit phosphate f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6f2674ec77f91b90a38921e0b0a3e23
https://doi.org/10.21203/rs.2.18300/v1