Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Lorena Duca"'
Autor:
Elena Di Pierro, Miriana Perrone, Milena Franco, Francesca Granata, Lorena Duca, Debora Lattuada, Giacomo De Luca, Giovanna Graziadei
Publikováno v:
Life, Vol 13, Iss 9, p 1923 (2023)
No published study has investigated the mitochondrial count in patients suffering from acute intermittent porphyria (AIP). In order to determine whether mitochondrial content can influence the pathogenesis of porphyria, we measured the mitochondrial
Externí odkaz:
https://doaj.org/article/f89a1dc69a294aae908ba38b498646dd
Autor:
Giovanna Graziadei, Lorena Duca, Francesca Granata, Giacomo De Luca, Anna De Giovanni, Valentina Brancaleoni, Isabella Nava, Elena Di Pierro
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Partial deficiency of the last enzyme of the heme biosynthetic pathway, namely, ferrochelatase (FECH), is responsible for erythropoietic protoporphyria (EPP) in humans. This disorder is characterized by painful skin photosensitivity, due to excessive
Externí odkaz:
https://doaj.org/article/4401be791f6f440fb3d3a8b9429ffdfa
Autor:
Lorena Duca, Francesca Granata, Elena Di Pierro, Valentina Brancaleoni, Giovanna Graziadei, Isabella Nava
Publikováno v:
Metabolites, Vol 12, Iss 10, p 919 (2022)
Mutations in the ferroportin (FPN) gene SLC40A1 alter iron recycling and cause disturbances in iron homeostasis. The variants of TMPRSS6 contribute to the development of iron deficiencies. In this study, we determined the role of FPN and TMPRSS6 gene
Externí odkaz:
https://doaj.org/article/630ba60cbe4e47e7b3cc42fd2d622d47
Autor:
Francesca Granata, Lorena Duca, Valentina Brancaleoni, Silvia Fustinoni, Giacomo De Luca, Irene Motta, Giovanna Graziadei, Elena Di Pierro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The homeostasis of tissues in a chronic disease is an essential function of the alternative pathway (AP) of the complement system (CS). However, if not controlled, it may also be detrimental to healthy cells with a consequent aggravation of symptoms.
Externí odkaz:
https://doaj.org/article/a89c4b640de94b6383a1c737fe832afb
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 12, Iss 1 (2020)
b-thalassemia is a hereditary disorder caused by defective production of b-globin chains of hemoglobin (Hb) that leads to an increased a/b globins ratio with subsequent free a-globins. Alpha globin excess causes oxidative stress, RBCs membrane damage
Externí odkaz:
https://doaj.org/article/1ee4fa2a1f674da287972c0ce14444ab
Autor:
Lorena Duca, Sara Ottolenghi, Silvia Coppola, Rocco Rinaldo, Michele Dei Cas, Federico Maria Rubino, Rita Paroni, Michele Samaja, Davide Alberto Chiumello, Irene Motta
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1460 (2021)
In patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear mechanisms negatively interfere with the hematopoietic response to hypoxia. Although sti
Externí odkaz:
https://doaj.org/article/c47790d9e5dc4533b57386d99d42f738
Autor:
Miriam Longo, Erika Paolini, Marica Meroni, Lorena Duca, Irene Motta, Anna Ludovica Fracanzani, Elena Di Pierro, Paola Dongiovanni
Publikováno v:
Diagnostics, Vol 11, Iss 9, p 1628 (2021)
Background: Acute intermittent porphyria (AIP) is caused by the haploinsufficiency of porphobilinogen deaminase (PBGD) enzymatic activity. Acute attacks occur in response to fasting, and alterations in glucose metabolism, insulin resistance, and mito
Externí odkaz:
https://doaj.org/article/c75945978aec472eb28552eb6b78725b
Autor:
Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2017 (2017)
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytoki
Externí odkaz:
https://doaj.org/article/6b050f3683214814aa5b93a6fa992c9a
Publikováno v:
European Journal of Case Reports in Internal Medicine, Vol 1, Iss 1 (2014)
Objectives: Thrombocytopenia and splenomegaly are common features in several haematological disorders. Gaucher disease (GD) is a rare lysosomal storage disorder frequently characterized by thrombocytopenia and splenomegaly, which represents a clinica
Externí odkaz:
https://doaj.org/article/49a9b3d22c874d5289a782372e2ed066
Autor:
Valeria Santini, Domenico Girelli, Alessandro Sanna, Nicola Martinelli, Lorena Duca, Natascia Campostrini, Agostino Cortelezzi, Michela Corbella, Alberto Bosi, Gianluigi Reda, Oliviero Olivieri, Maria Domenica Cappellini
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23109 (2011)
Iron overload may represent an additional clinical problem in patients with Myelodysplastic Syndromes (MDS), with recent data suggesting prognostic implications. Beyond red blood cells transfusions, dysregulation of hepcidin, the key iron hormone, ma
Externí odkaz:
https://doaj.org/article/c475cef064484c0cb2b4948e1ef12d73